Gene description for ELF4
Gene name E74-like factor 4 (ets domain transcription factor)
Gene symbol ELF4
Other names/aliases ELFR
MEF
Species Homo sapiens
 Database cross references - ELF4
ExoCarta ExoCarta_2000
Vesiclepedia VP_2000
Entrez Gene 2000
HGNC 3319
MIM 300775
UniProt Q99607  
 ELF4 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ELF4
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    protein binding GO:0005515 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    natural killer cell proliferation GO:0001787 ISS
    NK T cell proliferation GO:0001866 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    cell differentiation GO:0030154 IBA
    negative regulation of interleukin-1 beta production GO:0032691 IMP
    negative regulation of interleukin-6 production GO:0032715 IMP
    negative regulation of tumor necrosis factor production GO:0032720 IMP
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    negative regulation of inflammatory response GO:0050728 IMP
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nuclear body GO:0016604 IDA
    PML body GO:0016605 IDA
 Experiment description of studies that identified ELF4 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ELF4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCRS1  
Proximity Label-MS Homo sapiens
2 ZMYM4  
Proximity Label-MS Homo sapiens
3 MBTD1  
Proximity Label-MS Homo sapiens
4 TRRAP 8295
Proximity Label-MS Homo sapiens
5 POGZ 23126
Proximity Label-MS Homo sapiens
6 TAF3 83860
Proximity Label-MS Homo sapiens
7 TRIM33 51592
Proximity Label-MS Homo sapiens
8 ZZZ3  
Proximity Label-MS Homo sapiens
9 KDM6A  
Proximity Label-MS Homo sapiens
10 KANSL3  
Proximity Label-MS Homo sapiens
11 SMARCD2 6603
Proximity Label-MS Homo sapiens
12 ASXL1  
Proximity Label-MS Homo sapiens
13 TAF5  
Proximity Label-MS Homo sapiens
14 ZNF687  
Proximity Label-MS Homo sapiens
15 SRCAP  
Proximity Label-MS Homo sapiens
16 C11orf30  
Proximity Label-MS Homo sapiens
17 VPS72  
Proximity Label-MS Homo sapiens
18 CCAR2 57805
Affinity Capture-MS Homo sapiens
19 PSMB5 5693
Affinity Capture-MS Homo sapiens
20 E2F6 1876
Proximity Label-MS Homo sapiens
21 ZNF148  
Proximity Label-MS Homo sapiens
22 ARID4B  
Proximity Label-MS Homo sapiens
23 NPM1 4869
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
24 KMT2D 8085
Proximity Label-MS Homo sapiens
25 UCHL5 51377
Proximity Label-MS Homo sapiens
26 ZNF644  
Proximity Label-MS Homo sapiens
27 SETD1A 9739
Proximity Label-MS Homo sapiens
28 SMARCA2 6595
Proximity Label-MS Homo sapiens
29 TAF5L  
Proximity Label-MS Homo sapiens
30 KANSL1  
Proximity Label-MS Homo sapiens
31 RUNX1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 CXXC1  
Proximity Label-MS Homo sapiens
33 PHF10  
Proximity Label-MS Homo sapiens
34 ATF7IP 55729
Proximity Label-MS Homo sapiens
35 ASH2L 9070
Proximity Label-MS Homo sapiens
36 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
37 NFRKB  
Proximity Label-MS Homo sapiens
38 SUPT7L  
Proximity Label-MS Homo sapiens
39 FAM60A  
Proximity Label-MS Homo sapiens
40 LRIF1  
Proximity Label-MS Homo sapiens
41 TRIM24  
Proximity Label-MS Homo sapiens
42 CPVL 54504
Proximity Label-MS Homo sapiens
43 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 ZHX2  
Proximity Label-MS Homo sapiens
45 TAF12  
Proximity Label-MS Homo sapiens
46 KDM5B  
Affinity Capture-MS Homo sapiens
47 HIRA  
Proximity Label-MS Homo sapiens
48 BPTF 2186
Proximity Label-MS Homo sapiens
49 MYBL2 4605
Proximity Label-MS Homo sapiens
50 CIC 23152
Proximity Label-MS Homo sapiens
51 PML 5371
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 PHF12  
Proximity Label-MS Homo sapiens
53 FLOT2 2319
Affinity Capture-MS Homo sapiens
54 SP2  
Proximity Label-MS Homo sapiens
55 CASP4  
Two-hybrid Homo sapiens
56 ATXN1 6310
Proximity Label-MS Homo sapiens
57 BRD7  
Proximity Label-MS Homo sapiens
58 ASXL2  
Proximity Label-MS Homo sapiens
59 SMCHD1 23347
Proximity Label-MS Homo sapiens
60 ZHX1  
Proximity Label-MS Homo sapiens
61 SMARCD1 6602
Proximity Label-MS Homo sapiens
62 SEC13 6396
Affinity Capture-MS Homo sapiens
63 MGA  
Proximity Label-MS Homo sapiens
64 BRD8 10902
Proximity Label-MS Homo sapiens
65 SKP2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
66 YY1 7528
Proximity Label-MS Homo sapiens
67 NUP43 348995
Proximity Label-MS Homo sapiens
68 KANSL2  
Proximity Label-MS Homo sapiens
69 EP400  
Proximity Label-MS Homo sapiens
70 BAP1 8314
Proximity Label-MS Homo sapiens
71 MORF4L1  
Proximity Label-MS Homo sapiens
72 NT5C2 22978
Affinity Capture-MS Homo sapiens
73 ACTR6  
Proximity Label-MS Homo sapiens
74 DMAP1 55929
Proximity Label-MS Homo sapiens
75 ACTR5 79913
Proximity Label-MS Homo sapiens
76 TADA2A  
Proximity Label-MS Homo sapiens
77 SET 6418
Two-hybrid Homo sapiens
78 INO80  
Proximity Label-MS Homo sapiens
79 EHMT2 10919
Proximity Label-MS Homo sapiens
80 KAT5  
Proximity Label-MS Homo sapiens
81 ACTR8 93973
Proximity Label-MS Homo sapiens
82 CCDC101  
Proximity Label-MS Homo sapiens
83 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
84 SENP5  
Proximity Label-MS Homo sapiens
85 RBBP5 5929
Proximity Label-MS Homo sapiens
86 KAT2A  
Proximity Label-MS Homo sapiens
87 FOXK1 221937
Proximity Label-MS Homo sapiens
88 TAF4 6874
Proximity Label-MS Homo sapiens
89 FLOT1 10211
Affinity Capture-MS Homo sapiens
90 TAF6 6878
Proximity Label-MS Homo sapiens
91 SLC25A11 8402
Affinity Capture-MS Homo sapiens
92 KAT8  
Proximity Label-MS Homo sapiens
93 ARID2  
Proximity Label-MS Homo sapiens
94 SUPT20H 55578
Proximity Label-MS Homo sapiens
95 L3MBTL2  
Proximity Label-MS Homo sapiens
96 KMT2B  
Proximity Label-MS Homo sapiens
97 KAT2B  
Proximity Label-MS Homo sapiens
98 PBRM1 55193
Proximity Label-MS Homo sapiens
99 EPC1  
Proximity Label-MS Homo sapiens
100 TAF2  
Proximity Label-MS Homo sapiens
101 INO80C  
Proximity Label-MS Homo sapiens
102 PCGF6  
Proximity Label-MS Homo sapiens
103 LIN54  
Proximity Label-MS Homo sapiens
104 ELF2  
Proximity Label-MS Homo sapiens
105 KDM2B 84678
Proximity Label-MS Homo sapiens
106 GATAD1  
Proximity Label-MS Homo sapiens
107 GABPA 2551
Proximity Label-MS Homo sapiens
108 BCL7A  
Proximity Label-MS Homo sapiens
109 EPC2  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ELF4 is involved
No pathways found





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