Gene description for RAB3GAP2
Gene name RAB3 GTPase activating protein subunit 2 (non-catalytic)
Gene symbol RAB3GAP2
Other names/aliases RAB3-GAP150
RAB3GAP150
SPG69
WARBM2
p150
Species Homo sapiens
 Database cross references - RAB3GAP2
ExoCarta ExoCarta_25782
Entrez Gene 25782
HGNC 17168
MIM 609275
UniProt Q9H2M9  
 RAB3GAP2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for RAB3GAP2
Molecular Function
    protein heterodimerization activity GO:0046982 ISS
    Rab guanyl-nucleotide exchange factor activity GO:0017112 IMP
    enzyme activator activity GO:0008047 TAS
    enzyme regulator activity GO:0030234 ISS
    Rab GTPase binding GO:0017137 IPI
    GTPase activator activity GO:0005096 IEA
Biological Process
    establishment of protein localization to endoplasmic reticulum membrane GO:0097051 IMP
    positive regulation of endoplasmic reticulum tubular network organization GO:1903373 IMP
    positive regulation of catalytic activity GO:0043085 TAS
    intracellular protein transport GO:0006886 TAS
    positive regulation of GTPase activity GO:0043547 TAS
    regulation of GTPase activity GO:0043087 ISS
Subcellular Localization
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 IDA
    protein complex GO:0043234 IDA
 Experiment description of studies that identified RAB3GAP2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for RAB3GAP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTP4A3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RAB3GAP2 is involved
No pathways found





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