Gene description for LOXL4
Gene name lysyl oxidase-like 4
Gene symbol LOXL4
Other names/aliases LOXC
Species Homo sapiens
 Database cross references - LOXL4
ExoCarta ExoCarta_84171
Vesiclepedia VP_84171
Entrez Gene 84171
HGNC 17171
MIM 607318
UniProt Q96JB6  
 LOXL4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Saliva 19199708    
 Gene ontology annotations for LOXL4
Molecular Function
    protein-lysine 6-oxidase activity GO:0004720 IBA
    protein-lysine 6-oxidase activity GO:0004720 IDA
    copper ion binding GO:0005507 IEA
    protein binding GO:0005515 IPI
Biological Process
    collagen fibril organization GO:0030199 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    membrane GO:0016020 IEA
    receptor complex GO:0043235 IDA
    collagen-containing extracellular matrix GO:0062023 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified LOXL4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for LOXL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UTP18  
Affinity Capture-MS Homo sapiens
2 BPIFA1 51297
Affinity Capture-MS Homo sapiens
3 WDR6 11180
Affinity Capture-MS Homo sapiens
4 CCT3 7203
Affinity Capture-MS Homo sapiens
5 GTF3C5 9328
Affinity Capture-MS Homo sapiens
6 TUBB8 347688
Affinity Capture-MS Homo sapiens
7 IFT122 55764
Affinity Capture-MS Homo sapiens
8 PRMT6  
Two-hybrid Homo sapiens
9 TRIM33 51592
Affinity Capture-MS Homo sapiens
10 PUM2 23369
Affinity Capture-MS Homo sapiens
11 CCT4 10575
Affinity Capture-MS Homo sapiens
12 CCT6B 10693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 THSD4 79875
Affinity Capture-MS Homo sapiens
14 NEDD1 121441
Affinity Capture-MS Homo sapiens
15 HDAC3 8841
Affinity Capture-MS Homo sapiens
16 DDA1  
Affinity Capture-MS Homo sapiens
17 B3GNT2 10678
Affinity Capture-MS Homo sapiens
18 HSPA2 3306
Affinity Capture-MS Homo sapiens
19 HELZ 9931
Affinity Capture-MS Homo sapiens
20 SUV39H1  
Two-hybrid Homo sapiens
21 RECQL4  
Affinity Capture-MS Homo sapiens
22 OBSL1 23363
Affinity Capture-MS Homo sapiens
23 TUBGCP6 85378
Affinity Capture-MS Homo sapiens
24 TUBB 203068
Affinity Capture-MS Homo sapiens
25 VWA5B2  
Affinity Capture-MS Homo sapiens
26 RAD23A 5886
Two-hybrid Homo sapiens
27 HSPA8 3312
Affinity Capture-MS Homo sapiens
28 ATXN2 6311
Affinity Capture-MS Homo sapiens
29 CCT2 10576
Affinity Capture-MS Homo sapiens
30 BAG5 9529
Affinity Capture-MS Homo sapiens
31 POM121C  
Affinity Capture-MS Homo sapiens
32 TCP1 6950
Affinity Capture-MS Homo sapiens
33 RNF32  
Two-hybrid Homo sapiens
34 CEP192 55125
Affinity Capture-MS Homo sapiens
35 BRE 9577
Affinity Capture-MS Homo sapiens
36 CCT5 22948
Affinity Capture-MS Homo sapiens
37 TUBA1B 10376
Affinity Capture-MS Homo sapiens
38 EXPH5  
Affinity Capture-MS Homo sapiens
39 EXOC6 54536
Two-hybrid Homo sapiens
40 HPS3 84343
Affinity Capture-MS Homo sapiens
41 TRIM32 22954
Affinity Capture-MS Homo sapiens
42 TUBA1C 84790
Affinity Capture-MS Homo sapiens
43 STIL  
Affinity Capture-MS Homo sapiens
44 TAF6L 10629
Affinity Capture-MS Homo sapiens
45 ZNF609  
Affinity Capture-MS Homo sapiens
46 BAG3 9531
Affinity Capture-MS Homo sapiens
47 TRIP13 9319
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
48 ARHGAP32  
Affinity Capture-MS Homo sapiens
49 RNF219  
Affinity Capture-MS Homo sapiens
50 MAP7 9053
Affinity Capture-MS Homo sapiens
51 DCAF10  
Affinity Capture-MS Homo sapiens
52 APOE 348
Two-hybrid Homo sapiens
53 IGHA1 3493
Affinity Capture-MS Homo sapiens
54 CCT6A 908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PRG2  
Affinity Capture-MS Homo sapiens
56 RICTOR 253260
Affinity Capture-MS Homo sapiens
57 DNAJB9 4189
Affinity Capture-MS Homo sapiens
58 CUL9  
Affinity Capture-MS Homo sapiens
59 TUBA4A 7277
Affinity Capture-MS Homo sapiens
60 HAUS5 23354
Affinity Capture-MS Homo sapiens
61 DCAF6 55827
Affinity Capture-MS Homo sapiens
62 MTUS1  
Affinity Capture-MS Homo sapiens
63 TANGO6 79613
Affinity Capture-MS Homo sapiens
64 ARHGEF5  
Affinity Capture-MS Homo sapiens
65 SAV1  
Affinity Capture-MS Homo sapiens
66 AP1M2 10053
Two-hybrid Homo sapiens
67 PIGR 5284
Affinity Capture-MS Homo sapiens
68 STUB1 10273
Affinity Capture-MS Homo sapiens
69 FAM175B 23172
Affinity Capture-MS Homo sapiens
70 RPAP1  
Affinity Capture-MS Homo sapiens
71 ANKHD1-EIF4EBP3  
Affinity Capture-MS Homo sapiens
72 USP34 9736
Affinity Capture-MS Homo sapiens
73 LONP1 9361
Two-hybrid Homo sapiens
74 RNF31 55072
Affinity Capture-MS Homo sapiens
75 CDC37 11140
Two-hybrid Homo sapiens
76 RPTOR 57521
Affinity Capture-MS Homo sapiens
77 SEPHS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 FAM83H 286077
Affinity Capture-MS Homo sapiens
79 DDX58 23586
Affinity Capture-RNA Homo sapiens
80 CCT7 10574
Affinity Capture-MS Homo sapiens
81 SELO 83642
Affinity Capture-MS Homo sapiens
82 PRAME  
Affinity Capture-MS Homo sapiens
83 ZNF195  
Affinity Capture-MS Homo sapiens
84 KDM1A 23028
Two-hybrid Homo sapiens
85 CAD 790
Affinity Capture-MS Homo sapiens
86 DNAJB4 11080
Affinity Capture-MS Homo sapiens
87 ZG16B 124220
Affinity Capture-MS Homo sapiens
88 PUM1 9698
Affinity Capture-MS Homo sapiens
89 WDR59 79726
Affinity Capture-MS Homo sapiens
90 MIB2 142678
Affinity Capture-MS Homo sapiens
91 MAST1  
Two-hybrid Homo sapiens
92 HSPA1B 3304
Affinity Capture-MS Homo sapiens
93 ECSIT 51295
Two-hybrid Homo sapiens
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