Gene description for FGR
Gene name	FGR proto-oncogene, Src family tyrosine kinase
Gene symbol	FGR
Other names/aliases	SRC2 c-fgr c-src2 p55-Fgr p55c-fgr p58-Fgr p58c-fgr
Species	Homo sapiens
Database cross references - FGR
ExoCarta	ExoCarta_2268
Entrez Gene	2268
HGNC	3697
MIM	164940
UniProt	P09769
FGR identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
Hepatocytes	26054723
Neuroblastoma cells	25944692
Platelets	25332113
Platelets	25332113
Platelets	25332113
Squamous carcinoma cells	20124223

Gene ontology annotations for FGR

Molecular Function     immunoglobulin receptor binding GO:0034987 ISS     phosphotyrosine binding GO:0001784 ISS     ATP binding GO:0005524 IEA     protein binding GO:0005515 IPI     protein tyrosine kinase activity GO:0004713 IDA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA     protein kinase binding GO:0019901 ISS     Fc-gamma receptor I complex binding GO:0034988 IDA Biological Process     regulation of cell shape GO:0008360 ISS     peptidyl-tyrosine phosphorylation GO:0018108 IDA     integrin-mediated signaling pathway GO:0007229 ISS     protein phosphorylation GO:0006468 TAS     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IMP     response to virus GO:0009615 TAS     regulation of innate immune response GO:0045088 ISS     regulation of protein kinase activity GO:0045859 ISS     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     blood coagulation GO:0007596 TAS     positive regulation of cell migration GO:0030335 ISS     immune response-regulating cell surface receptor signaling pathway GO:0002768 TAS     innate immune response GO:0045087 TAS     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     protein autophosphorylation GO:0046777 IDA     positive regulation of cytokine secretion GO:0050715 ISS     cellular response to peptide hormone stimulus GO:0071375 IBA     regulation of cell proliferation GO:0042127 IBA     regulation of phagocytosis GO:0050764 ISS     cell differentiation GO:0030154 IBA     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IMP     positive regulation of mast cell degranulation GO:0043306 ISS     defense response to Gram-positive bacterium GO:0050830 ISS Subcellular Localization     mitochondrial intermembrane space GO:0005758 IEA     ruffle membrane GO:0032587 ISS     plasma membrane GO:0005886 ISS     mitochondrial inner membrane GO:0005743 IEA     cytoskeleton GO:0005856 IDA     actin cytoskeleton GO:0015629 ISS     cytosol GO:0005829 TAS     extracellular exosome GO:0070062 IDA     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA