Gene description for FOXN3
Gene name forkhead box N3
Gene symbol FOXN3
Other names/aliases C14orf116
CHES1
PRO1635
Species Homo sapiens
 Database cross references - FOXN3
ExoCarta ExoCarta_1112
Vesiclepedia VP_1112
Entrez Gene 1112
HGNC 1928
MIM 602628
UniProt O00409  
 FOXN3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for FOXN3
Molecular Function
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    cis-regulatory region sequence-specific DNA binding GO:0000987 IBA
    DNA-binding transcription factor activity GO:0003700 IBA
    protein binding GO:0005515 IPI
Biological Process
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    mitotic G2 DNA damage checkpoint signaling GO:0007095 IGI
    negative regulation of DNA-templated transcription GO:0045892 IDA
    craniofacial suture morphogenesis GO:0097094 IEA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IC
 Experiment description of studies that identified FOXN3 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FOXN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCNO  
Affinity Capture-MS Homo sapiens
2 ZBTB34 403341
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LRRC15 131578
Affinity Capture-MS Homo sapiens
4 BPIFA1 51297
Affinity Capture-MS Homo sapiens
5 BTRC 8945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 FAM26D  
Affinity Capture-MS Homo sapiens
8 LYZ 4069
Affinity Capture-MS Homo sapiens
9 IGLC6 3542
Affinity Capture-MS Homo sapiens
10 CALML3 810
Affinity Capture-MS Homo sapiens
11 HEPHL1  
Affinity Capture-MS Homo sapiens
12 IGHA1 3493
Affinity Capture-MS Homo sapiens
13 SRPK2 6733
Biochemical Activity Homo sapiens
14 ALOX15B  
Affinity Capture-MS Homo sapiens
15 IGLL5 100423062
Affinity Capture-MS Homo sapiens
16 CRYAB 1410
Affinity Capture-MS Homo sapiens
17 JCHAIN 3512
Affinity Capture-MS Homo sapiens
18 HRNR 388697
Affinity Capture-MS Homo sapiens
19 MEN1 4221
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
20 FABP4 2167
Affinity Capture-MS Homo sapiens
21 VSIG8  
Affinity Capture-MS Homo sapiens
22 DDB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PMEL 6490
Affinity Capture-MS Homo sapiens
24 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
25 RFX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 KBTBD7  
Affinity Capture-MS Homo sapiens
27 ARL8B 55207
Affinity Capture-MS Homo sapiens
28 FOXO3B 2310
Affinity Capture-MS Homo sapiens
29 HP 3240
Affinity Capture-MS Homo sapiens
30 RFX3 5991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SELENBP1 8991
Affinity Capture-MS Homo sapiens
32 ZG16B 124220
Affinity Capture-MS Homo sapiens
33 DSG4 147409
Affinity Capture-MS Homo sapiens
34 BPIFB1 92747
Affinity Capture-MS Homo sapiens
35 IGKC 3514
Affinity Capture-MS Homo sapiens
36 DUSP14 11072
Affinity Capture-MS Homo sapiens
37 PIGR 5284
Affinity Capture-MS Homo sapiens
38 ACPP 55
Affinity Capture-MS Homo sapiens
39 LCN1 3933
Affinity Capture-MS Homo sapiens
40 FOXR2  
Affinity Capture-MS Homo sapiens
41 LCN2 3934
Affinity Capture-MS Homo sapiens
42 ALB 213
Affinity Capture-MS Homo sapiens
43 LTF 4057
Affinity Capture-MS Homo sapiens
44 TRIM29 23650
Affinity Capture-MS Homo sapiens
45 CHSY1 22856
Affinity Capture-MS Homo sapiens
46 CHSY3 337876
Affinity Capture-MS Homo sapiens
47 SERPINB13 5275
Affinity Capture-MS Homo sapiens
48 RFX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 EXOSC8  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FOXN3 is involved
No pathways found





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