Gene description for IGLC2
Gene name immunoglobulin lambda constant 2 (Kern-Oz- marker)
Gene symbol IGLC2
Other names/aliases IGLC
Species Homo sapiens
 Database cross references - IGLC2
ExoCarta ExoCarta_3538
Vesiclepedia VP_3538
Entrez Gene 3538
HGNC 5856
 IGLC2 identified in exosomes derived from the following tissue/cell type
Breast milk 17641064    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells Unpublished / Not applicable
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for IGLC2
Molecular Function
    antigen binding GO:0003823 IBA
Biological Process
    immunoglobulin mediated immune response GO:0016064 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 HDA
    IgG immunoglobulin complex GO:0071735 IBA
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified IGLC2 in exosomes
1
Experiment ID 46
MISEV standards
EM|IEM
Biophysical techniques
HSC70|CD63|MHCII|CD81|CD86
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Colostrum
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
2
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
5
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IGLC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CIR1  
Affinity Capture-MS Homo sapiens
2 SNX27 81609
Affinity Capture-MS Homo sapiens
3 RHBDD1 84236
Affinity Capture-MS Homo sapiens
4 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
5 FANCD2  
Affinity Capture-MS Homo sapiens
6 AGPAT1 10554
Affinity Capture-MS Homo sapiens
7 SCGB1D1  
Affinity Capture-MS Homo sapiens
8 IGLL5 100423062
Affinity Capture-MS Homo sapiens
9 TMEM176B 28959
Affinity Capture-MS Homo sapiens
10 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 GNG8  
Affinity Capture-MS Homo sapiens
12 TIMM10  
Affinity Capture-MS Homo sapiens
13 RNF32  
Affinity Capture-MS Homo sapiens
14 EBF2  
Affinity Capture-MS Homo sapiens
15 FNDC5  
Affinity Capture-MS Homo sapiens
16 USP36  
Affinity Capture-MS Homo sapiens
17 MBNL1 4154
Affinity Capture-MS Homo sapiens
18 KLK10 5655
Affinity Capture-MS Homo sapiens
19 PINK1  
Affinity Capture-MS Homo sapiens
20 GOT1 2805
Affinity Capture-MS Homo sapiens
21 DLX1  
Affinity Capture-MS Homo sapiens
22 PRKX 5613
Affinity Capture-MS Homo sapiens
23 SMIM8  
Affinity Capture-MS Homo sapiens
24 CCR1  
Affinity Capture-MS Homo sapiens
25 CLCN2  
Affinity Capture-MS Homo sapiens
26 STX17 55014
Affinity Capture-MS Homo sapiens
27 GJB5  
Affinity Capture-MS Homo sapiens
28 LUCAT1  
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which IGLC2 is involved
No pathways found





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