Gene description for GABPA
Gene name GA binding protein transcription factor, alpha subunit 60kDa
Gene symbol GABPA
Other names/aliases E4TF1-60
E4TF1A
NFT2
NRF2
NRF2A
RCH04A07
Species Homo sapiens
 Database cross references - GABPA
ExoCarta ExoCarta_2551
Entrez Gene 2551
HGNC 4071
MIM 600609
UniProt Q06546  
 GABPA identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for GABPA
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 IDA
    DNA binding GO:0003677 TAS
    protein binding GO:0005515 IPI
    transcription regulatory region DNA binding GO:0044212 IDA
    chromatin binding GO:0003682 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    transcription coactivator activity GO:0003713 TAS
    protein heterodimerization activity GO:0046982 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    in utero embryonic development GO:0001701 IEA
    organelle organization GO:0006996 TAS
    cell differentiation GO:0030154 IBA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    transcription from RNA polymerase II promoter GO:0006366 TAS
    mitochondrion organization GO:0007005 TAS
    negative regulation of megakaryocyte differentiation GO:0045653 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nuclear chromatin GO:0000790 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified GABPA in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GABPA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HCFC1 3054
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 SP1  
Invitro Homo sapiens
3 SP3  
Invivo Homo sapiens
4 ATF1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which GABPA is involved
PathwayEvidenceSource
Transcriptional activation of mitochondrial biogenesis TAS Reactome





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