Gene description for CIC
Gene name capicua transcriptional repressor
Gene symbol CIC
Other names/aliases -
Species Homo sapiens
 Database cross references - CIC
ExoCarta ExoCarta_23152
Entrez Gene 23152
HGNC 14214
MIM 612082
UniProt Q96RK0  
 CIC identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CIC
Molecular Function
    chromatin binding GO:0003682 IEA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    lung alveolus development GO:0048286 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
 Experiment description of studies that identified CIC in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CIC
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CIC is involved
No pathways found





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