Gene description for CDK18
Gene name cyclin-dependent kinase 18
Gene symbol CDK18
Other names/aliases PCTAIRE
PCTAIRE3
PCTK3
Species Homo sapiens
 Database cross references - CDK18
ExoCarta ExoCarta_5129
Entrez Gene 5129
HGNC 8751
MIM 169190
UniProt Q07002  
 CDK18 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for CDK18
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IEA
Biological Process
    protein phosphorylation GO:0006468 IEA
    regulation of cell cycle GO:0051726 IEA
Subcellular Localization
    cellular_component GO:0005575 ND
 Experiment description of studies that identified CDK18 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDK18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DIPA  
Two-hybrid Homo sapiens
2 CCNK  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CDK18 is involved
No pathways found





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