Gene description for TMEM176B
Gene name transmembrane protein 176B
Gene symbol TMEM176B
Other names/aliases LR8
Species Homo sapiens
 Database cross references - TMEM176B
ExoCarta ExoCarta_28959
Vesiclepedia VP_28959
Entrez Gene 28959
HGNC 29596
MIM 610385
UniProt Q3YBM2  
 TMEM176B identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for TMEM176B
Biological Process
    organ morphogenesis GO:0009887 TAS
    negative regulation of dendritic cell differentiation GO:2001199 IEA
    cell differentiation GO:0030154 IEA
Subcellular Localization
    nuclear membrane GO:0031965 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified TMEM176B in exosomes
1
Experiment ID 1203
MISEV standards
EM
EV Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for TMEM176B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TMEM176B is involved
No pathways found





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