Gene description for SLC5A1
Gene name solute carrier family 5 (sodium/glucose cotransporter), member 1
Gene symbol SLC5A1
Other names/aliases D22S675
NAGT
SGLT1
Species Homo sapiens
 Database cross references - SLC5A1
ExoCarta ExoCarta_6523
Entrez Gene 6523
HGNC 11036
MIM 182380
UniProt P13866  
 SLC5A1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC5A1
Molecular Function
    protein binding GO:0005515 IPI
    glucose:sodium symporter activity GO:0005412 IDA
Biological Process
    intestinal absorption GO:0050892 IEA
    glucose transport GO:0015758 IMP
    metanephros development GO:0001656 IEA
    sodium ion transport GO:0006814 IEA
    small molecule metabolic process GO:0044281 TAS
    carbohydrate metabolic process GO:0005975 TAS
    hexose transport GO:0008645 TAS
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    extracellular exosome GO:0070062 IDA
    brush border membrane GO:0031526 IEA
    cell-cell junction GO:0005911 IEA
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified SLC5A1 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC5A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPA1A 3303
Affinity Capture-Western Homo sapiens
2 PAWR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SLC5A1 is involved
PathwayEvidenceSource
Hexose transport TAS Reactome
Inositol transporters TAS Reactome
Na+-dependent glucose transporters TAS Reactome





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