Gene description for TTC21B
Gene name tetratricopeptide repeat domain 21B
Gene symbol TTC21B
Other names/aliases ATD4
IFT139
JBTS11
NPHP12
Nbla10696
SRTD4
THM1
Species Homo sapiens
 Database cross references - TTC21B
ExoCarta ExoCarta_79809
Entrez Gene 79809
HGNC 25660
MIM 612014
UniProt Q7Z4L5  
 TTC21B identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TTC21B
Biological Process
    smoothened signaling pathway GO:0007224 IEA
    ventricular system development GO:0021591 IEA
    cilium morphogenesis GO:0060271 IBA
    intraciliary transport involved in cilium morphogenesis GO:0035735 IEA
    regulation of smoothened signaling pathway GO:0008589 IEA
    intraciliary retrograde transport GO:0035721 IBA
    forebrain dorsal/ventral pattern formation GO:0021798 IEA
    protein localization to cilium GO:0061512 IMP
    regulation of transcription from RNA polymerase II promoter GO:0006357 IMP
    organelle organization GO:0006996 TAS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    intraciliary transport particle A GO:0030991 IDA
    ciliary tip GO:0097542 TAS
    primary cilium GO:0072372 TAS
    nuclear chromatin GO:0000790 IEA
    cytoskeleton GO:0005856 IEA
    cilium GO:0005929 IBA
 Experiment description of studies that identified TTC21B in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TTC21B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TTC21B is involved
PathwayEvidenceSource
Hedgehog 'off' state TAS Reactome
Intraflagellar transport TAS Reactome





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