Gene description for MCC
Gene name mutated in colorectal cancers
Gene symbol MCC
Other names/aliases MCC1
Species Homo sapiens
 Database cross references - MCC
ExoCarta ExoCarta_4163
Vesiclepedia VP_4163
Entrez Gene 4163
HGNC 6935
MIM 159350
UniProt P23508  
 MCC identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MCC
Molecular Function
    protein binding GO:0005515 IPI
    receptor activity GO:0004872 TAS
Biological Process
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    negative regulation of epithelial cell proliferation GO:0050680 IDA
    establishment of protein localization GO:0045184 IDA
    signal transduction GO:0007165 TAS
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of epithelial cell migration GO:0010633 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    lamellipodium GO:0030027 IEA
    nucleus GO:0005634 IDA
    plasma membrane GO:0005886 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified MCC in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MCC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF3A 8661
Affinity Capture-MS Homo sapiens
2 STRIP1 85369
Affinity Capture-MS Homo sapiens
3 KRT18 3875
Affinity Capture-MS Homo sapiens
4 VPS35 55737
Affinity Capture-MS Homo sapiens
5 STK24 8428
Affinity Capture-MS Homo sapiens
6 CBR1 873
Affinity Capture-MS Homo sapiens
7 PSME3 10197
Affinity Capture-MS Homo sapiens
8 PFKP 5214
Affinity Capture-MS Homo sapiens
9 STRN4 29888
Affinity Capture-MS Homo sapiens
10 EZR 7430
Affinity Capture-MS Homo sapiens
11 DFFA 1676
Affinity Capture-MS Homo sapiens
12 PAICS 10606
Affinity Capture-MS Homo sapiens
13 STRN3 29966
Affinity Capture-MS Homo sapiens
14 VHL  
Affinity Capture-MS Homo sapiens
15 PDCD10 11235
Affinity Capture-MS Homo sapiens
16 EPRS 2058
Affinity Capture-MS Homo sapiens
17 TARS 6897
Affinity Capture-MS Homo sapiens
18 MARS 4141
Affinity Capture-MS Homo sapiens
19 SNRNP200 23020
Affinity Capture-MS Homo sapiens
20 CSNK1D 1453
Affinity Capture-MS Homo sapiens
21 STRN 6801
Affinity Capture-MS Homo sapiens
22 PSMD2 5708
Affinity Capture-MS Homo sapiens
23 VCP 7415
Affinity Capture-MS Homo sapiens
24 HPRT1 3251
Affinity Capture-MS Homo sapiens
25 MTHFD1 4522
Affinity Capture-MS Homo sapiens
26 CCNA1  
Affinity Capture-MS Homo sapiens
27 CSNK1E 1454
Affinity Capture-MS Homo sapiens
28 MYH10 4628
Affinity Capture-MS Homo sapiens
29 VDAC1 7416
Affinity Capture-MS Homo sapiens
30 CLTC 1213
Affinity Capture-MS Homo sapiens
31 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
32 IARS 3376
Affinity Capture-MS Homo sapiens
33 LTA4H 4048
Affinity Capture-MS Homo sapiens
34 TPM3 7170
Affinity Capture-MS Homo sapiens
35 PFAS 5198
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MCC is involved
No pathways found





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