Gene description for RNF157
Gene name ring finger protein 157
Gene symbol RNF157
Other names/aliases -
Species Homo sapiens
 Database cross references - RNF157
ExoCarta ExoCarta_114804
Vesiclepedia VP_114804
Entrez Gene 114804
HGNC 29402
UniProt Q96PX1  
 RNF157 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for RNF157
Molecular Function
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 ISS
Biological Process
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 ISS
    negative regulation of apoptotic process GO:0043066 ISS
    positive regulation of dendrite extension GO:1903861 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    cell body GO:0044297 ISS
 Experiment description of studies that identified RNF157 in exosomes
1
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RNF157
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SERBP1 26135
Affinity Capture-MS Homo sapiens
2 UBE2G2  
Two-hybrid Homo sapiens
3 ATRN 8455
Affinity Capture-MS Homo sapiens
4 IFT122 55764
Affinity Capture-MS Homo sapiens
5 CUL3 8452
Affinity Capture-MS Homo sapiens
6 ANKRD46 157567
Affinity Capture-MS Homo sapiens
7 ATRNL1 26033
Affinity Capture-MS Homo sapiens
8 MIOS 54468
Affinity Capture-MS Homo sapiens
9 FBXO2 26232
Affinity Capture-MS Homo sapiens
10 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
11 CBWD3  
Affinity Capture-MS Homo sapiens
12 APPBP2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RNF157 is involved
No pathways found





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