Gene description for RAB29
Gene name RAB29, member RAS oncogene family
Gene symbol RAB29
Other names/aliases RAB7L
RAB7L1
Species Homo sapiens
 Database cross references - RAB29
ExoCarta ExoCarta_8934
Vesiclepedia VP_8934
Entrez Gene 8934
HGNC 9789
MIM 603949
UniProt O14966  
 RAB29 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for RAB29
Molecular Function
    GTPase activity GO:0003924 IBA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IDA
    GDP binding GO:0019003 IDA
    kinesin binding GO:0019894 IPI
    small GTPase binding GO:0031267 IDA
    dynein complex binding GO:0070840 IDA
Biological Process
    positive regulation of receptor recycling GO:0001921 IMP
    intracellular protein transport GO:0006886 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IMP
    mitochondrion organization GO:0007005 IMP
    Golgi organization GO:0007030 IMP
    synapse assembly GO:0007416 IMP
    response to bacterium GO:0009617 IDA
    negative regulation of neuron projection development GO:0010977 IDA
    cell differentiation GO:0030154 IEA
    melanosome organization GO:0032438 IBA
    T cell activation GO:0042110 IMP
    retrograde transport, endosome to Golgi GO:0042147 IMP
    modulation by host of viral process GO:0044788 IMP
    positive regulation of T cell receptor signaling pathway GO:0050862 IMP
    protein localization to membrane GO:0072657 IMP
    positive regulation of intracellular protein transport GO:0090316 IMP
    protein localization to ciliary membrane GO:1903441 ISS
    regulation of retrograde transport, endosome to Golgi GO:1905279 IEA
    cellular detoxification GO:1990748 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
    early endosome GO:0005769 IDA
    vacuole GO:0005773 IDA
    Golgi apparatus GO:0005794 IDA
    cis-Golgi network GO:0005801 IDA
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 IDA
    cytosol GO:0005829 IDA
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IEA
    endomembrane system GO:0012505 IBA
    melanosome GO:0042470 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    recycling endosome GO:0055037 IDA
    extracellular exosome GO:0070062 HDA
    intracellular vesicle GO:0097708 IDA
 Experiment description of studies that identified RAB29 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
3
Experiment ID 196
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 197
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RAB29
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 TGOLN2 10618
Co-localization Homo sapiens
3 GOLGA2 2801
Co-localization Homo sapiens
4 STRIP1 85369
Affinity Capture-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 KLRB1  
Affinity Capture-MS Homo sapiens
7 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
8 SLC15A1  
Affinity Capture-MS Homo sapiens
9 APLNR  
Affinity Capture-MS Homo sapiens
10 ITPR2 3709
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 RABGGTA 5875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GPBAR1  
Affinity Capture-MS Homo sapiens
13 ICAM2 3384
Affinity Capture-MS Homo sapiens
14 REL 5966
Two-hybrid Homo sapiens
15 PGRMC1 10857
Affinity Capture-MS Homo sapiens
16 LRRC59 55379
Proximity Label-MS Homo sapiens
17 ITLN1 55600
Affinity Capture-MS Homo sapiens
18 GPR35  
Affinity Capture-MS Homo sapiens
19 PXMP2  
Proximity Label-MS Homo sapiens
20 HSPA4 3308
Affinity Capture-Western Homo sapiens
21 SLC2A4  
Affinity Capture-MS Homo sapiens
22 MFSD4  
Affinity Capture-MS Homo sapiens
23 SLC25A22  
Affinity Capture-MS Homo sapiens
24 ITPR3 3710
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 C11orf49  
Two-hybrid Homo sapiens
26 GAK 2580
Affinity Capture-Western Homo sapiens
27 MTCH2 23788
Proximity Label-MS Homo sapiens
28 PGRMC2 10424
Affinity Capture-MS Homo sapiens
29 SLC2A1 6513
Affinity Capture-MS Homo sapiens
30 PRMT6  
Affinity Capture-MS Homo sapiens
31 FPR1  
Affinity Capture-MS Homo sapiens
32 ATG9A 79065
Proximity Label-MS Homo sapiens
33 CNP 1267
Affinity Capture-MS Homo sapiens
34 ITPR1 3708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 DNAJC25 548645
Proximity Label-MS Homo sapiens
36 SFTPA2  
Affinity Capture-MS Homo sapiens
37 B3GALT4  
Affinity Capture-MS Homo sapiens
38 CD79A  
Affinity Capture-MS Homo sapiens
39 FKBP8 23770
Proximity Label-MS Homo sapiens
40 AQP3  
Affinity Capture-MS Homo sapiens
41 CACNG7  
Affinity Capture-MS Homo sapiens
42 AGK 55750
Affinity Capture-MS Homo sapiens
43 FFAR1  
Affinity Capture-MS Homo sapiens
44 ATP7A 538
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 APOD 347
Affinity Capture-MS Homo sapiens
46 CHML  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 VSIG4  
Affinity Capture-MS Homo sapiens
48 ALPI  
Affinity Capture-MS Homo sapiens
49 LRRC25  
Affinity Capture-MS Homo sapiens
50 ARL8B 55207
Affinity Capture-MS Homo sapiens
51 FPR2  
Affinity Capture-MS Homo sapiens
52 LSM7  
Two-hybrid Homo sapiens
53 CLEC4E  
Affinity Capture-MS Homo sapiens
54 GP5 2814
Affinity Capture-MS Homo sapiens
55 TMED10 10972
Affinity Capture-MS Homo sapiens
56 PLA1A  
Affinity Capture-MS Homo sapiens
57 LRRK2 120892
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
58 GPR45  
Affinity Capture-MS Homo sapiens
59 RAB7A 7879
Proximity Label-MS Homo sapiens
60 TRIM32 22954
Two-hybrid Homo sapiens
61 HLA-B 3106
Affinity Capture-MS Homo sapiens
62 GPR182  
Affinity Capture-MS Homo sapiens
63 TRIM27  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 BAG5 9529
Affinity Capture-Western Homo sapiens
65 BEND7 222389
Two-hybrid Homo sapiens
66 TMEM9 252839
Affinity Capture-MS Homo sapiens
67 LDOC1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 GPR55  
Affinity Capture-MS Homo sapiens
69 CNOT6L 246175
Affinity Capture-MS Homo sapiens
70 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
71 SLC1A1 6505
Affinity Capture-MS Homo sapiens
72 GPR84  
Affinity Capture-MS Homo sapiens
73 CHM 1121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 RHOT2 89941
Proximity Label-MS Homo sapiens
75 PTPRO 5800
Affinity Capture-MS Homo sapiens
76 AKAP1 8165
Proximity Label-MS Homo sapiens
77 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 KCNE4  
Affinity Capture-MS Homo sapiens
79 CLDN10  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RAB29 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Post-translational protein modification TAS Reactome
RAB geranylgeranylation TAS Reactome





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