Gene description for TEX264
Gene name testis expressed 264
Gene symbol TEX264
Other names/aliases ZSIG11
Species Homo sapiens
 Database cross references - TEX264
ExoCarta ExoCarta_51368
Vesiclepedia VP_51368
Entrez Gene 51368
HGNC 30247
UniProt Q9Y6I9  
 TEX264 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TEX264
Molecular Function
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 IDA
Biological Process
    reticulophagy GO:0061709 IBA
    reticulophagy GO:0061709 IDA
    reticulophagy GO:0061709 IMP
    protein-DNA covalent cross-linking repair GO:0106300 IBA
    protein-DNA covalent cross-linking repair GO:0106300 IDA
Subcellular Localization
    autophagosome membrane GO:0000421 IBA
    autophagosome membrane GO:0000421 IDA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    replication fork GO:0005657 IBA
    replication fork GO:0005657 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 IDA
    platelet alpha granule lumen GO:0031093 TAS
 Experiment description of studies that identified TEX264 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TEX264
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HMOX1 3162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LHFPL4  
Two-hybrid Homo sapiens
3 SEC63 11231
Proximity Label-MS Homo sapiens
4 SNX14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SUN1 23353
Affinity Capture-MS Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 CSNK1D 1453
Affinity Capture-MS Homo sapiens
8 DNAJC25 548645
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
9 CEP131 22994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TMEM30A 55754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 C1orf43 25912
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 FFAR2  
Two-hybrid Homo sapiens
13 DIP2A 23181
Affinity Capture-MS Homo sapiens
14 POTEI 653269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EMP1  
Two-hybrid Homo sapiens
16 TM4SF18  
Two-hybrid Homo sapiens
17 DNAJC14  
Proximity Label-MS Homo sapiens
18 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 JPH1 56704
Affinity Capture-MS Homo sapiens
20 CTDNEP1 23399
Affinity Capture-MS Homo sapiens
21 MTCH2 23788
Affinity Capture-MS Homo sapiens
22 BCAP31 10134
Proximity Label-MS Homo sapiens
23 EMD 2010
Proximity Label-MS Homo sapiens
24 ACTBL2 345651
Affinity Capture-MS Homo sapiens
25 TYW1B  
Affinity Capture-MS Homo sapiens
26 SLC34A2 10568
Two-hybrid Homo sapiens
27 ELOVL5 60481
Proximity Label-MS Homo sapiens
28 FKBP8 23770
Proximity Label-MS Homo sapiens
29 SLC10A2  
Two-hybrid Homo sapiens
30 PTPN1 5770
Proximity Label-MS Homo sapiens
31 CXADR 1525
Proximity Label-MS Homo sapiens
32 ERGIC1 57222
Proximity Label-MS Homo sapiens
33 ENTPD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 CREB3L1  
Two-hybrid Homo sapiens
35 MS4A3  
Two-hybrid Homo sapiens
36 MCM10 55388
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PDZD8 118987
Affinity Capture-MS Homo sapiens
38 APEX1 328
Affinity Capture-RNA Homo sapiens
39 EVA1C  
Affinity Capture-MS Homo sapiens
40 FAM209A 200232
Two-hybrid Homo sapiens
41 FOXK1 221937
Affinity Capture-MS Homo sapiens
42 MAPK6  
Affinity Capture-MS Homo sapiens
43 PLEKHG4  
Affinity Capture-MS Homo sapiens
44 GPR42  
Two-hybrid Homo sapiens
45 B3GAT1  
Proximity Label-MS Homo sapiens
46 VANGL2  
Affinity Capture-MS Homo sapiens
47 STAT1 6772
Affinity Capture-MS Homo sapiens
48 TMEM79  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 ATP2A1 487
Proximity Label-MS Homo sapiens
50 GDPD5 81544
Affinity Capture-MS Homo sapiens
51 MINK1 50488
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 LRRC61 65999
Affinity Capture-MS Homo sapiens
53 PDE3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 DHFRL1  
Proximity Label-MS Homo sapiens
55 PLD1 5337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 MAP4K4 9448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 TERF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 OPRM1 4988
Two-hybrid Homo sapiens
59 DNAJC1 64215
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
60 UPK3BL 100134938
Affinity Capture-MS Homo sapiens
61 ABCC10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 CSNK1E 1454
Affinity Capture-MS Homo sapiens
63 PNPLA6 10908
Affinity Capture-MS Homo sapiens
64 ISLR 3671
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CKAP4 10970
Proximity Label-MS Homo sapiens
66 DERL1 79139
Proximity Label-MS Homo sapiens
67 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 OSBPL8 114882
Affinity Capture-MS Homo sapiens
69 TSPAN12  
Two-hybrid Homo sapiens
70 PER1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 PLD2 5338
Affinity Capture-MS Homo sapiens
72 CHEK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 DNAJC16  
Proximity Label-MS Homo sapiens
74 EDA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 RMDN3 55177
Proximity Label-MS Homo sapiens
76 SLC25A46 91137
Proximity Label-MS Homo sapiens
77 CLN6  
Two-hybrid Homo sapiens
View the network image/svg+xml



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