Gene description for IGHA2
Gene name immunoglobulin heavy constant alpha 2 (A2m marker)
Gene symbol IGHA2
Other names/aliases -
Species Homo sapiens
 Database cross references - IGHA2
ExoCarta ExoCarta_3494
Vesiclepedia VP_3494
Entrez Gene 3494
HGNC 5479
MIM 147000
 IGHA2 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells Unpublished / Not applicable
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Saliva 19199708    
Urine 25452312    
 Gene ontology annotations for IGHA2
Molecular Function
    antigen binding GO:0003823 IBA
    antigen binding GO:0003823 TAS
    immunoglobulin receptor binding GO:0034987 IDA
Biological Process
    adaptive immune response GO:0002250 NAS
    glomerular filtration GO:0003094 IMP
    immune response GO:0006955 NAS
    complement activation, classical pathway GO:0006958 IBA
    antibacterial humoral response GO:0019731 IBA
    antibacterial humoral response GO:0019731 IDA
    B cell receptor signaling pathway GO:0050853 NAS
    positive regulation of respiratory burst GO:0060267 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 NAS
    plasma membrane GO:0005886 NAS
    immunoglobulin complex, circulating GO:0042571 IBA
    extracellular exosome GO:0070062 HDA
    IgA immunoglobulin complex GO:0071745 NAS
    monomeric IgA immunoglobulin complex GO:0071748 IDA
    secretory IgA immunoglobulin complex GO:0071751 IDA
    secretory dimeric IgA immunoglobulin complex GO:0071752 IDA
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified IGHA2 in exosomes
1
Experiment ID 494
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
4
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
8
Experiment ID 238
MISEV standards
EM
Biophysical techniques
TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25452312    
Organism Homo sapiens
Experiment description N-linked (N-) glycoproteomics of urimary exosomes
Authors "Saraswat M, Joenvaara S, Musante L, Peltoniemi H4, Holthofer H, Renkonen R."
Journal name Mol Cell Proteomics
Publication year 2014
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Filtration
Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for IGHA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PMEPA1 56937
Affinity Capture-MS Homo sapiens
2 MATN2 4147
Affinity Capture-MS Homo sapiens
3 GNG8  
Affinity Capture-MS Homo sapiens
4 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 WDR6 11180
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PLB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ATP11C 286410
Affinity Capture-MS Homo sapiens
8 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
9 TWF1 5756
Affinity Capture-MS Homo sapiens
10 UQCRQ 27089
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ZNF695  
Affinity Capture-MS Homo sapiens
12 CHAC2 494143
Affinity Capture-MS Homo sapiens
13 SSFA2 6744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 AGPAT1 10554
Affinity Capture-MS Homo sapiens
15 USPL1  
Affinity Capture-MS Homo sapiens
16 DDX3X 1654
Affinity Capture-MS Homo sapiens
17 TMEM176B 28959
Affinity Capture-MS Homo sapiens
18 CRYGN  
Affinity Capture-MS Homo sapiens
19 GALR3  
Affinity Capture-MS Homo sapiens
20 MAGEB4  
Affinity Capture-MS Homo sapiens
21 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 RUNX2  
Affinity Capture-MS Homo sapiens
23 KLF15  
Affinity Capture-MS Homo sapiens
24 UCP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 DXO  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PCK2 5106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PPCS 79717
Affinity Capture-MS Homo sapiens
28 SLC25A15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CIART  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 IGFBP5 3488
Affinity Capture-MS Homo sapiens
31 EBF2  
Affinity Capture-MS Homo sapiens
32 NUAK1  
Affinity Capture-MS Homo sapiens
33 SPNS3  
Affinity Capture-MS Homo sapiens
34 SNF8 11267
Affinity Capture-MS Homo sapiens
35 DNAH17 8632
Affinity Capture-MS Homo sapiens
36 FNDC5  
Affinity Capture-MS Homo sapiens
37 FKBP14  
Affinity Capture-MS Homo sapiens
38 HBQ1  
Affinity Capture-MS Homo sapiens
39 GOLGA8A 23015
Affinity Capture-MS Homo sapiens
40 COG2 22796
Affinity Capture-MS Homo sapiens
41 USB1  
Affinity Capture-MS Homo sapiens
42 SRRT 51593
Affinity Capture-MS Homo sapiens
43 KIR2DS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 FKBP5 2289
Affinity Capture-MS Homo sapiens
45 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 MUC5AC 4586
Affinity Capture-MS Homo sapiens
47 BTBD1  
Affinity Capture-MS Homo sapiens
48 TMEM257  
Affinity Capture-MS Homo sapiens
49 TMEM237 65062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 ZNF491  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CDK14 5218
Affinity Capture-MS Homo sapiens
52 SCAMP2 10066
Affinity Capture-MS Homo sapiens
53 ITLN2  
Affinity Capture-MS Homo sapiens
54 RIBC1  
Affinity Capture-MS Homo sapiens
55 HBM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 RHOBTB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 CDK2AP1  
Affinity Capture-MS Homo sapiens
58 GLRX 2745
Affinity Capture-MS Homo sapiens
59 LRRC8E 80131
Affinity Capture-MS Homo sapiens
60 STK11 6794
Affinity Capture-MS Homo sapiens
61 HINT2 84681
Affinity Capture-MS Homo sapiens
62 PRKX 5613
Affinity Capture-MS Homo sapiens
63 SNW1 22938
Affinity Capture-MS Homo sapiens
64 RHBDD1 84236
Affinity Capture-MS Homo sapiens
65 TIMM10  
Affinity Capture-MS Homo sapiens
66 DDX17 10521
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 APCDD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 OR13C3  
Affinity Capture-MS Homo sapiens
69 NPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 COMMD1 150684
Affinity Capture-MS Homo sapiens
71 TSGA13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 JAK2 3717
Affinity Capture-MS Homo sapiens
73 SFXN4  
Affinity Capture-MS Homo sapiens
74 BRD3 8019
Affinity Capture-MS Homo sapiens
75 GJB5  
Affinity Capture-MS Homo sapiens
76 NMUR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 CCR1  
Affinity Capture-MS Homo sapiens
78 NXT1  
Affinity Capture-MS Homo sapiens
79 TCEB3B  
Affinity Capture-MS Homo sapiens
80 PHF11 51131
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IGHA2 is involved
No pathways found





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