Gene description for SNCG
Gene name synuclein, gamma (breast cancer-specific protein 1)
Gene symbol SNCG
Other names/aliases BCSG1
SR
Species Homo sapiens
 Database cross references - SNCG
ExoCarta ExoCarta_6623
Entrez Gene 6623
HGNC 11141
MIM 602998
UniProt O76070  
 SNCG identified in exosomes derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for SNCG
Molecular Function
    alpha-tubulin binding GO:0043014 IEA
    beta-tubulin binding GO:0048487 IEA
Biological Process
    aggressive behavior GO:0002118 IEA
    response to drug GO:0042493 IEA
    protein secretion GO:0009306 IEA
    adult locomotory behavior GO:0008344 IEA
    cellular response to hydrostatic pressure GO:0071464 IEA
    regulation of dopamine secretion GO:0014059 IEA
    regulation of neurotransmitter secretion GO:0046928 IEA
    response to cocaine GO:0042220 IEA
    synapse organization GO:0050808 IEA
    synaptic transmission GO:0007268 IEA
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IEA
    microtubule organizing center GO:0005815 IEA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    axon terminus GO:0043679 IEA
    plasma membrane GO:0005886 IEA
    neuronal cell body GO:0043025 IEA
    spindle GO:0005819 IEA
 Experiment description of studies that identified SNCG in exosomes
1
Experiment ID 13
ISEV standards
IEM
EV Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101
EV Cytosolic markers
CD9|AQP2|AQP1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors Pisitkun T, Shen RF, Knepper MA
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SNCG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK1 5594
Affinity Capture-Western Homo sapiens
2 FABP4  
Affinity Capture-MS Homo sapiens
3 GRK5 2869
Invitro Homo sapiens
4 HNF4A  
Affinity Capture-MS Homo sapiens
5 MCM3 4172
Affinity Capture-MS Homo sapiens
6 MAPK3 5595
Affinity Capture-Western Homo sapiens
7 BUB1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
8 EXT2 2132
Affinity Capture-MS Homo sapiens
9 MAPK8 5599
Affinity Capture-Western Homo sapiens
10 FUBP1 8880
Affinity Capture-MS Homo sapiens
11 TIMP2 7077
Affinity Capture-MS Homo sapiens
12 DYNLL1 8655
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SNCG is involved
No pathways found





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