Gene description for SCYL2
Gene name SCY1-like 2 (S. cerevisiae)
Gene symbol SCYL2
Other names/aliases CVAK104
Species Homo sapiens
 Database cross references - SCYL2
ExoCarta ExoCarta_55681
Vesiclepedia VP_55681
Entrez Gene 55681
HGNC 19286
MIM 616365
UniProt Q6P3W7  
 SCYL2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SCYL2
Molecular Function
    protein kinase activity GO:0004672 IEA
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
Biological Process
    brain development GO:0007420 ISS
    endosome to lysosome transport GO:0008333 IDA
    pyramidal neuron development GO:0021860 ISS
    receptor internalization GO:0031623 IDA
    clathrin-dependent endocytosis GO:0072583 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    endosome membrane GO:0010008 IEA
    clathrin-coated vesicle GO:0030136 IEA
 Experiment description of studies that identified SCYL2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SCYL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 AP2B1 163
Proximity Label-MS Homo sapiens
3 MARCKS 4082
Proximity Label-MS Homo sapiens
4 LAMP3  
Proximity Label-MS Homo sapiens
5 ATG9A 79065
Proximity Label-MS Homo sapiens
6 GJA1 2697
Proximity Label-MS Homo sapiens
7 SUB1 10923
Affinity Capture-MS Homo sapiens
8 NOP56 10528
Affinity Capture-MS Homo sapiens
9 CRY1  
Affinity Capture-MS Homo sapiens
10 LAMP2 3920
Proximity Label-MS Homo sapiens
11 CLTB 1212
Proximity Label-MS Homo sapiens
12 USP36  
Affinity Capture-MS Homo sapiens
13 KIAA1429 25962
Affinity Capture-MS Homo sapiens
14 HSPA2 3306
Affinity Capture-MS Homo sapiens
15 PFKFB2 5208
Affinity Capture-MS Homo sapiens
16 STK38L 23012
Affinity Capture-MS Homo sapiens
17 RAB3B 5865
Proximity Label-MS Homo sapiens
18 DDRGK1 65992
Affinity Capture-MS Homo sapiens
19 OBSL1 23363
Affinity Capture-MS Homo sapiens
20 STX6 10228
Proximity Label-MS Homo sapiens
21 SARNP 84324
Affinity Capture-MS Homo sapiens
22 SEPT7 989
Affinity Capture-MS Homo sapiens
23 GTSE1 51512
Affinity Capture-MS Homo sapiens
24 PRCC  
Affinity Capture-MS Homo sapiens
25 RAB35 11021
Proximity Label-MS Homo sapiens
26 COX17  
Co-fractionation Homo sapiens
27 GORASP1 64689
Proximity Label-MS Homo sapiens
28 ZFYVE9  
Two-hybrid Homo sapiens
29 AMOT  
Proximity Label-MS Homo sapiens
30 SOD1 6647
Co-fractionation Homo sapiens
31 PDLIM1 9124
Affinity Capture-MS Homo sapiens
32 LAMTOR1 55004
Proximity Label-MS Homo sapiens
33 HSPA8 3312
Affinity Capture-MS Homo sapiens
34 NUP155 9631
Proximity Label-MS Homo sapiens
35 PFN1 5216
Proximity Label-MS Homo sapiens
36 CHMP4C 92421
Affinity Capture-MS Homo sapiens
37 KRT8 3856
Proximity Label-MS Homo sapiens
38 MIB1 57534
Proximity Label-MS Homo sapiens
39 COX15 1355
Affinity Capture-MS Homo sapiens
40 PRPH 5630
Proximity Label-MS Homo sapiens
41 PARK2  
Affinity Capture-MS Homo sapiens
42 CDK5 1020
Affinity Capture-MS Homo sapiens
43 SPATA1  
Affinity Capture-MS Homo sapiens
44 PSMD14 10213
Affinity Capture-MS Homo sapiens
45 RAB4A 5867
Proximity Label-MS Homo sapiens
46 CDH1 999
Proximity Label-MS Homo sapiens
47 DIRAS3  
Proximity Label-MS Homo sapiens
48 NTRK1 4914
Affinity Capture-MS Homo sapiens
49 GORASP2 26003
Affinity Capture-MS Homo sapiens
50 PEX14 5195
Proximity Label-MS Homo sapiens
51 NSRP1  
Affinity Capture-MS Homo sapiens
52 CHORDC1 26973
Affinity Capture-MS Homo sapiens
53 TPP2 7174
Affinity Capture-MS Homo sapiens
54 TGM1 7051
Affinity Capture-MS Homo sapiens
55 MAGOH 4116
Affinity Capture-MS Homo sapiens
56 RHOT2 89941
Proximity Label-MS Homo sapiens
57 RMDN3 55177
Proximity Label-MS Homo sapiens
58 PCBP2 5094
Co-fractionation Homo sapiens
59 CLINT1 9685
Affinity Capture-MS Homo sapiens
60 XPO1 7514
Affinity Capture-MS Homo sapiens
61 BAG2 9532
Affinity Capture-MS Homo sapiens
62 UBAP2 55833
Affinity Capture-MS Homo sapiens
63 RAB11A 8766
Proximity Label-MS Homo sapiens
64 AKAP9 10142
Affinity Capture-MS Homo sapiens
65 PTEN 5728
Affinity Capture-MS Homo sapiens
66 EGFR 1956
Affinity Capture-MS Homo sapiens
67 FBXO6 26270
Affinity Capture-MS Homo sapiens
68 SEPT11 55752
Affinity Capture-MS Homo sapiens
69 OCIAD1 54940
Proximity Label-MS Homo sapiens
70 TGM7  
Affinity Capture-MS Homo sapiens
71 CUL9  
Affinity Capture-MS Homo sapiens
72 SOAT1 6646
Affinity Capture-MS Homo sapiens
73 RAPGEF2 9693
Affinity Capture-MS Homo sapiens
74 SPEN 23013
Co-fractionation Homo sapiens
75 BAG1 573
Affinity Capture-MS Homo sapiens
76 DIS3 22894
Affinity Capture-MS Homo sapiens
77 RAB9A 9367
Proximity Label-MS Homo sapiens
78 HSPA1A 3303
Affinity Capture-MS Homo sapiens
79 MOB2 81532
Affinity Capture-MS Homo sapiens
80 EBAG9 9166
Proximity Label-MS Homo sapiens
81 RHOB 388
Proximity Label-MS Homo sapiens
82 VDAC1 7416
Affinity Capture-MS Homo sapiens
83 CLTC 1213
Affinity Capture-MS Homo sapiens
84 AKAP1 8165
Proximity Label-MS Homo sapiens
85 EIF3H 8667
Affinity Capture-MS Homo sapiens
86 ARRB2 409
Affinity Capture-MS Homo sapiens
87 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
88 COPZ1 22818
Affinity Capture-MS Homo sapiens
89 TP53 7157
Affinity Capture-MS Homo sapiens
90 PCMT1 5110
Co-fractionation Homo sapiens
91 TALDO1 6888
Co-fractionation Homo sapiens
92 POLE3  
Affinity Capture-MS Homo sapiens
93 CTSD 1509
Co-fractionation Homo sapiens
94 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
95 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
96 TKT 7086
Co-fractionation Homo sapiens
97 EIF4A3 9775
Affinity Capture-MS Homo sapiens
98 C11orf52 91894
Proximity Label-MS Homo sapiens
99 CDK1 983
Affinity Capture-MS Homo sapiens
100 POU2F1 5451
Affinity Capture-MS Homo sapiens
101 ESR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 UFL1 23376
Affinity Capture-MS Homo sapiens
103 RAB5A 5868
Proximity Label-MS Homo sapiens
104 COQ2  
Affinity Capture-MS Homo sapiens
105 TRIM37  
Proximity Label-MS Homo sapiens
106 ALYREF 10189
Affinity Capture-MS Homo sapiens
107 ARRB1 408
Affinity Capture-MS Homo sapiens
108 SH3GLB1 51100
Affinity Capture-MS Homo sapiens
109 PXN 5829
Proximity Label-MS Homo sapiens
110 CLTA 1211
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 SNW1 22938
Affinity Capture-MS Homo sapiens
112 RPA3 6119
Proximity Label-MS Homo sapiens
113 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SCYL2 is involved
No pathways found





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