Gene description for BPIFA1
Gene name BPI fold containing family A, member 1
Gene symbol BPIFA1
Other names/aliases LUNX
NASG
PLUNC
SPLUNC1
SPURT
bA49G10.5
Species Homo sapiens
 Database cross references - BPIFA1
ExoCarta ExoCarta_51297
Vesiclepedia VP_51297
Entrez Gene 51297
HGNC 15749
MIM 607412
UniProt Q9NP55  
 BPIFA1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for BPIFA1
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
Biological Process
    immune response in nasopharyngeal-associated lymphoid tissue GO:0002395 IBA
    immune response in nasopharyngeal-associated lymphoid tissue GO:0002395 IEP
    antibacterial humoral response GO:0019731 IBA
    antibacterial humoral response GO:0019731 IDA
    surfactant homeostasis GO:0043129 IBA
    surfactant homeostasis GO:0043129 IDA
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IDA
    innate immune response GO:0045087 NAS
    multicellular organismal-level water homeostasis GO:0050891 IDA
    defense response to virus GO:0051607 IEP
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IEP
    negative regulation of single-species biofilm formation in or on host organism GO:1900229 IBA
    negative regulation of single-species biofilm formation in or on host organism GO:1900229 IMP
    regulation of sodium ion transmembrane transport GO:1902305 IDA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified BPIFA1 in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for BPIFA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SAMD11  
Two-hybrid Homo sapiens
2 PRR35  
Two-hybrid Homo sapiens
3 EML2 24139
Two-hybrid Homo sapiens
4 AES 166
Two-hybrid Homo sapiens
5 MKRN3  
Two-hybrid Homo sapiens
6 GFAP 2670
Affinity Capture-MS Homo sapiens
7 BPIFB3  
Affinity Capture-MS Homo sapiens
8 TCF7L2  
Two-hybrid Homo sapiens
9 NTNG1  
Affinity Capture-MS Homo sapiens
10 UBC 7316
Affinity Capture-MS Homo sapiens
11 EBF2  
Affinity Capture-MS Homo sapiens
12 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
13 LOXL4 84171
Affinity Capture-MS Homo sapiens
14 FNDC5  
Affinity Capture-MS Homo sapiens
15 RTP5  
Two-hybrid Homo sapiens
16 HSFY1  
Two-hybrid Homo sapiens
17 USB1  
Affinity Capture-MS Homo sapiens
18 HOXB9  
Two-hybrid Homo sapiens
19 INIP  
Two-hybrid Homo sapiens
20 WNT8B 7479
Affinity Capture-MS Homo sapiens
21 COL8A1 1295
Two-hybrid Homo sapiens
22 DUSP21  
Two-hybrid Homo sapiens
23 SIRPB1 10326
Two-hybrid Homo sapiens
24 OR13C3  
Affinity Capture-MS Homo sapiens
25 UBQLN1 29979
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 SFXN4  
Affinity Capture-MS Homo sapiens
27 Ikbip  
Affinity Capture-MS Mus musculus
28 TIAL1 7073
Two-hybrid Homo sapiens
29 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 UBQLN4 56893
Two-hybrid Homo sapiens
31 ICE2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GCA 25801
Two-hybrid Homo sapiens
33 PMEPA1 56937
Affinity Capture-MS Homo sapiens
34 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 FAM222B  
Two-hybrid Homo sapiens
36 GNG8  
Affinity Capture-MS Homo sapiens
37 C1orf86  
Two-hybrid Homo sapiens
38 ERO1L 30001
Affinity Capture-MS Homo sapiens
39 PCK2 5106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 TLX3  
Two-hybrid Homo sapiens
41 HCK 3055
Two-hybrid Homo sapiens
42 SPNS3  
Affinity Capture-MS Homo sapiens
43 SNRNP25  
Two-hybrid Homo sapiens
44 PPIH 10465
Two-hybrid Homo sapiens
45 ITLN2  
Affinity Capture-MS Homo sapiens
46 HSFY2  
Two-hybrid Homo sapiens
47 CLSTN2 64084
Affinity Capture-MS Homo sapiens
48 TCHH  
Affinity Capture-MS Homo sapiens
49 HLA-DPA1  
Affinity Capture-MS Homo sapiens
50 KRT3 3850
Two-hybrid Homo sapiens
51 ELK3  
Two-hybrid Homo sapiens
52 MTIF3  
Two-hybrid Homo sapiens
53 TMEM176B 28959
Affinity Capture-MS Homo sapiens
54 UBQLN2 29978
Two-hybrid Homo sapiens
55 GADD45GIP1  
Two-hybrid Homo sapiens
56 NPAS2  
Two-hybrid Homo sapiens
57 TFG 10342
Two-hybrid Homo sapiens
58 TMEM237 65062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 ALKBH4  
Two-hybrid Homo sapiens
60 RIBC1  
Affinity Capture-MS Homo sapiens
61 HBM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 C5orf28  
Affinity Capture-MS Homo sapiens
63 KIR2DL4  
Two-hybrid Homo sapiens
64 TWF1 5756
Affinity Capture-MS Homo sapiens
65 SMAD6  
Affinity Capture-MS Homo sapiens
66 ENTHD2  
Two-hybrid Homo sapiens
67 FAM103A1  
Two-hybrid Homo sapiens
68 VPS25 84313
Two-hybrid Homo sapiens
69 ZNF765  
Two-hybrid Homo sapiens
70 PEF1 553115
Two-hybrid Homo sapiens
71 NUP54 53371
Two-hybrid Homo sapiens
72 ZNF695  
Affinity Capture-MS Homo sapiens
73 MKNK1  
Affinity Capture-MS Homo sapiens
74 INCA1  
Two-hybrid Homo sapiens
75 NHLRC2 374354
Affinity Capture-MS Homo sapiens
76 MEIS2  
Two-hybrid Homo sapiens
77 RASL11B  
Affinity Capture-MS Homo sapiens
78 METTL12  
Two-hybrid Homo sapiens
79 TMEM257  
Affinity Capture-MS Homo sapiens
80 KLK10 5655
Affinity Capture-MS Homo sapiens
81 SREK1IP1  
Affinity Capture-MS Homo sapiens
82 RUSC1  
Two-hybrid Homo sapiens
83 CRYBA2  
Two-hybrid Homo sapiens
84 ORAI1 84876
Affinity Capture-Western Homo sapiens
85 FOXN3 1112
Affinity Capture-MS Homo sapiens
86 HNF1B  
Two-hybrid Homo sapiens
87 HS1BP3 64342
Affinity Capture-MS Homo sapiens
88 LNX1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BPIFA1 is involved
PathwayEvidenceSource
Antimicrobial peptides TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome





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