Gene description for NFIX
Gene name nuclear factor I/X (CCAAT-binding transcription factor)
Gene symbol NFIX
Other names/aliases MRSHSS
NF1A
SOTOS2
Species Homo sapiens
 Database cross references - NFIX
ExoCarta ExoCarta_4784
Vesiclepedia VP_4784
Entrez Gene 4784
HGNC 7788
MIM 164005
UniProt Q14938  
 NFIX identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for NFIX
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription factor activity GO:0003700 TAS
    protein binding GO:0005515 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    DNA replication GO:0006260 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    transcription by RNA polymerase II GO:0006366 TAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified NFIX in exosomes
1
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for NFIX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MORC2  
Proximity Label-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 MCRS1  
Proximity Label-MS Homo sapiens
4 SMC3 9126
Proximity Label-MS Homo sapiens
5 FOXA1  
Affinity Capture-MS Homo sapiens
6 ISG15 9636
Affinity Capture-MS Homo sapiens
7 ZFHX4  
Proximity Label-MS Homo sapiens
8 KMT2C 58508
Proximity Label-MS Homo sapiens
9 ELF1 1997
Proximity Label-MS Homo sapiens
10 ZBTB40  
Proximity Label-MS Homo sapiens
11 PAXIP1  
Proximity Label-MS Homo sapiens
12 NFIB  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TRRAP 8295
Proximity Label-MS Homo sapiens
14 ARID3A  
Proximity Label-MS Homo sapiens
15 SKI 6497
Reconstituted Complex Homo sapiens
Phenotypic Enhancement Homo sapiens
16 AES 166
Proximity Label-MS Homo sapiens
17 POGZ 23126
Proximity Label-MS Homo sapiens
18 TLX3  
Reconstituted Complex Homo sapiens
19 ZNF608  
Proximity Label-MS Homo sapiens
20 BRD7  
Proximity Label-MS Homo sapiens
21 PAX2  
Reconstituted Complex Homo sapiens
22 SMARCE1 6605
Proximity Label-MS Homo sapiens
23 TCF7L2  
Proximity Label-MS Homo sapiens
24 ZZZ3  
Proximity Label-MS Homo sapiens
25 BRD2  
Proximity Label-MS Homo sapiens
26 KDM6A  
Proximity Label-MS Homo sapiens
27 PIR 8544
Two-hybrid Homo sapiens
28 ARID3B  
Proximity Label-MS Homo sapiens
29 RREB1 6239
Proximity Label-MS Homo sapiens
30 SOX9  
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
31 SOX10  
Reconstituted Complex Homo sapiens
32 SOX2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
33 TAF5  
Proximity Label-MS Homo sapiens
34 PAX6  
Reconstituted Complex Homo sapiens
35 SATB2  
Proximity Label-MS Homo sapiens
36 QSER1  
Proximity Label-MS Homo sapiens
37 SOX15  
Reconstituted Complex Homo sapiens
38 IRF2BP1 26145
Proximity Label-MS Homo sapiens
39 MBIP  
Proximity Label-MS Homo sapiens
40 NCOR1  
Proximity Label-MS Homo sapiens
41 C11orf30  
Proximity Label-MS Homo sapiens
42 VPS72  
Proximity Label-MS Homo sapiens
43 GSE1 23199
Proximity Label-MS Homo sapiens
44 ZFHX3  
Proximity Label-MS Homo sapiens
45 RFXANK  
Proximity Label-MS Homo sapiens
46 NR2C2  
Proximity Label-MS Homo sapiens
47 E2F6 1876
Proximity Label-MS Homo sapiens
48 ING3  
Proximity Label-MS Homo sapiens
49 FOXN1  
Affinity Capture-MS Homo sapiens
50 ARID4B  
Proximity Label-MS Homo sapiens
51 CUX1 1523
Proximity Label-MS Homo sapiens
52 ZSCAN21  
Proximity Label-MS Homo sapiens
53 KMT2D 8085
Proximity Label-MS Homo sapiens
54 C17orf49 124944
Proximity Label-MS Homo sapiens
55 ZNF614 80110
Two-hybrid Homo sapiens
56 BCOR  
Proximity Label-MS Homo sapiens
57 NR2C1  
Proximity Label-MS Homo sapiens
58 WIZ 58525
Proximity Label-MS Homo sapiens
59 SETD1A 9739
Proximity Label-MS Homo sapiens
60 SOX17  
Reconstituted Complex Homo sapiens
61 SMARCA2 6595
Proximity Label-MS Homo sapiens
62 KMT2B  
Proximity Label-MS Homo sapiens
63 RBPJ 3516
Affinity Capture-MS Homo sapiens
64 SMARCD2 6603
Proximity Label-MS Homo sapiens
65 FOXP1 27086
Proximity Label-MS Homo sapiens
66 RB1 5925
Affinity Capture-Western Homo sapiens
67 ZNF217 7764
Proximity Label-MS Homo sapiens
68 RFX5 5993
Proximity Label-MS Homo sapiens
69 RFXAP  
Proximity Label-MS Homo sapiens
70 JMJD6 23210
Two-hybrid Homo sapiens
71 RLF 6018
Proximity Label-MS Homo sapiens
72 PRDM1  
Reconstituted Complex Homo sapiens
73 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
74 NFRKB  
Proximity Label-MS Homo sapiens
75 ZNF281  
Proximity Label-MS Homo sapiens
76 RFX1  
Affinity Capture-Western Homo sapiens
77 NCOR2  
Proximity Label-MS Homo sapiens
78 HIVEP1 3096
Proximity Label-MS Homo sapiens
79 TBR1  
Reconstituted Complex Homo sapiens
80 FAM60A  
Proximity Label-MS Homo sapiens
81 NFIX 4784
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
82 TRIM24  
Proximity Label-MS Homo sapiens
83 TFDP1  
Proximity Label-MS Homo sapiens
84 ZEB2  
Proximity Label-MS Homo sapiens
85 NFIA 4774
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 ZHX2  
Proximity Label-MS Homo sapiens
87 PDS5A 23244
Proximity Label-MS Homo sapiens
88 BCL7C  
Proximity Label-MS Homo sapiens
89 TAF12  
Proximity Label-MS Homo sapiens
90 FOXK2  
Proximity Label-MS Homo sapiens
91 BPTF 2186
Proximity Label-MS Homo sapiens
92 ZNF131  
Proximity Label-MS Homo sapiens
93 ZKSCAN4  
Proximity Label-MS Homo sapiens
94 MYBL2 4605
Proximity Label-MS Homo sapiens
95 CIC 23152
Proximity Label-MS Homo sapiens
96 SMC1A 8243
Proximity Label-MS Homo sapiens
97 L3MBTL2  
Proximity Label-MS Homo sapiens
98 RAD21 5885
Proximity Label-MS Homo sapiens
99 ZNF609  
Proximity Label-MS Homo sapiens
100 SMARCC2 6601
Proximity Label-MS Homo sapiens
101 ZMYM4  
Proximity Label-MS Homo sapiens
102 YEATS4  
Proximity Label-MS Homo sapiens
103 ATXN1 6310
Proximity Label-MS Homo sapiens
104 RING1 6015
Proximity Label-MS Homo sapiens
105 ZNF644  
Proximity Label-MS Homo sapiens
106 TLX2  
Reconstituted Complex Homo sapiens
107 DPF2  
Proximity Label-MS Homo sapiens
108 GTF3C3 9330
Proximity Label-MS Homo sapiens
109 KMT2A  
Proximity Label-MS Homo sapiens
110 SOX6  
Reconstituted Complex Homo sapiens
111 SMARCD1 6602
Proximity Label-MS Homo sapiens
112 MGA  
Proximity Label-MS Homo sapiens
113 GTF3C1  
Proximity Label-MS Homo sapiens
114 TLE3  
Proximity Label-MS Homo sapiens
115 PAX8  
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
116 LHX4  
Reconstituted Complex Homo sapiens
117 ZNF143  
Proximity Label-MS Homo sapiens
118 TFAP4 7023
Proximity Label-MS Homo sapiens
119 CSRP2BP  
Proximity Label-MS Homo sapiens
120 DACH1  
Proximity Label-MS Homo sapiens
121 DTX2 113878
Proximity Label-MS Homo sapiens
122 YY1 7528
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
123 KANSL2  
Proximity Label-MS Homo sapiens
124 EP400  
Proximity Label-MS Homo sapiens
125 BAP1 8314
Proximity Label-MS Homo sapiens
126 BRMS1L  
Proximity Label-MS Homo sapiens
127 ELMSAN1  
Proximity Label-MS Homo sapiens
128 ARID1B 57492
Proximity Label-MS Homo sapiens
129 JUN 3725
Affinity Capture-MS Homo sapiens
130 DMAP1 55929
Proximity Label-MS Homo sapiens
131 SRF  
Proximity Label-MS Homo sapiens
132 FOS 2353
Affinity Capture-MS Homo sapiens
133 ZNF521  
Proximity Label-MS Homo sapiens
134 SPEN 23013
Proximity Label-MS Homo sapiens
135 MSANTD2  
Proximity Label-MS Homo sapiens
136 EHMT2 10919
Proximity Label-MS Homo sapiens
137 NIPBL 25836
Proximity Label-MS Homo sapiens
138 TBL1X 6907
Proximity Label-MS Homo sapiens
139 KANSL3  
Proximity Label-MS Homo sapiens
140 PCGF1 84759
Proximity Label-MS Homo sapiens
141 SOX5 6660
Reconstituted Complex Homo sapiens
142 ARID1A 8289
Proximity Label-MS Homo sapiens
143 RBBP5 5929
Proximity Label-MS Homo sapiens
144 ARID2  
Proximity Label-MS Homo sapiens
145 KDM2B 84678
Proximity Label-MS Homo sapiens
146 TAF4 6874
Proximity Label-MS Homo sapiens
147 GLTSCR1 29998
Proximity Label-MS Homo sapiens
148 KAT2A  
Proximity Label-MS Homo sapiens
149 GATAD1  
Proximity Label-MS Homo sapiens
150 TAF6 6878
Proximity Label-MS Homo sapiens
151 FOXC1  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
152 TRPS1  
Proximity Label-MS Homo sapiens
153 SAP130  
Proximity Label-MS Homo sapiens
154 PHF12  
Proximity Label-MS Homo sapiens
155 DPF1  
Proximity Label-MS Homo sapiens
156 ZEB1  
Proximity Label-MS Homo sapiens
157 ATXN1L  
Proximity Label-MS Homo sapiens
158 ZNF746  
Proximity Label-MS Homo sapiens
159 SMARCC1 6599
Proximity Label-MS Homo sapiens
160 IRF2BP2  
Proximity Label-MS Homo sapiens
161 TLE1 7088
Proximity Label-MS Homo sapiens
162 SIX4  
Proximity Label-MS Homo sapiens
163 ZNF536  
Proximity Label-MS Homo sapiens
164 PBRM1 55193
Proximity Label-MS Homo sapiens
165 SMAD4  
Affinity Capture-MS Homo sapiens
166 HDAC1 3065
Affinity Capture-Western Homo sapiens
167 ZBTB10 65986
Proximity Label-MS Homo sapiens
168 SALL1 6299
Proximity Label-MS Homo sapiens
169 PAX9  
Proximity Label-MS Homo sapiens
170 CREB1  
Affinity Capture-MS Homo sapiens
171 PRR12 57479
Proximity Label-MS Homo sapiens
172 SSBP1 6742
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 POU2F1 5451
Proximity Label-MS Homo sapiens
174 PAX7  
Reconstituted Complex Homo sapiens
175 ZNF148  
Proximity Label-MS Homo sapiens
176 L3MBTL3  
Proximity Label-MS Homo sapiens
177 GTF3C2  
Proximity Label-MS Homo sapiens
178 QRICH1  
Two-hybrid Homo sapiens
179 SRCAP  
Proximity Label-MS Homo sapiens
180 RYBP  
Proximity Label-MS Homo sapiens
181 ASH2L 9070
Proximity Label-MS Homo sapiens
182 CXXC1  
Proximity Label-MS Homo sapiens
183 LIN54  
Proximity Label-MS Homo sapiens
184 ZNF512  
Proximity Label-MS Homo sapiens
185 EHMT1  
Proximity Label-MS Homo sapiens
186 ELF2  
Proximity Label-MS Homo sapiens
187 NFIC 4782
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 AR 367
Proximity Label-MS Homo sapiens
189 SMARCD3  
Proximity Label-MS Homo sapiens
190 GABPA 2551
Proximity Label-MS Homo sapiens
191 SP7  
Reconstituted Complex Homo sapiens
192 BCL7A  
Proximity Label-MS Homo sapiens
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