Gene description for EMD
Gene name emerin
Gene symbol EMD
Other names/aliases EDMD
LEMD5
STA
Species Homo sapiens
 Database cross references - EMD
ExoCarta ExoCarta_2010
Entrez Gene 2010
HGNC 3331
MIM 300384
UniProt P50402  
 EMD identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for EMD
Molecular Function
    protein binding GO:0005515 IPI
    beta-tubulin binding GO:0048487 IDA
    actin binding GO:0003779 IDA
Biological Process
    positive regulation of protein export from nucleus GO:0046827 IMP
    mitotic nuclear envelope reassembly GO:0007084 TAS
    cellular response to growth factor stimulus GO:0071363 IMP
    skeletal muscle cell differentiation GO:0035914 IEA
    mitotic nuclear envelope disassembly GO:0007077 TAS
    regulation of canonical Wnt signaling pathway GO:0060828 IMP
    muscle contraction GO:0006936 TAS
    negative regulation of fibroblast proliferation GO:0048147 IMP
    muscle organ development GO:0007517 TAS
    mitotic cell cycle GO:0000278 TAS
    negative regulation of catenin import into nucleus GO:0035414 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    nuclear membrane GO:0031965 IDA
    integral component of membrane GO:0016021 IEA
    nuclear envelope GO:0005635 TAS
    membrane GO:0016020 IDA
    nuclear outer membrane GO:0005640 IDA
    nuclear inner membrane GO:0005637 NAS
    microtubule GO:0005874 IEA
 Experiment description of studies that identified EMD in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EMD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYNE1 23345
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml



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