Gene description for CDK5
Gene name	cyclin-dependent kinase 5
Gene symbol	CDK5
Other names/aliases	LIS7 PSSALRE
Species	Homo sapiens
Database cross references - CDK5
ExoCarta	ExoCarta_1020
Entrez Gene	1020
HGNC	1774
MIM	123831
UniProt	Q00535
CDK5 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for CDK5

Molecular Function     tau-protein kinase activity GO:0050321 ISS     ErbB-2 class receptor binding GO:0005176 ISS     p53 binding GO:0002039 IEA     protein binding GO:0005515 IPI     ErbB-3 class receptor binding GO:0043125 ISS     ephrin receptor binding GO:0046875 IEA     cytoskeletal protein binding GO:0008092 IEA     cyclin-dependent protein serine/threonine kinase activity GO:0004693 IEA     ATP binding GO:0005524 IEA     kinase activity GO:0016301 ISS     protein kinase activity GO:0004672 TAS     protein serine/threonine kinase activity GO:0004674 TAS     acetylcholine receptor activator activity GO:0030549 ISS Biological Process     neuron differentiation GO:0030182 TAS     axon extension GO:0048675 TAS     cell cycle GO:0007049 IEA     peptidyl-threonine phosphorylation GO:0018107 IEA     negative regulation of axon extension GO:0030517 IEA     neuron projection development GO:0031175 ISS     synaptic vesicle endocytosis GO:0048488 TAS     skeletal muscle tissue development GO:0007519 IEA     phosphorylation GO:0016310 IDA     negative regulation of cell cycle GO:0045786 IEA     regulation of cell migration GO:0030334 IEA     positive regulation of protein targeting to membrane GO:0090314 IEA     positive regulation of neuron apoptotic process GO:0043525 ISS     negative regulation of protein ubiquitination GO:0031397 IEA     protein localization to synapse GO:0035418 IEA     layer formation in cerebral cortex GO:0021819 IEA     behavioral response to cocaine GO:0048148 IEA     synaptic transmission GO:0007268 TAS     cell division GO:0051301 IEA     regulated secretory pathway GO:0045055 IEA     synaptic transmission, dopaminergic GO:0001963 IEA     negative regulation of transcription, DNA-templated GO:0045892 IMP     regulation of apoptotic process GO:0042981 TAS     cortical actin cytoskeleton organization GO:0030866 IEA     receptor clustering GO:0043113 IEA     negative regulation of proteolysis GO:0045861 IMP     peptidyl-serine phosphorylation GO:0018105 IDA     Schwann cell development GO:0014044 IEA     regulation of synaptic vesicle recycling GO:1903421 NAS     positive regulation of protein kinase activity GO:0045860 IEA     regulation of excitatory postsynaptic membrane potential GO:0060079 IEA     regulation of cell cycle arrest GO:0071156 TAS     positive regulation of receptor activity GO:2000273 IEA     cerebellar cortex formation GO:0021697 IEA     synaptic vesicle exocytosis GO:0016079 TAS     protein autophosphorylation GO:0046777 IEA     embryo development GO:0009790 IEA     synapse assembly GO:0007416 TAS     regulation of dendritic spine morphogenesis GO:0061001 ISS     neuron migration GO:0001764 TAS     sensory perception of pain GO:0019233 IEA     cell proliferation GO:0008283 TAS     serine phosphorylation of STAT3 protein GO:0033136 IEA     cell-matrix adhesion GO:0007160 IEA     rhythmic process GO:0048511 IEA     negative regulation of synaptic plasticity GO:0031914 IEA     positive regulation of calcium ion-dependent exocytosis GO:0045956 IEA     positive regulation of protein binding GO:0032092 IEA     negative regulation of protein export from nucleus GO:0046826 IEA     hippocampus development GO:0021766 IEA     dendrite morphogenesis GO:0048813 IEA     visual learning GO:0008542 IEA     receptor catabolic process GO:0032801 IEA     motor neuron axon guidance GO:0008045 IEA     intracellular protein transport GO:0006886 IEA     axon guidance GO:0007411 TAS     regulation of synaptic plasticity GO:0048167 TAS     positive regulation of actin cytoskeleton reorganization GO:2000251 TAS     central nervous system neuron development GO:0021954 IEA     oligodendrocyte differentiation GO:0048709 IDA     neuron apoptotic process GO:0051402 TAS     blood coagulation GO:0007596 TAS     calcium ion import GO:0070509 IEA     nucleocytoplasmic transport GO:0006913 IEA     corpus callosum development GO:0022038 IEA     synaptic transmission, glutamatergic GO:0035249 IEA     negative regulation of neuron death GO:1901215 IDA Subcellular Localization     cytoplasm GO:0005737 ISS     axon GO:0030424 ISS     dendrite GO:0030425 ISS     nucleus GO:0005634 ISS     filopodium GO:0030175 IEA     membrane GO:0016020 ISS     postsynaptic membrane GO:0045211 IEA     neuronal cell body GO:0043025 ISS     growth cone GO:0030426 ISS     cytoskeleton GO:0005856 IEA     neuromuscular junction GO:0031594 ISS     postsynaptic density GO:0014069 ISS     perikaryon GO:0043204 IEA     cell junction GO:0030054 IEA     lamellipodium GO:0030027 IEA     cytosol GO:0005829 TAS     cyclin-dependent protein kinase 5 holoenzyme complex GO:0016533 IEA