Gene description for TAF6
Gene name TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Gene symbol TAF6
Other names/aliases MGC:8964
TAF(II)70
TAF(II)80
TAF2E
TAFII-70
TAFII-80
TAFII70
TAFII80
TAFII85
Species Homo sapiens
 Database cross references - TAF6
ExoCarta ExoCarta_6878
Vesiclepedia VP_6878
Entrez Gene 6878
HGNC 11540
MIM 602955
UniProt P49848  
 TAF6 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TAF6
Molecular Function
    DNA binding GO:0003677 IDA
    transcription coactivator activity GO:0003713 IBA
    protein binding GO:0005515 IPI
    RNA polymerase II general transcription initiation factor activity GO:0016251 IBA
    RNA polymerase II general transcription initiation factor activity GO:0016251 IDA
    RNA polymerase II general transcription initiation factor activity GO:0016251 IDA
    aryl hydrocarbon receptor binding GO:0017162 IPI
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    regulation of DNA repair GO:0006282 NAS
    DNA-templated transcription initiation GO:0006352 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    transcription by RNA polymerase II GO:0006366 NAS
    transcription initiation at RNA polymerase II promoter GO:0006367 IDA
    apoptotic process GO:0006915 IEA
    negative regulation of cell population proliferation GO:0008285 IDA
    mRNA transcription by RNA polymerase II GO:0042789 IDA
    positive regulation of apoptotic process GO:0043065 IDA
    negative regulation of cell cycle GO:0045786 IDA
    positive regulation of DNA-templated transcription GO:0045893 NAS
    RNA polymerase II preinitiation complex assembly GO:0051123 IBA
    RNA polymerase II preinitiation complex assembly GO:0051123 IPI
    RNA polymerase II preinitiation complex assembly GO:0051123 ISS
    positive regulation of transcription initiation by RNA polymerase II GO:0060261 IDA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IDA
Subcellular Localization
    SAGA complex GO:0000124 IEA
    nucleus GO:0005634 EXP
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription factor TFIID complex GO:0005669 IBA
    transcription factor TFIID complex GO:0005669 IDA
    transcription factor TFIID complex GO:0005669 IPI
    transcription factor TFIID complex GO:0005669 ISS
    cytosol GO:0005829 IDA
    protein-containing complex GO:0032991 IMP
    transcription factor TFTC complex GO:0033276 IDA
    transcription factor TFTC complex GO:0033276 NAS
    SLIK (SAGA-like) complex GO:0046695 IEA
    MLL1 complex GO:0071339 IDA
 Experiment description of studies that identified TAF6 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TAF6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP6V1B2 526
Co-fractionation Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 MCM3 4172
Co-fractionation Homo sapiens
4 GTF2F1 2962
Co-fractionation Homo sapiens
5 CDC26 246184
Co-fractionation Homo sapiens
6 HDAC2 3066
Affinity Capture-Western Homo sapiens
7 ELF1 1997
Proximity Label-MS Homo sapiens
8 BRDT  
Affinity Capture-MS Homo sapiens
9 FEV  
Proximity Label-MS Homo sapiens
10 TRRAP 8295
Affinity Capture-Western Homo sapiens
11 TTC4  
Co-fractionation Homo sapiens
12 MARCKSL1 65108
Co-fractionation Homo sapiens
13 TPD52L2 7165
Co-fractionation Homo sapiens
14 TAF1L  
Co-fractionation Homo sapiens
15 TPM2 7169
Co-fractionation Homo sapiens
16 MCM7 4176
Co-fractionation Homo sapiens
17 NFYC 4802
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
18 ACTC1 70
Proximity Label-MS Homo sapiens
19 PRPF4 9128
Co-fractionation Homo sapiens
20 TAF3 83860
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
21 BRD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CSE1L 1434
Co-fractionation Homo sapiens
23 SAP30 8819
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
24 TAF7  
Co-fractionation Homo sapiens
25 TAF1  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
26 TAF8  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
28 TAF5  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
29 MYOD1  
Proximity Label-MS Homo sapiens
30 TCEA1 6917
Co-fractionation Homo sapiens
31 NCOR1  
Reconstituted Complex Homo sapiens
32 RNPS1 10921
Affinity Capture-MS Homo sapiens
33 TAF9 6880
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
34 KLF8  
Proximity Label-MS Homo sapiens
35 PAX6  
Proximity Label-MS Homo sapiens
36 ALL1  
Affinity Capture-Western Homo sapiens
37 GNS 2799
Co-fractionation Homo sapiens
38 SPAG9 9043
Co-fractionation Homo sapiens
39 IQGAP1 8826
Co-fractionation Homo sapiens
40 KLF15  
Proximity Label-MS Homo sapiens
41 BOD1L1 259282
Affinity Capture-MS Homo sapiens
42 BRD4 23476
Affinity Capture-MS Homo sapiens
43 EEF1G 1937
Co-fractionation Homo sapiens
44 ATG16L1 55054
Affinity Capture-MS Homo sapiens
45 SETD1A 9739
Co-fractionation Homo sapiens
46 NMT1 4836
Co-fractionation Homo sapiens
47 CHD3 1107
Affinity Capture-Western Homo sapiens
48 SMARCB1 6598
Affinity Capture-Western Homo sapiens
49 SMARCA2 6595
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 MTA2 9219
Co-fractionation Homo sapiens
51 USP37  
Proximity Label-MS Homo sapiens
52 MYL6 4637
Co-fractionation Homo sapiens
53 KLF16  
Proximity Label-MS Homo sapiens
54 BANP  
Two-hybrid Homo sapiens
55 RBBP7 5931
Affinity Capture-Western Homo sapiens
56 MAPK3 5595
Affinity Capture-MS Homo sapiens
57 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
58 PSMD4 5710
Co-fractionation Homo sapiens
59 HMGCS1 3157
Co-fractionation Homo sapiens
60 TAF10 6881
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
61 SPATA25  
Affinity Capture-MS Homo sapiens
62 SUPT5H 6829
Co-fractionation Homo sapiens
63 IKZF3  
Affinity Capture-MS Homo sapiens
64 NFIX 4784
Proximity Label-MS Homo sapiens
65 COPB1 1315
Co-fractionation Homo sapiens
66 TAF9B  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
67 SREBF2 6721
Negative Genetic Homo sapiens
68 RAN 5901
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
69 TAF12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
70 ACTL6A 86
Co-fractionation Homo sapiens
71 PPP1R21 129285
Affinity Capture-MS Homo sapiens
72 XPOT 11260
Co-fractionation Homo sapiens
73 RFC4 5984
Affinity Capture-MS Homo sapiens
74 MBD3 53615
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
75 EN1  
Proximity Label-MS Homo sapiens
76 MYL12A 10627
Co-fractionation Homo sapiens
77 KLF12  
Proximity Label-MS Homo sapiens
78 CEBPA  
Proximity Label-MS Homo sapiens
79 SETD7 80854
Affinity Capture-Western Homo sapiens
80 TAF13  
Affinity Capture-MS Homo sapiens
81 SP100 6672
Affinity Capture-MS Homo sapiens
82 SMARCC2 6601
Affinity Capture-Western Homo sapiens
83 GTF2A1 2957
Affinity Capture-MS Homo sapiens
84 ACTN1 87
Co-fractionation Homo sapiens
85 NTRK1 4914
Affinity Capture-MS Homo sapiens
86 CCNA2 890
Affinity Capture-MS Homo sapiens
87 MYL3 4634
Cross-Linking-MS (XL-MS) Homo sapiens
88 KMT2A  
Co-fractionation Homo sapiens
89 AHCYL1 10768
Co-fractionation Homo sapiens
90 TIPRL 261726
Co-fractionation Homo sapiens
91 SMARCA5 8467
Co-fractionation Homo sapiens
92 ELK3  
Proximity Label-MS Homo sapiens
93 HCFC1 3054
Co-fractionation Homo sapiens
94 PHIP 55023
Affinity Capture-MS Homo sapiens
95 TUBB4B 10383
Co-fractionation Homo sapiens
96 EGFR 1956
Negative Genetic Homo sapiens
97 YY1 7528
Proximity Label-MS Homo sapiens
98 ERCC1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
99 FTH1 2495
Co-fractionation Homo sapiens
100 IKZF1  
Affinity Capture-MS Homo sapiens
101 RBBP4 5928
Affinity Capture-Western Homo sapiens
102 HIST3H3 8290
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
103 TBPL1 9519
Affinity Capture-MS Homo sapiens
104 PRKCI 5584
Co-fractionation Homo sapiens
105 HNF4A  
Proximity Label-MS Homo sapiens
106 RPL29 6159
Co-fractionation Homo sapiens
107 NAPA 8775
Co-fractionation Homo sapiens
108 DKC1 1736
Co-fractionation Homo sapiens
109 RPA3 6119
Proximity Label-MS Homo sapiens
110 AHR 196
Reconstituted Complex Homo sapiens
111 DLST 1743
Co-fractionation Homo sapiens
112 WDR5 11091
Co-fractionation Homo sapiens
113 TXNL1 9352
Co-fractionation Homo sapiens
114 ETS1  
Proximity Label-MS Homo sapiens
115 HSPA4 3308
Co-fractionation Homo sapiens
116 SOX5 6660
Affinity Capture-MS Homo sapiens
117 RABGGTB 5876
Co-fractionation Homo sapiens
118 NFYA 4800
Reconstituted Complex Homo sapiens
119 SNRPD3 6634
Co-fractionation Homo sapiens
120 CHM 1121
Co-fractionation Homo sapiens
121 BRD3 8019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 TAF4 6874
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
123 MGEA5 10724
Co-fractionation Homo sapiens
124 ELF4 2000
Proximity Label-MS Homo sapiens
125 TPM3 7170
Co-fractionation Homo sapiens
126 SART1 9092
Co-fractionation Homo sapiens
127 RELA 5970
Reconstituted Complex Homo sapiens
128 PRMT3 10196
Co-fractionation Homo sapiens
129 MAX  
Co-fractionation Homo sapiens
130 KAT2A  
Affinity Capture-MS Homo sapiens
131 TP53 7157
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
132 SIN3A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
133 TAF7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 TBP  
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-RNA Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
135 PPP2R2A 5520
Co-fractionation Homo sapiens
136 LONP1 9361
Co-fractionation Homo sapiens
137 SMARCC1 6599
Affinity Capture-Western Homo sapiens
138 PIH1D2  
Two-hybrid Homo sapiens
139 HSPB1 3315
Co-fractionation Homo sapiens
140 HDAC1 3065
Affinity Capture-Western Homo sapiens
141 CHD4 1108
Affinity Capture-MS Homo sapiens
142 TAF2  
Co-fractionation Homo sapiens
143 GNB1 2782
Co-fractionation Homo sapiens
144 MAGEA9  
Affinity Capture-MS Homo sapiens
145 MKI67  
Affinity Capture-MS Homo sapiens
146 Samm50  
Affinity Capture-MS Mus musculus
147 KDM1A 23028
Co-fractionation Homo sapiens
148 NFYB  
Reconstituted Complex Homo sapiens
149 PSMA5 5686
Co-fractionation Homo sapiens
150 Dctn3  
Affinity Capture-MS Mus musculus
151 CAD 790
Co-fractionation Homo sapiens
152 YBX3 8531
Co-fractionation Homo sapiens
153 ZCCHC10  
Affinity Capture-MS Homo sapiens
154 CIT 11113
Affinity Capture-MS Homo sapiens
155 GTF2E1 2960
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
156 STAT1 6772
Co-fractionation Homo sapiens
157 ELF2  
Proximity Label-MS Homo sapiens
158 KRAS 3845
Negative Genetic Homo sapiens
159 Ufl1  
Affinity Capture-MS Mus musculus
160 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
161 USF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 VIM 7431
Co-fractionation Homo sapiens
163 PURA 5813
Co-fractionation Homo sapiens
164 NR1D2  
Reconstituted Complex Homo sapiens
165 EP300 2033
Affinity Capture-MS Homo sapiens
166 NHLH1  
Proximity Label-MS Homo sapiens
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