Gene description for BPIFB1
Gene name BPI fold containing family B, member 1
Gene symbol BPIFB1
Other names/aliases C20orf114
LPLUNC1
Species Homo sapiens
 Database cross references - BPIFB1
ExoCarta ExoCarta_92747
Vesiclepedia VP_92747
Entrez Gene 92747
HGNC 16108
UniProt Q8TDL5  
 BPIFB1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for BPIFB1
Molecular Function
    lipid binding GO:0008289 IEA
Biological Process
    innate immune response in mucosa GO:0002227 IBA
    innate immune response in mucosa GO:0002227 IDA
    negative regulation of toll-like receptor 4 signaling pathway GO:0034144 IBA
    negative regulation of toll-like receptor 4 signaling pathway GO:0034144 IDA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified BPIFB1 in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
6
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for BPIFB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ikbip  
Affinity Capture-MS Mus musculus
2 FCN1 2219
Affinity Capture-MS Homo sapiens
3 KLK10 5655
Affinity Capture-MS Homo sapiens
4 GNG8  
Affinity Capture-MS Homo sapiens
5 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TIMM50 92609
Affinity Capture-MS Homo sapiens
7 MLLT1 4298
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TWF1 5756
Affinity Capture-MS Homo sapiens
9 GSK3B 2932
Affinity Capture-MS Homo sapiens
10 TMEM176B 28959
Affinity Capture-MS Homo sapiens
11 TRIM41 90933
Affinity Capture-MS Homo sapiens
12 USP36  
Affinity Capture-MS Homo sapiens
13 MAGEB4  
Affinity Capture-MS Homo sapiens
14 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ARHGAP12  
Affinity Capture-MS Homo sapiens
16 MTMR14 64419
Affinity Capture-MS Homo sapiens
17 ERO1L 30001
Affinity Capture-MS Homo sapiens
18 PCK2 5106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 NHLRC2 374354
Affinity Capture-MS Homo sapiens
20 EBF2  
Affinity Capture-MS Homo sapiens
21 NOX4  
Affinity Capture-MS Homo sapiens
22 RASL11B  
Affinity Capture-MS Homo sapiens
23 SPNS3  
Affinity Capture-MS Homo sapiens
24 SNF8 11267
Affinity Capture-MS Homo sapiens
25 CLCN2  
Affinity Capture-MS Homo sapiens
26 FNDC5  
Affinity Capture-MS Homo sapiens
27 USB1  
Affinity Capture-MS Homo sapiens
28 PPCS 79717
Affinity Capture-MS Homo sapiens
29 ZCCHC17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CDKAL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 TMEM257  
Affinity Capture-MS Homo sapiens
32 TMEM237 65062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PMEPA1 56937
Affinity Capture-MS Homo sapiens
34 PTPN21 11099
Affinity Capture-MS Homo sapiens
35 ZMYND8 23613
Affinity Capture-MS Homo sapiens
36 ITLN2  
Affinity Capture-MS Homo sapiens
37 RIBC1  
Affinity Capture-MS Homo sapiens
38 HBM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 FOXN3 1112
Affinity Capture-MS Homo sapiens
40 LRRC8E 80131
Affinity Capture-MS Homo sapiens
41 EGFL8  
Affinity Capture-MS Homo sapiens
42 MLLT3 4300
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 OR13C3  
Affinity Capture-MS Homo sapiens
44 SFXN4  
Affinity Capture-MS Homo sapiens
45 CYP3A43  
Affinity Capture-MS Homo sapiens
46 GJB5  
Affinity Capture-MS Homo sapiens
47 PTPN14 5784
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BPIFB1 is involved
PathwayEvidenceSource
Antimicrobial peptides TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome





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