Gene description for HLA-DMB
Gene name major histocompatibility complex, class II, DM beta
Gene symbol HLA-DMB
Other names/aliases D6S221E
RING7
Species Homo sapiens
 Database cross references - HLA-DMB
ExoCarta ExoCarta_3109
Entrez Gene 3109
HGNC 4935
MIM 142856
UniProt P28068  
 HLA-DMB identified in exosomes derived from the following tissue/cell type
B cells 9685355    
 Gene ontology annotations for HLA-DMB
Molecular Function
    MHC class II protein complex binding GO:0023026 IDA
Biological Process
    positive regulation of T cell proliferation GO:0042102 IMP
    positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001190 IMP
    immune response GO:0006955 IEA
    MHC class II protein complex assembly GO:0002399 IMP
    peptide antigen assembly with MHC class II protein complex GO:0002503 IDA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    MHC class II protein complex GO:0042613 IDA
    lysosomal membrane GO:0005765 TAS
    late endosome membrane GO:0031902 IEA
 Experiment description of studies that identified HLA-DMB in exosomes
1
Experiment ID 16
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
MHCII|CD86|LAMP1|LAMP2|CD63|CD81|CD82|ICAM1|TFRC
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 9685355    
Organism Homo sapiens
Experiment description Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.
Authors Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ
Journal name JBC
Publication year 1998
Sample B cells
Sample name RN (HLA-DR15+)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.12-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for HLA-DMB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HLA-DMA  
Invivo Homo sapiens
2 HLA-DOB  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
3 CD63 967
Affinity Capture-Western Homo sapiens
4 CD74 972
Invivo Homo sapiens
5 CD82 3732
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
6 HLA-DRA 3122
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HLA-DMB is involved
PathwayEvidenceSource
MHC class II antigen presentation TAS Reactome





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