Gene description for MUC5AC
Gene name
mucin 5AC, oligomeric mucus/gel-forming
Gene symbol
MUC5AC
Other names/aliases
MUC5 TBM leB mucin
Species
Homo sapiens
Database cross references - MUC5AC
ExoCarta
ExoCarta_4586
Entrez Gene
4586
HGNC
7515
MIM
158373
MUC5AC identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells
26054723
Saliva
19199708
Gene ontology annotations for MUC5AC
Experiment description of studies that identified MUC5AC in exosomes
1
Experiment ID
235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
26054723
Organism
Homo sapiens
Experiment description
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors
He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name
Carcinogenesis
Publication year
2015
Sample
Hepatocellular carcinoma cells
Sample name
HKCI-8
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.13-1.19 g/mL
Molecules identified in the study
Protein RNA
Methods used in the study
Western blotting Mass spectrometry RT-PCR RNA Sequencing
2
Experiment ID
66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
19199708
Organism
Homo sapiens
Experiment description
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors
Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name
JPR
Publication year
2009
Sample
Saliva
Sample name
Saliva
Isolation/purification methods
Differential centrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [LTQ] Western blotting Immunoelectron Microscopy
Protein-protein interactions for MUC5AC
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
GALNT12
Biochemical Activity
Homo sapiens
2
GALNT14
Biochemical Activity
Homo sapiens
View the network
image/svg+xml
Pathways in which MUC5AC is involved
No pathways found