Gene description for TERF1
Gene name telomeric repeat binding factor (NIMA-interacting) 1
Gene symbol TERF1
Other names/aliases PIN2
TRBF1
TRF
TRF1
hTRF1-AS
t-TRF1
Species Homo sapiens
 Database cross references - TERF1
ExoCarta ExoCarta_7013
Vesiclepedia VP_7013
Entrez Gene 7013
HGNC 11728
MIM 600951
UniProt P54274  
 TERF1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TERF1
Molecular Function
    microtubule binding GO:0008017 IDA
    protein homodimerization activity GO:0042803 IPI
    chromatin binding GO:0003682 IEA
    DNA binding GO:0003677 NAS
    protein heterodimerization activity GO:0046982 IDA
    telomeric DNA binding GO:0042162 IDA
    double-stranded telomeric DNA binding GO:0003691 IDA
    DNA binding, bending GO:0008301 IDA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of mitotic cell cycle GO:0045931 IMP
    positive regulation of apoptotic process GO:0043065 IDA
    mitotic spindle assembly checkpoint GO:0007094 IMP
    response to drug GO:0042493 IEA
    negative regulation of DNA replication GO:0008156 IDA
    negative regulation of telomere maintenance via semi-conservative replication GO:0032214 NAS
    protein homooligomerization GO:0051260 IDA
    telomere maintenance via telomerase GO:0007004 NAS
    cell division GO:0051301 IEA
    telomere maintenance GO:0000723 TAS
    positive regulation of mitotic nuclear division GO:0045840 IMP
    negative regulation of telomerase activity GO:0051974 IGI
    mitotic nuclear division GO:0007067 IEA
    positive regulation of microtubule polymerization GO:0031116 IDA
    telomeric loop formation GO:0031627 IBA
    G2/M transition of mitotic cell cycle GO:0000086 IEP
    negative regulation of telomere maintenance via telomerase GO:0032211 IGI
Subcellular Localization
    nuclear telomere cap complex GO:0000783 ISS
    spindle GO:0005819 IEA
    nucleus GO:0005634 NAS
    nuclear chromosome, telomeric region GO:0000784 IBA
    chromosome, telomeric region GO:0000781 IDA
    cytoplasm GO:0005737 IEA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified TERF1 in exosomes
1
Experiment ID 126
MISEV standards
EV Biophysical techniques
GAPDH
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TERF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACD  
Affinity Capture-Western Homo sapiens
2 PFN2 5217
Two-hybrid Homo sapiens
3 DLG5 9231
Two-hybrid Homo sapiens
4 MAPRE1 22919
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
5 POT1  
Affinity Capture-Western Homo sapiens
6 ZHX1  
Two-hybrid Homo sapiens
7 TNKS 8658
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 KPNB1 3837
Reconstituted Complex Homo sapiens
9 UTP14A 10813
Two-hybrid Homo sapiens
10 ABL1 25
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 ATM 472
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
12 PINX1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 CAPNS1 826
Two-hybrid Homo sapiens
14 ZBTB16  
Two-hybrid Homo sapiens
15 SALL1 6299
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
16 RIC8A 60626
Two-hybrid Homo sapiens
17 NBN 4683
Two-hybrid Homo sapiens
18 SH3GL3  
Two-hybrid Homo sapiens
19 TNKS2 80351
Invitro Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
20 TERF1 7013
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
21 GIT1 28964
Two-hybrid Homo sapiens
22 NME1 4830
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
23 TINF2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TERF1 is involved
PathwayEvidenceSource
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
Meiotic synapsis TAS Reactome
Packaging Of Telomere Ends TAS Reactome





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