Gene description for SCYL2
Gene name SCY1-like 2 (S. cerevisiae)
Gene symbol SCYL2
Other names/aliases CVAK104
Species Homo sapiens
 Database cross references - SCYL2
ExoCarta ExoCarta_55681
Entrez Gene 55681
HGNC 19286
MIM 616365
UniProt Q6P3W7  
 SCYL2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SCYL2
Molecular Function
    ATP binding GO:0005524 IEA
    protein kinase activity GO:0004672 IEA
    receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of clathrin-mediated endocytosis GO:2000370 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    protein phosphorylation GO:0006468 IEA
    endosome to lysosome transport GO:0008333 IDA
    positive regulation of receptor internalization GO:0002092 IDA
    receptor internalization involved in canonical Wnt signaling pathway GO:2000286 IDA
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    clathrin-coated vesicle GO:0030136 IEA
    endosome membrane GO:0010008 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified SCYL2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SCYL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SCYL2 is involved
No pathways found





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