Gene description for ADRBK1
Gene name adrenergic, beta, receptor kinase 1
Gene symbol ADRBK1
Other names/aliases GRK2
Species Bos taurus
 Database cross references - ADRBK1
ExoCarta ExoCarta_282682
Entrez Gene 282682
UniProt P21146  
 ADRBK1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ADRBK1
Molecular Function
    G-protein coupled receptor kinase activity GO:0004703 ISS
    alpha-2A adrenergic receptor binding GO:0031694 IPI
    protein kinase activity GO:0004672 ISS
    ATP binding GO:0005524 IEA
    beta-adrenergic receptor kinase activity GO:0047696 IEA
    Edg-2 lysophosphatidic acid receptor binding GO:0031755 ISS
    protein binding GO:0005515 IPI
Biological Process
    cardiac muscle contraction GO:0060048 IMP
    G-protein coupled receptor signaling pathway GO:0007186 ISS
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
    desensitization of G-protein coupled receptor protein signaling pathway GO:0002029 ISS
    intracellular protein transport GO:0006886 IMP
    peptidyl-threonine phosphorylation GO:0018107 IEA
    protein phosphorylation GO:0006468 ISS
    negative regulation of the force of heart contraction by chemical signal GO:0003108 IMP
    negative regulation of striated muscle contraction GO:0045988 IMP
    G-protein coupled receptor internalization GO:0002031 IDA
    peptidyl-serine phosphorylation GO:0018105 IDA
    regulation of the force of heart contraction GO:0002026 ISS
    heart development GO:0007507 ISS
    G-protein coupled acetylcholine receptor signaling pathway GO:0007213 IDA
    regulation of signal transduction GO:0009966 IMP
    tachykinin receptor signaling pathway GO:0007217 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    cytosol GO:0005829 IDA
    membrane GO:0016020 ISS
 Experiment description of studies that identified ADRBK1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ADRBK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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