Gene description for TRIM22
Gene name tripartite motif containing 22
Gene symbol TRIM22
Other names/aliases GPSTAF50
RNF94
STAF50
Species Homo sapiens
 Database cross references - TRIM22
ExoCarta ExoCarta_10346
Vesiclepedia VP_10346
Entrez Gene 10346
HGNC 16379
MIM 606559
UniProt Q8IYM9  
 TRIM22 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TRIM22
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    transcription corepressor activity GO:0003714 TAS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IPI
    protein-macromolecule adaptor activity GO:0030674 IPI
    identical protein binding GO:0042802 IPI
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    positive regulation of defense response to virus by host GO:0002230 IDA
    regulation of DNA-templated transcription GO:0006355 TAS
    immune response GO:0006955 TAS
    response to virus GO:0009615 TAS
    regulation of gene expression GO:0010468 IBA
    positive regulation of autophagy GO:0010508 IBA
    positive regulation of autophagy GO:0010508 IMP
    regulation of protein localization GO:0032880 IBA
    regulation of protein localization GO:0032880 IMP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    innate immune response GO:0045087 IBA
    negative regulation of DNA-templated transcription GO:0045892 IEA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    defense response to virus GO:0051607 IEA
    protein K63-linked ubiquitination GO:0070534 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 TAS
    Cajal body GO:0015030 IEA
    nuclear body GO:0016604 IDA
    nuclear speck GO:0016607 IEA
 Experiment description of studies that identified TRIM22 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRIM22
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHUK 1147
Affinity Capture-Western Homo sapiens
2 CIC 23152
Two-hybrid Homo sapiens
3 LGALS3 3958
Reconstituted Complex Homo sapiens
4 PML 5371
Affinity Capture-MS Homo sapiens
5 TAF7  
Two-hybrid Homo sapiens
6 LGALS8 3964
Reconstituted Complex Homo sapiens
7 PLEKHF2 79666
Two-hybrid Homo sapiens
8 USP7 7874
Two-hybrid Homo sapiens
9 ZZZ3  
Two-hybrid Homo sapiens
10 KAT2A  
Affinity Capture-Western Homo sapiens
11 TAB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 EIF4E 1977
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 RERE 473
Two-hybrid Homo sapiens
14 TRIM22 10346
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
15 CREB1  
Two-hybrid Homo sapiens
16 CASK 8573
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRIM22 is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system TAS Reactome
Immune System TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome





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