Gene description for JPH1
Gene name junctophilin 1
Gene symbol JPH1
Other names/aliases JP-1
JP1
Species Homo sapiens
 Database cross references - JPH1
ExoCarta ExoCarta_56704
Vesiclepedia VP_56704
Entrez Gene 56704
HGNC 14201
MIM 605266
UniProt Q9HDC5  
 JPH1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for JPH1
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of muscle GO:0008307 IEA
Biological Process
    muscle organ development GO:0007517 IEA
    regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 TAS
    calcium ion transport into cytosol GO:0060402 TAS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    plasma membrane GO:0005886 IBA
    junctional sarcoplasmic reticulum membrane GO:0014701 TAS
    sarcoplasmic reticulum GO:0016529 IBA
    Z disc GO:0030018 IEA
    junctional membrane complex GO:0030314 IBA
    junctional membrane complex GO:0030314 NAS
 Experiment description of studies that identified JPH1 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for JPH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAMKV 79012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 Chek2  
Affinity Capture-MS Mus musculus
3 EMP1  
Two-hybrid Homo sapiens
4 HSD17B11 51170
Proximity Label-MS Homo sapiens
5 Tmed2 56334
Affinity Capture-MS Mus musculus
6 OCLN 100506658
Proximity Label-MS Homo sapiens
7 MARCKS 4082
Proximity Label-MS Homo sapiens
8 LAMP3  
Proximity Label-MS Homo sapiens
9 GJA1 2697
Proximity Label-MS Homo sapiens
10 GPR161  
Affinity Capture-MS Homo sapiens
11 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LOC100507537  
Two-hybrid Homo sapiens
13 HTATIP2 10553
Two-hybrid Homo sapiens
14 TMEM9B 56674
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 LAMP2 3920
Proximity Label-MS Homo sapiens
16 DNAJC25 548645
Proximity Label-MS Homo sapiens
17 TBC1D8  
Affinity Capture-MS Homo sapiens
18 PTPN1 5770
Proximity Label-MS Homo sapiens
19 STX4 6810
Proximity Label-MS Homo sapiens
20 TNFSF18 8995
Affinity Capture-MS Homo sapiens
21 TEX264 51368
Affinity Capture-MS Homo sapiens
22 B3GAT1  
Proximity Label-MS Homo sapiens
23 TMEM65 157378
Two-hybrid Homo sapiens
24 Rpl35 66489
Affinity Capture-MS Mus musculus
25 Naa50  
Affinity Capture-MS Mus musculus
26 RAB3B 5865
Proximity Label-MS Homo sapiens
27 TRDN 10345
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ZNF460  
Affinity Capture-MS Homo sapiens
29 MAGEA9  
Affinity Capture-MS Homo sapiens
30 TNFRSF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SSR1 6745
Proximity Label-MS Homo sapiens
32 GJD3  
Proximity Label-MS Homo sapiens
33 DNAJC16  
Proximity Label-MS Homo sapiens
34 Ubr5  
Affinity Capture-MS Mus musculus
35 SLC25A46 91137
Proximity Label-MS Homo sapiens
36 CYP2C9  
Proximity Label-MS Homo sapiens
37 RAB35 11021
Proximity Label-MS Homo sapiens
38 ATP13A3 79572
Affinity Capture-MS Homo sapiens
39 EBAG9 9166
Proximity Label-MS Homo sapiens
40 MCAM 4162
Proximity Label-MS Homo sapiens
41 LEPROTL1 23484
Two-hybrid Homo sapiens
42 METTL7A 25840
Proximity Label-MS Homo sapiens
43 LAMTOR1 55004
Proximity Label-MS Homo sapiens
44 GPR156  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 LMAN1 3998
Proximity Label-MS Homo sapiens
46 NUP155 9631
Proximity Label-MS Homo sapiens
47 KIAA1715 80856
Proximity Label-MS Homo sapiens
48 C1orf186  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RAB5A 5868
Proximity Label-MS Homo sapiens
50 PANX1 24145
Proximity Label-MS Homo sapiens
51 SEC63 11231
Proximity Label-MS Homo sapiens
52 MCC 4163
Affinity Capture-MS Homo sapiens
53 EMD 2010
Proximity Label-MS Homo sapiens
54 CXADR 1525
Proximity Label-MS Homo sapiens
55 CLSTN1 22883
Affinity Capture-MS Homo sapiens
56 KRBA1  
Affinity Capture-MS Homo sapiens
57 EIF2B5 8893
Affinity Capture-MS Homo sapiens
58 LYN 4067
Proximity Label-MS Homo sapiens
59 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 RAB4A 5867
Proximity Label-MS Homo sapiens
61 DNAJC5 80331
Proximity Label-MS Homo sapiens
62 GPR182  
Affinity Capture-MS Homo sapiens
63 MEOX2  
Two-hybrid Homo sapiens
64 STX6 10228
Proximity Label-MS Homo sapiens
65 DHFRL1  
Proximity Label-MS Homo sapiens
66 RHOT2 89941
Proximity Label-MS Homo sapiens
67 ELOVL5 60481
Proximity Label-MS Homo sapiens
68 SEC61B 10952
Proximity Label-MS Homo sapiens
69 RMDN3 55177
Proximity Label-MS Homo sapiens
70 KDF1  
Affinity Capture-MS Homo sapiens
71 ZNF543  
Affinity Capture-MS Homo sapiens
72 REEP5 7905
Proximity Label-MS Homo sapiens
73 KCNS3 3790
Affinity Capture-MS Homo sapiens
74 TNFRSF1A 7132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 TTC30A 92104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 Hsf1  
Affinity Capture-MS Mus musculus
77 SV2A 9900
Affinity Capture-MS Homo sapiens
78 CXCR4 7852
Affinity Capture-MS Homo sapiens
79 RPN2 6185
Proximity Label-MS Homo sapiens
80 RTN2 6253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 LRRC59 55379
Proximity Label-MS Homo sapiens
82 LMNB1 4001
Proximity Label-MS Homo sapiens
83 ZCCHC10  
Affinity Capture-MS Homo sapiens
84 EPB41L4A 64097
Proximity Label-MS Homo sapiens
85 LAMP1 3916
Proximity Label-MS Homo sapiens
86 PTH2R  
Affinity Capture-MS Homo sapiens
87 CD6 923
Affinity Capture-MS Homo sapiens
88 BCAP31 10134
Proximity Label-MS Homo sapiens
89 HSD3B7 80270
Proximity Label-MS Homo sapiens
90 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
91 STIM1 6786
Proximity Label-MS Homo sapiens
92 WDR55  
Affinity Capture-MS Homo sapiens
93 NIPAL1  
Affinity Capture-MS Homo sapiens
94 FKBP8 23770
Proximity Label-MS Homo sapiens
95 SLC16A13 201232
Two-hybrid Homo sapiens
96 ARF6 382
Proximity Label-MS Homo sapiens
97 TP73  
Affinity Capture-Western Homo sapiens
98 CCDC85A  
Affinity Capture-MS Homo sapiens
99 PRKACA 5566
Proximity Label-MS Homo sapiens
100 CUL9  
Affinity Capture-MS Homo sapiens
101 GPR42  
Two-hybrid Homo sapiens
102 TMED10 10972
Affinity Capture-MS Homo sapiens
103 FAM134C 162427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 ATP2A1 487
Proximity Label-MS Homo sapiens
105 ZMYND8 23613
Affinity Capture-MS Homo sapiens
106 RAB9A 9367
Proximity Label-MS Homo sapiens
107 TP63  
Affinity Capture-Western Homo sapiens
108 RIPK4  
Affinity Capture-MS Homo sapiens
109 RPN1 6184
Proximity Label-MS Homo sapiens
110 B3GAT3 26229
Affinity Capture-MS Homo sapiens
111 RHOB 388
Proximity Label-MS Homo sapiens
112 XRCC3  
Affinity Capture-MS Homo sapiens
113 MIER2  
Affinity Capture-MS Homo sapiens
114 Mad2l1 56150
Affinity Capture-MS Mus musculus
115 BRD3 8019
Affinity Capture-MS Homo sapiens
116 PDE3A  
Affinity Capture-MS Homo sapiens
117 EDDM3B  
Two-hybrid Homo sapiens
118 FLOT1 10211
Proximity Label-MS Homo sapiens
119 AVPR2  
Affinity Capture-MS Homo sapiens
120 KCNH2  
Affinity Capture-MS Homo sapiens
121 STARD8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 ARRB2 409
Affinity Capture-MS Homo sapiens
123 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
124 Tubgcp5  
Affinity Capture-MS Mus musculus
125 TMEM9 252839
Affinity Capture-MS Homo sapiens
126 PLP1 5354
Two-hybrid Homo sapiens
127 SCYL3 57147
Affinity Capture-MS Homo sapiens
128 RFWD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 Myo1c 17913
Affinity Capture-MS Mus musculus
130 TMEM120B  
Two-hybrid Homo sapiens
131 LCK 3932
Proximity Label-MS Homo sapiens
132 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
133 GBA 2629
Affinity Capture-MS Homo sapiens
134 ERGIC1 57222
Proximity Label-MS Homo sapiens
135 C11orf52 91894
Proximity Label-MS Homo sapiens
136 CHRM3 1131
Affinity Capture-MS Homo sapiens
137 PXMP2  
Proximity Label-MS Homo sapiens
138 SKAP1 8631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 ERGIC2 51290
Proximity Label-MS Homo sapiens
140 EDA  
Affinity Capture-MS Homo sapiens
141 ST14 6768
Affinity Capture-MS Homo sapiens
142 RAB2A 5862
Proximity Label-MS Homo sapiens
143 SEC62 7095
Proximity Label-MS Homo sapiens
144 DNAJC5B  
Proximity Label-MS Homo sapiens
145 RAB7A 7879
Proximity Label-MS Homo sapiens
146 ATP1A1 476
Affinity Capture-MS Homo sapiens
147 RAB11A 8766
Proximity Label-MS Homo sapiens
148 BRD1 23774
Affinity Capture-MS Homo sapiens
149 EPHA2 1969
Proximity Label-MS Homo sapiens
150 DNAJC1 64215
Proximity Label-MS Homo sapiens
151 KRAS 3845
Proximity Label-MS Homo sapiens
152 RAB5C 5878
Proximity Label-MS Homo sapiens
153 ADGRE5 976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 NAT8  
Two-hybrid Homo sapiens
155 CCDC47 57003
Affinity Capture-MS Homo sapiens
156 CKAP4 10970
Proximity Label-MS Homo sapiens
157 CAV1 857
Proximity Label-MS Homo sapiens
158 NOL9 79707
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
159 ARHGAP12  
Affinity Capture-MS Homo sapiens
160 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which JPH1 is involved
No pathways found





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