Gene description for CDK14
Gene name cyclin-dependent kinase 14
Gene symbol CDK14
Other names/aliases PFTAIRE1
PFTK1
Species Homo sapiens
 Database cross references - CDK14
ExoCarta ExoCarta_5218
Entrez Gene 5218
HGNC 8883
MIM 610679
UniProt O94921  
 CDK14 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for CDK14
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IMP
    cyclin binding GO:0030332 IPI
Biological Process
    G2/M transition of mitotic cell cycle GO:0000086 IDA
    regulation of cell cycle GO:0051726 IMP
    protein phosphorylation GO:0006468 IEA
    Wnt signaling pathway GO:0016055 IEA
    regulation of canonical Wnt signaling pathway GO:0060828 IDA
    cell division GO:0051301 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IEA
    cytoplasm GO:0005737 IDA
    cytoplasmic cyclin-dependent protein kinase holoenzyme complex GO:0000308 IDA
 Experiment description of studies that identified CDK14 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDK14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEPT8 23176
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 IGHA2 3494
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CDK14 is involved
No pathways found





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