Gene description for IFT122
Gene name intraflagellar transport 122
Gene symbol IFT122
Other names/aliases CED
CED1
SPG
WDR10
WDR10p
WDR140
Species Homo sapiens
 Database cross references - IFT122
ExoCarta ExoCarta_55764
Entrez Gene 55764
HGNC 13556
MIM 606045
UniProt Q9HBG6  
 IFT122 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for IFT122
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    camera-type eye morphogenesis GO:0048593 ISS
    establishment of protein localization to organelle GO:0072594 IEA
    organelle organization GO:0006996 TAS
    neural tube closure GO:0001843 ISS
    embryonic forelimb morphogenesis GO:0035115 IEA
    limb development GO:0060173 ISS
    cilium morphogenesis GO:0060271 ISS
    intraciliary anterograde transport GO:0035720 IEA
    cilium assembly GO:0042384 IBA
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    ciliary receptor clustering involved in smoothened signaling pathway GO:0060830 IEA
    embryonic body morphogenesis GO:0010172 ISS
    embryonic digit morphogenesis GO:0042733 IEA
    embryonic heart tube left/right pattern formation GO:0060971 IEA
    signal transduction downstream of smoothened GO:0007227 IEA
    embryonic heart tube development GO:0035050 ISS
    protein localization to cilium GO:0061512 IMP
    negative regulation of smoothened signaling pathway GO:0045879 ISS
    negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning GO:0021914 IEA
    intraciliary retrograde transport GO:0035721 ISS
    smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 IEA
Subcellular Localization
    ciliary tip GO:0097542 TAS
    intraciliary transport particle A GO:0030991 IDA
    cilium GO:0005929 IBA
    membrane GO:0016020 IDA
    primary cilium GO:0072372 TAS
    photoreceptor connecting cilium GO:0032391 ISS
    cytoplasm GO:0005737 IEA
    ciliary basal body GO:0036064 IEA
 Experiment description of studies that identified IFT122 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IFT122
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IFT122 is involved
PathwayEvidenceSource
Hedgehog 'off' state TAS Reactome
Intraflagellar transport TAS Reactome





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