Gene description for DIS3
Gene name DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
Gene symbol DIS3
Other names/aliases 2810028N01Rik
EXOSC11
KIAA1008
RRP44
dis3p
Species Homo sapiens
 Database cross references - DIS3
ExoCarta ExoCarta_22894
Entrez Gene 22894
HGNC 20604
MIM 607533
UniProt Q9Y2L1  
 DIS3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for DIS3
Molecular Function
    protein binding GO:0005515 IPI
    RNA binding GO:0003723 IEA
    3'-5'-exoribonuclease activity GO:0000175 IMP
    endonuclease activity GO:0004519 IMP
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
Biological Process
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0043928 TAS
    rRNA processing GO:0006364 TAS
    positive regulation of GTPase activity GO:0043547 IDA
    nucleic acid phosphodiester bond hydrolysis GO:0090305 IMP
    CUT catabolic process GO:0071034 IMP
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    RNA phosphodiester bond hydrolysis, exonucleolytic GO:0090503 IMP
    gene expression GO:0010467 TAS
    rRNA catabolic process GO:0016075 IMP
    mRNA catabolic process GO:0006402 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    nuclear exosome (RNase complex) GO:0000176 IDA
    cytosol GO:0005829 TAS
    exosome (RNase complex) GO:0000178 TAS
    membrane GO:0016020 IDA
    cytoplasmic exosome (RNase complex) GO:0000177 IBA
 Experiment description of studies that identified DIS3 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DIS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZBTB17  
Two-hybrid Homo sapiens
View the network image/svg+xml



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