Gene description for ELF4
Gene name E74-like factor 4 (ets domain transcription factor)
Gene symbol ELF4
Other names/aliases ELFR
Species Homo sapiens
 Database cross references - ELF4
ExoCarta ExoCarta_2000
Entrez Gene 2000
HGNC 3319
MIM 300775
UniProt Q99607  
 ELF4 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ELF4
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
Biological Process
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    NK T cell proliferation GO:0001866 ISS
    cell differentiation GO:0030154 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    transcription, DNA-templated GO:0006351 IEA
    natural killer cell proliferation GO:0001787 ISS
Subcellular Localization
    PML body GO:0016605 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified ELF4 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ELF4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RUNX1  
Invitro Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which ELF4 is involved
No pathways found

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