Gene description for TULP3
Gene name tubby like protein 3
Gene symbol TULP3
Other names/aliases TUBL3
Species Homo sapiens
 Database cross references - TULP3
ExoCarta ExoCarta_7289
Vesiclepedia VP_7289
Entrez Gene 7289
HGNC 12425
MIM 604730
UniProt O75386  
 TULP3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TULP3
Molecular Function
    G protein-coupled receptor binding GO:0001664 IDA
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 NAS
    enzyme binding GO:0019899 IPI
    phosphatidylinositol binding GO:0035091 IDA
    protein-containing complex binding GO:0044877 IDA
    intraciliary transport particle A binding GO:0120160 IDA
Biological Process
    neural tube closure GO:0001843 IEA
    regulation of DNA-templated transcription GO:0006355 NAS
    G protein-coupled receptor signaling pathway GO:0007186 NAS
    brain development GO:0007420 IEA
    regulation of G protein-coupled receptor signaling pathway GO:0008277 IDA
    regulation of G protein-coupled receptor signaling pathway GO:0008277 IDA
    regulation of G protein-coupled receptor signaling pathway GO:0008277 IMP
    anterior/posterior pattern specification GO:0009952 IEA
    central nervous system neuron differentiation GO:0021953 IEA
    embryonic camera-type eye development GO:0031076 IEA
    embryonic digit morphogenesis GO:0042733 IEA
    negative regulation of smoothened signaling pathway GO:0045879 IDA
    embryonic neurocranium morphogenesis GO:0048702 IEA
    bone development GO:0060348 IEA
    bronchus morphogenesis GO:0060434 IEA
    smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 IEA
    protein localization to cilium GO:0061512 IBA
    protein localization to cilium GO:0061512 IDA
    protein localization to cilium GO:0061512 IGI
    protein localization to cilium GO:0061512 IMP
    ganglion development GO:0061548 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 NAS
    cilium GO:0005929 IBA
    cilium GO:0005929 IDA
    cilium GO:0005929 TAS
    axoneme GO:0005930 IEA
    ciliary base GO:0097546 IDA
    9+0 non-motile cilium GO:0097731 IDA
 Experiment description of studies that identified TULP3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TULP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCRS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ROPN1  
Two-hybrid Homo sapiens
3 FN3KRP 79672
Affinity Capture-MS Homo sapiens
4 ZNF292  
Affinity Capture-MS Homo sapiens
5 PRKAA1 5562
Affinity Capture-MS Homo sapiens
6 TFB1M  
Affinity Capture-MS Homo sapiens
7 ARHGEF2 9181
Affinity Capture-MS Homo sapiens
8 MTHFR 4524
Affinity Capture-MS Homo sapiens
9 SERPINB6 5269
Affinity Capture-MS Homo sapiens
10 OCLN 100506658
Proximity Label-MS Homo sapiens
11 SDHB 6390
Affinity Capture-MS Homo sapiens
12 KPNA1 3836
Affinity Capture-MS Homo sapiens
13 LAMP3  
Proximity Label-MS Homo sapiens
14 LANCL1 10314
Affinity Capture-MS Homo sapiens
15 GJA1 2697
Proximity Label-MS Homo sapiens
16 PPFIA3 8541
Affinity Capture-MS Homo sapiens
17 CTBP2 1488
Affinity Capture-MS Homo sapiens
18 PM20D2 135293
Affinity Capture-MS Homo sapiens
19 COPS6 10980
Affinity Capture-MS Homo sapiens
20 RNF25 64320
Affinity Capture-MS Homo sapiens
21 DHPS 1725
Affinity Capture-MS Homo sapiens
22 IFT122 55764
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 BYSL 705
Affinity Capture-MS Homo sapiens
24 SRGAP2 23380
Affinity Capture-MS Homo sapiens
25 GTPBP1 9567
Affinity Capture-MS Homo sapiens
26 RIOK3 8780
Affinity Capture-MS Homo sapiens
27 PPP6R3 55291
Affinity Capture-MS Homo sapiens
28 PSMD10 5716
Affinity Capture-MS Homo sapiens
29 USP47 55031
Affinity Capture-MS Homo sapiens
30 AKAP8L  
Affinity Capture-MS Homo sapiens
31 RGL1  
Affinity Capture-MS Homo sapiens
32 E2F6 1876
Affinity Capture-MS Homo sapiens
33 KBTBD6  
Affinity Capture-MS Homo sapiens
34 WDR73  
Affinity Capture-MS Homo sapiens
35 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 WDR48 57599
Affinity Capture-MS Homo sapiens
37 STRN4 29888
Affinity Capture-MS Homo sapiens
38 STRN 6801
Affinity Capture-MS Homo sapiens
39 GLG1 2734
Affinity Capture-MS Homo sapiens
40 FTO 79068
Affinity Capture-MS Homo sapiens
41 SARS2 54938
Affinity Capture-MS Homo sapiens
42 RANBP10 57610
Affinity Capture-MS Homo sapiens
43 TBL1XR1 79718
Affinity Capture-MS Homo sapiens
44 CGNL1  
Affinity Capture-MS Homo sapiens
45 NUMBL 9253
Affinity Capture-MS Homo sapiens
46 CXADR 1525
Proximity Label-MS Homo sapiens
47 MRPS23 51649
Affinity Capture-MS Homo sapiens
48 ANP32B 10541
Affinity Capture-MS Homo sapiens
49 COPS5 10987
Affinity Capture-MS Homo sapiens
50 TRIM50  
Affinity Capture-MS Homo sapiens
51 RFC3 5983
Affinity Capture-MS Homo sapiens
52 FLII 2314
Affinity Capture-MS Homo sapiens
53 STT3A 3703
Affinity Capture-MS Homo sapiens
54 GCAT  
Affinity Capture-MS Homo sapiens
55 PIP4K2B 8396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 C11orf52 91894
Proximity Label-MS Homo sapiens
58 IFT81 28981
Affinity Capture-MS Homo sapiens
59 TINAGL1 64129
Affinity Capture-MS Homo sapiens
60 BEND3  
Affinity Capture-MS Homo sapiens
61 PHKA1 5255
Affinity Capture-MS Homo sapiens
62 FAM120B 84498
Affinity Capture-MS Homo sapiens
63 NAA10 8260
Affinity Capture-MS Homo sapiens
64 ANAPC7 51434
Affinity Capture-MS Homo sapiens
65 AASDHPPT 60496
Affinity Capture-MS Homo sapiens
66 STRIP1 85369
Affinity Capture-MS Homo sapiens
67 GTSE1 51512
Affinity Capture-MS Homo sapiens
68 NT5DC2 64943
Affinity Capture-MS Homo sapiens
69 PPP1R15B  
Affinity Capture-MS Homo sapiens
70 RAB35 11021
Proximity Label-MS Homo sapiens
71 PKN2 5586
Affinity Capture-MS Homo sapiens
72 ARIH2 10425
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 GPS1 2873
Affinity Capture-MS Homo sapiens
74 USP7 7874
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CSNK2B 1460
Affinity Capture-MS Homo sapiens
76 MEF2C  
Affinity Capture-MS Homo sapiens
77 IFT140 9742
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 SH3GL1 6455
Affinity Capture-MS Homo sapiens
79 EXOC3 11336
Affinity Capture-MS Homo sapiens
80 ADSL 158
Affinity Capture-MS Homo sapiens
81 GTF2I 2969
Affinity Capture-MS Homo sapiens
82 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 HEXIM1 10614
Affinity Capture-MS Homo sapiens
84 MRPS25 64432
Affinity Capture-MS Homo sapiens
85 JMJD6 23210
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 LOXL2 4017
Affinity Capture-MS Homo sapiens
88 MAPK3 5595
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 GGPS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 CDC23 8697
Affinity Capture-MS Homo sapiens
91 USP11 8237
Affinity Capture-MS Homo sapiens
92 MEPCE 56257
Affinity Capture-MS Homo sapiens
93 CDK5 1020
Affinity Capture-MS Homo sapiens
94 EEF2K  
Affinity Capture-MS Homo sapiens
95 TUB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 TLK2  
Affinity Capture-MS Homo sapiens
97 AGK 55750
Affinity Capture-MS Homo sapiens
98 KRTAP10-1  
Two-hybrid Homo sapiens
99 LYN 4067
Proximity Label-MS Homo sapiens
100 PRKAG1 5571
Affinity Capture-MS Homo sapiens
101 MCAM 4162
Proximity Label-MS Homo sapiens
102 CBL 867
Affinity Capture-MS Homo sapiens
103 TCEA1 6917
Affinity Capture-MS Homo sapiens
104 SNX33 257364
Affinity Capture-MS Homo sapiens
105 UBR5 51366
Affinity Capture-MS Homo sapiens
106 MKRN2 23609
Affinity Capture-RNA Homo sapiens
107 ANKHD1 54882
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 AMPD2 271
Affinity Capture-MS Homo sapiens
109 NUMB 8650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 TTC21B 79809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 LRCH1 23143
Affinity Capture-MS Homo sapiens
112 TTN 7273
Affinity Capture-MS Homo sapiens
113 MRPS5 64969
Affinity Capture-MS Homo sapiens
114 FOXK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 DCAF7 10238
Affinity Capture-MS Homo sapiens
116 RAD18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 GTF3C2  
Affinity Capture-MS Homo sapiens
118 DICER1  
Affinity Capture-MS Homo sapiens
119 ASCC2 84164
Affinity Capture-MS Homo sapiens
120 IFT74 80173
Affinity Capture-MS Homo sapiens
121 CSNK1E 1454
Affinity Capture-MS Homo sapiens
122 PML 5371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 GPC6 10082
Affinity Capture-MS Homo sapiens
124 LRRFIP1 9208
Affinity Capture-MS Homo sapiens
125 RAB11FIP5 26056
Affinity Capture-MS Homo sapiens
126 COPS7B 64708
Affinity Capture-MS Homo sapiens
127 TMEM33 55161
Affinity Capture-MS Homo sapiens
128 CTDSPL 10217
Proximity Label-MS Homo sapiens
129 PRKAR1A 5573
Affinity Capture-MS Homo sapiens
130 ZBED1  
Affinity Capture-MS Homo sapiens
131 ACBD3 64746
Affinity Capture-MS Homo sapiens
132 KRTAP10-7  
Two-hybrid Homo sapiens
133 NDEL1 81565
Affinity Capture-MS Homo sapiens
134 RING1 6015
Affinity Capture-MS Homo sapiens
135 BIRC2  
Affinity Capture-MS Homo sapiens
136 TONSL  
Affinity Capture-MS Homo sapiens
137 TRIP4 9325
Affinity Capture-MS Homo sapiens
138 DIP2B 57609
Affinity Capture-MS Homo sapiens
139 COPS2 9318
Affinity Capture-MS Homo sapiens
140 HBS1L 10767
Affinity Capture-MS Homo sapiens
141 CDK9 1025
Affinity Capture-MS Homo sapiens
142 AHCYL1 10768
Affinity Capture-MS Homo sapiens
143 MRPS35 60488
Affinity Capture-MS Homo sapiens
144 TXNDC5 81567
Affinity Capture-MS Homo sapiens
145 RALB 5899
Affinity Capture-MS Homo sapiens
146 UBXN7 26043
Affinity Capture-MS Homo sapiens
147 POLD3  
Affinity Capture-MS Homo sapiens
148 LAMP1 3916
Proximity Label-MS Homo sapiens
149 GPC3 2719
Affinity Capture-MS Homo sapiens
150 TTC4  
Affinity Capture-MS Homo sapiens
151 CUL3 8452
Affinity Capture-MS Homo sapiens
152 ASAP3 55616
Affinity Capture-MS Homo sapiens
153 NAF1  
Affinity Capture-MS Homo sapiens
154 CTTN 2017
Affinity Capture-MS Homo sapiens
155 HDHD2 84064
Affinity Capture-MS Homo sapiens
156 NHSL1  
Affinity Capture-MS Homo sapiens
157 RNF138  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 ARF6 382
Proximity Label-MS Homo sapiens
159 KANSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 PPP6R2 9701
Affinity Capture-MS Homo sapiens
161 DCAF16 54876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 EIF2B3 8891
Affinity Capture-MS Homo sapiens
163 EIF2S2 8894
Affinity Capture-MS Homo sapiens
164 KBTBD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 UBE2R2 54926
Affinity Capture-MS Homo sapiens
166 WAPAL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
167 SENP7  
Affinity Capture-MS Homo sapiens
168 BLK 640
Affinity Capture-MS Homo sapiens
169 TELO2 9894
Affinity Capture-MS Homo sapiens
170 PSTPIP1 9051
Two-hybrid Homo sapiens
171 BIRC6 57448
Affinity Capture-MS Homo sapiens
172 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
173 ANKRD52 283373
Affinity Capture-MS Homo sapiens
174 SLAIN2  
Affinity Capture-MS Homo sapiens
175 AKT1S1 84335
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 LYSMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 AP3M2  
Affinity Capture-MS Homo sapiens
178 PHKB 5257
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 PHF6  
Affinity Capture-MS Homo sapiens
180 DIS3 22894
Affinity Capture-MS Homo sapiens
181 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
182 AP2A2 161
Affinity Capture-MS Homo sapiens
183 RAD54L2  
Affinity Capture-MS Homo sapiens
184 SORBS3 10174
Affinity Capture-MS Homo sapiens
185 NOB1  
Affinity Capture-MS Homo sapiens
186 MAGEA6  
Two-hybrid Homo sapiens
187 RHOB 388
Proximity Label-MS Homo sapiens
188 SBF1 6305
Affinity Capture-MS Homo sapiens
189 LRCH2  
Affinity Capture-MS Homo sapiens
190 MRPS17 51373
Affinity Capture-MS Homo sapiens
191 HAT1 8520
Affinity Capture-MS Homo sapiens
192 RBM4 5936
Affinity Capture-MS Homo sapiens
193 COPS3 8533
Affinity Capture-MS Homo sapiens
194 PPFIA1 8500
Affinity Capture-MS Homo sapiens
195 FOXK1 221937
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 DOCK6 57572
Affinity Capture-MS Homo sapiens
197 HSPG2 3339
Affinity Capture-MS Homo sapiens
198 DPH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 KRTAP10-5  
Two-hybrid Homo sapiens
200 DCTPP1 79077
Affinity Capture-MS Homo sapiens
201 TCF25 22980
Affinity Capture-MS Homo sapiens
202 BACH2 60468
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 RAB3GAP2 25782
Affinity Capture-MS Homo sapiens
204 GPRASP2  
Affinity Capture-MS Homo sapiens
205 ALG13 79868
Affinity Capture-MS Homo sapiens
206 ARRB2 409
Affinity Capture-MS Homo sapiens
207 ZNF24  
Affinity Capture-MS Homo sapiens
208 MRPS7 51081
Affinity Capture-MS Homo sapiens
209 ZSCAN23  
Affinity Capture-MS Homo sapiens
210 SMN1 6606
Affinity Capture-MS Homo sapiens
211 TULP1  
Affinity Capture-MS Homo sapiens
212 GRB2 2885
Affinity Capture-MS Homo sapiens
213 MAST3  
Affinity Capture-MS Homo sapiens
214 TARS2 80222
Affinity Capture-MS Homo sapiens
215 PDK3 5165
Affinity Capture-MS Homo sapiens
216 MAX  
Affinity Capture-MS Homo sapiens
217