Gene description for TBPL1
Gene name TBP-like 1
Gene symbol TBPL1
Other names/aliases MGC:8389
MGC:9620
STUD
TLF
TLP
TRF2
Species Homo sapiens
 Database cross references - TBPL1
ExoCarta ExoCarta_9519
Vesiclepedia VP_9519
Entrez Gene 9519
HGNC 11589
MIM 605521
UniProt P62380  
 TBPL1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TBPL1
Molecular Function
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II general transcription initiation factor activity GO:0016251 IDA
    general transcription initiation factor activity GO:0140223 IBA
Biological Process
    acrosome assembly GO:0001675 IEA
    dTTP biosynthetic process GO:0006235 IEA
    DNA-templated transcription initiation GO:0006352 IBA
    transcription by RNA polymerase II GO:0006366 TAS
    spermatid nucleus differentiation GO:0007289 IEA
Subcellular Localization
    male germ cell nucleus GO:0001673 IEA
    transcription factor TFIIA complex GO:0005672 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified TBPL1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TBPL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF2A1 2957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 FTL 2512
Affinity Capture-MS Homo sapiens
3 TAF6 6878
Affinity Capture-MS Homo sapiens
4 RAB35 11021
Two-hybrid Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 TERF2  
Affinity Capture-MS Homo sapiens
7 NDUFA6  
Two-hybrid Homo sapiens
8 TP53 7157
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 PRNP 5621
Reconstituted Complex Homo sapiens
10 TAF1L  
Affinity Capture-MS Homo sapiens
11 RPL10 6134
Two-hybrid Homo sapiens
12 NR3C1 2908
Proximity Label-MS Homo sapiens
13 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
14 FUS 2521
Affinity Capture-MS Homo sapiens
15 TAF1  
Affinity Capture-MS Homo sapiens
16 GTF2B 2959
Reconstituted Complex Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
18 TAF5  
Affinity Capture-MS Homo sapiens
19 TBP  
Affinity Capture-MS Homo sapiens
20 TERF1 7013
Affinity Capture-MS Homo sapiens
21 PMVK 10654
Affinity Capture-MS Homo sapiens
22 GTF2A2 2958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TGM1 7051
Affinity Capture-MS Homo sapiens
24 HSPA9 3313
Affinity Capture-MS Homo sapiens
25 TBPL2  
Affinity Capture-MS Homo sapiens
26 TAF4 6874
Affinity Capture-MS Homo sapiens
27 TNNT1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TBPL1 is involved
No pathways found





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