Gene description for WIF1
Gene name WNT inhibitory factor 1
Gene symbol WIF1
Other names/aliases WIF-1
Species Homo sapiens
 Database cross references - WIF1
ExoCarta ExoCarta_11197
Vesiclepedia VP_11197
Entrez Gene 11197
HGNC 18081
MIM 605186
UniProt Q9Y5W5  
 WIF1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for WIF1
Molecular Function
    signaling receptor binding GO:0005102 IBA
    protein binding GO:0005515 IPI
    Wnt-protein binding GO:0017147 NAS
Biological Process
    signal transduction GO:0007165 NAS
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of Wnt signaling pathway GO:0030178 NAS
    positive regulation of fat cell differentiation GO:0045600 IEA
Subcellular Localization
    extracellular region GO:0005576 IBA
    cell surface GO:0009986 IBA
 Experiment description of studies that identified WIF1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for WIF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
2 SPATS2  
Affinity Capture-MS Homo sapiens
3 F11R 50848
Affinity Capture-MS Homo sapiens
4 GTF2F1 2962
Affinity Capture-MS Homo sapiens
5 SNX3 8724
Affinity Capture-MS Homo sapiens
6 NDRG1 10397
Affinity Capture-MS Homo sapiens
7 CTBP2 1488
Affinity Capture-MS Homo sapiens
8 GAMT  
Affinity Capture-MS Homo sapiens
9 PBK  
Affinity Capture-MS Homo sapiens
10 ZFR 51663
Affinity Capture-MS Homo sapiens
11 GCLM 2730
Affinity Capture-MS Homo sapiens
12 PTPN1 5770
Affinity Capture-MS Homo sapiens
13 PRPF40A 55660
Affinity Capture-MS Homo sapiens
14 SNX6 58533
Affinity Capture-MS Homo sapiens
15 CWF19L1 55280
Affinity Capture-MS Homo sapiens
16 TOMM22 56993
Affinity Capture-MS Homo sapiens
17 HCCS 3052
Affinity Capture-MS Homo sapiens
18 ADK 132
Affinity Capture-MS Homo sapiens
19 PTRH2 51651
Affinity Capture-MS Homo sapiens
20 RBM15 64783
Affinity Capture-MS Homo sapiens
21 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
22 USO1 8615
Affinity Capture-MS Homo sapiens
23 RAP1BL 643752
Affinity Capture-MS Homo sapiens
24 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
25 TLN1 7094
Affinity Capture-MS Homo sapiens
26 HDLBP 3069
Affinity Capture-MS Homo sapiens
27 SH3BP1 23616
Affinity Capture-MS Homo sapiens
28 SUPV3L1 6832
Affinity Capture-MS Homo sapiens
29 CPSF7 79869
Affinity Capture-MS Homo sapiens
30 POLR1E  
Affinity Capture-MS Homo sapiens
31 ARMT1 79624
Affinity Capture-MS Homo sapiens
32 PRPS1 5631
Affinity Capture-MS Homo sapiens
33 RAB5B 5869
Affinity Capture-MS Homo sapiens
34 PGRMC2 10424
Affinity Capture-MS Homo sapiens
35 VAPB 9217
Affinity Capture-MS Homo sapiens
36 TRMT1 55621
Affinity Capture-MS Homo sapiens
37 TOMM40 10452
Affinity Capture-MS Homo sapiens
38 TFCP2 7024
Affinity Capture-MS Homo sapiens
39 RMDN1 51115
Affinity Capture-MS Homo sapiens
40 UQCRQ 27089
Affinity Capture-MS Homo sapiens
41 EHD1 10938
Affinity Capture-MS Homo sapiens
42 CTSV 1515
Affinity Capture-MS Homo sapiens
43 ADSL 158
Affinity Capture-MS Homo sapiens
44 EDC4 23644
Affinity Capture-MS Homo sapiens
45 MTCH2 23788
Affinity Capture-MS Homo sapiens
46 NOMO1 23420
Affinity Capture-MS Homo sapiens
47 MAPK3 5595
Affinity Capture-MS Homo sapiens
48 NAA50 80218
Affinity Capture-MS Homo sapiens
49 CCDC6 8030
Affinity Capture-MS Homo sapiens
50 TBL2 26608
Affinity Capture-MS Homo sapiens
51 SUPT5H 6829
Affinity Capture-MS Homo sapiens
52 RECQL 5965
Affinity Capture-MS Homo sapiens
53 GALE 2582
Affinity Capture-MS Homo sapiens
54 LETM1 3954
Affinity Capture-MS Homo sapiens
55 CYB5A 1528
Affinity Capture-MS Homo sapiens
56 YAP1 10413
Affinity Capture-MS Homo sapiens
57 PDS5A 23244
Affinity Capture-MS Homo sapiens
58 SYNJ2BP 55333
Affinity Capture-MS Homo sapiens
59 CYSRT1 375791
Two-hybrid Homo sapiens
60 CKAP5 9793
Affinity Capture-MS Homo sapiens
61 HMOX2 3163
Affinity Capture-MS Homo sapiens
62 TRIP10 9322
Affinity Capture-MS Homo sapiens
63 ZMPSTE24 10269
Affinity Capture-MS Homo sapiens
64 UBTF 7343
Affinity Capture-MS Homo sapiens
65 AP3B1 8546
Affinity Capture-MS Homo sapiens
66 FAM49B 51571
Affinity Capture-MS Homo sapiens
67 CSTF3 1479
Affinity Capture-MS Homo sapiens
68 PICALM 8301
Affinity Capture-MS Homo sapiens
69 DNM1L 10059
Affinity Capture-MS Homo sapiens
70 TTLL12 23170
Affinity Capture-MS Homo sapiens
71 STAM 8027
Affinity Capture-MS Homo sapiens
72 PPP1R8 5511
Affinity Capture-MS Homo sapiens
73 CD3EAP  
Affinity Capture-MS Homo sapiens
74 SNX1 6642
Affinity Capture-MS Homo sapiens
75 RNF40 9810
Affinity Capture-MS Homo sapiens
76 SGPL1 8879
Affinity Capture-MS Homo sapiens
77 SMCHD1 23347
Affinity Capture-MS Homo sapiens
78 PNPT1 87178
Affinity Capture-MS Homo sapiens
79 RAB5A 5868
Affinity Capture-MS Homo sapiens
80 RAB13 5872
Affinity Capture-MS Homo sapiens
81 UBXN7 26043
Affinity Capture-MS Homo sapiens
82 KRTAP10-8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
83 SYMPK 8189
Affinity Capture-MS Homo sapiens
84 PRPSAP2 5636
Affinity Capture-MS Homo sapiens
85 NAA15 80155
Affinity Capture-MS Homo sapiens
86 NFS1 9054
Affinity Capture-MS Homo sapiens
87 HSPA14 51182
Affinity Capture-MS Homo sapiens
88 KRTAP10-3  
Two-hybrid Homo sapiens
89 PDCD11 22984
Affinity Capture-MS Homo sapiens
90 RDH11 51109
Affinity Capture-MS Homo sapiens
91 RFC1 5981
Affinity Capture-MS Homo sapiens
92 SF3A1 10291
Affinity Capture-MS Homo sapiens
93 NT5C2 22978
Affinity Capture-MS Homo sapiens
94 RBM26 64062
Affinity Capture-MS Homo sapiens
95 NDUFB3 4709
Affinity Capture-MS Homo sapiens
96 DIS3 22894
Affinity Capture-MS Homo sapiens
97 TERF2  
Affinity Capture-MS Homo sapiens
98 GSTK1 373156
Affinity Capture-MS Homo sapiens
99 NMD3 51068
Affinity Capture-MS Homo sapiens
100 FKBP3 2287
Affinity Capture-MS Homo sapiens
101 DDX52  
Affinity Capture-MS Homo sapiens
102 ICOS  
Two-hybrid Homo sapiens
103 NAA10 8260
Affinity Capture-MS Homo sapiens
104 PPME1 51400
Affinity Capture-MS Homo sapiens
105 U2SURP 23350
Affinity Capture-MS Homo sapiens
106 TXLNA 200081
Affinity Capture-MS Homo sapiens
107 RPL37 6167
Two-hybrid Homo sapiens
108 WNT1  
Affinity Capture-Western Homo sapiens
109 STK24 8428
Affinity Capture-MS Homo sapiens
110 TSFM 10102
Affinity Capture-MS Homo sapiens
111 EHD4 30844
Affinity Capture-MS Homo sapiens
112 MAP1S 55201
Affinity Capture-MS Homo sapiens
113 RBM25 58517
Affinity Capture-MS Homo sapiens
114 LARS2 23395
Affinity Capture-MS Homo sapiens
115 SNCG 6623
Affinity Capture-MS Homo sapiens
116 IL27  
Affinity Capture-MS Homo sapiens
117 OXSR1 9943
Affinity Capture-MS Homo sapiens
118 NDUFA12 55967
Affinity Capture-MS Homo sapiens
119 IDH2 3418
Affinity Capture-MS Homo sapiens
120 TBL3 10607
Affinity Capture-MS Homo sapiens
121 NUP35 129401
Affinity Capture-MS Homo sapiens
122 MAP2K1 5604
Affinity Capture-MS Homo sapiens
123 IP6K1 9807
Affinity Capture-MS Homo sapiens
124 SFXN1 94081
Affinity Capture-MS Homo sapiens
125 UFL1 23376
Affinity Capture-MS Homo sapiens
126 RAB8A 4218
Affinity Capture-MS Homo sapiens
127 MBNL1 4154
Affinity Capture-MS Homo sapiens
128 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
129 IK 3550
Affinity Capture-MS Homo sapiens
130 TBRG4 9238
Affinity Capture-MS Homo sapiens
131 SH3GLB1 51100
Affinity Capture-MS Homo sapiens
132 MGME1  
Affinity Capture-MS Homo sapiens
133 CYB5R3 1727
Affinity Capture-MS Homo sapiens
134 RPRD1B 58490
Affinity Capture-MS Homo sapiens
135 UBLCP1  
Affinity Capture-MS Homo sapiens
136 CKAP4 10970
Affinity Capture-MS Homo sapiens
137 EMG1 10436
Affinity Capture-MS Homo sapiens
138 MGST3 4259
Affinity Capture-MS Homo sapiens
139 NAE1 8883
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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