Gene description for SLC5A1
Gene name solute carrier family 5 (sodium/glucose cotransporter), member 1
Gene symbol SLC5A1
Other names/aliases D22S675
NAGT
SGLT1
Species Homo sapiens
 Database cross references - SLC5A1
ExoCarta ExoCarta_6523
Vesiclepedia VP_6523
Entrez Gene 6523
HGNC 11036
MIM 182380
UniProt P13866  
 SLC5A1 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC5A1
Molecular Function
    galactose transmembrane transporter activity GO:0005354 ISS
    myo-inositol:sodium symporter activity GO:0005367 ISS
    water transmembrane transporter activity GO:0005372 IDA
    D-glucose:sodium symporter activity GO:0005412 IBA
    D-glucose:sodium symporter activity GO:0005412 IDA
    D-glucose:sodium symporter activity GO:0005412 TAS
    protein binding GO:0005515 IPI
    pentose transmembrane transporter activity GO:0015146 ISS
    fucose transmembrane transporter activity GO:0015150 ISS
    alpha-glucoside transmembrane transporter activity GO:0015151 IDA
    alpha-glucoside transmembrane transporter activity GO:0015151 IMP
    alpha-glucoside transmembrane transporter activity GO:0015151 ISS
    galactose:sodium symporter activity GO:0015371 IDA
    D-glucose transmembrane transporter activity GO:0055056 IDA
Biological Process
    alpha-glucoside transport GO:0000017 IDA
    alpha-glucoside transport GO:0000017 IMP
    alpha-glucoside transport GO:0000017 ISS
    intestinal D-glucose absorption GO:0001951 ISS
    sodium ion transport GO:0006814 IBA
    pentose transmembrane transport GO:0015750 ISS
    fucose transmembrane transport GO:0015756 ISS
    galactose transmembrane transport GO:0015757 ISS
    myo-inositol transport GO:0015798 ISS
    transepithelial water transport GO:0035377 IDA
    renal D-glucose absorption GO:0035623 ISS
    D-glucose import across plasma membrane GO:0098708 IDA
    D-glucose import across plasma membrane GO:0098708 IGI
    sodium ion import across plasma membrane GO:0098719 IDA
    intestinal hexose absorption GO:0106001 TAS
    transport across blood-brain barrier GO:0150104 IGI
    transport across blood-brain barrier GO:0150104 NAS
    chloride transmembrane transport GO:1902476 IDA
    D-glucose transmembrane transport GO:1904659 IDA
    D-glucose transmembrane transport GO:1904659 IMP
Subcellular Localization
    early endosome GO:0005769 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 IDA
    apical plasma membrane GO:0016324 ISS
    brush border membrane GO:0031526 ISS
    intracellular organelle GO:0043229 ISS
    perinuclear region of cytoplasm GO:0048471 IDA
    extracellular exosome GO:0070062 HDA
    intracellular vesicle GO:0097708 TAS
 Experiment description of studies that identified SLC5A1 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC5A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MUC5AC 4586
Affinity Capture-MS Homo sapiens
2 PAWR 5074
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 DDX58 23586
Affinity Capture-RNA Homo sapiens
4 CD63 967
Affinity Capture-MS Homo sapiens
5 HSPA1A 3303
Affinity Capture-Western Homo sapiens
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