Gene description for MCC
Gene name mutated in colorectal cancers
Gene symbol MCC
Other names/aliases MCC1
Species Homo sapiens
 Database cross references - MCC
ExoCarta ExoCarta_4163
Vesiclepedia VP_4163
Entrez Gene 4163
HGNC 6935
MIM 159350
UniProt P23508  
 MCC identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MCC
Molecular Function
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 TAS
Biological Process
    signal transduction GO:0007165 TAS
    negative regulation of epithelial cell migration GO:0010633 IMP
    Wnt signaling pathway GO:0016055 IEA
    establishment of protein localization GO:0045184 IDA
    negative regulation of epithelial cell proliferation GO:0050680 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    lamellipodium GO:0030027 IEA
 Experiment description of studies that identified MCC in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MCC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RALY 22913
Affinity Capture-MS Homo sapiens
2 MCRS1  
Affinity Capture-MS Homo sapiens
3 VPS35 55737
Affinity Capture-MS Homo sapiens
4 KRT37 8688
Affinity Capture-MS Homo sapiens
5 CEP95  
Two-hybrid Homo sapiens
6 EIF3A 8661
Affinity Capture-MS Homo sapiens
7 PER1  
Affinity Capture-MS Homo sapiens
8 BLOC1S6  
Affinity Capture-MS Homo sapiens
9 ZNF438  
Two-hybrid Homo sapiens
10 NOL12 79159
Two-hybrid Homo sapiens
11 KIFC3 3801
Two-hybrid Homo sapiens
12 PFKP 5214
Affinity Capture-MS Homo sapiens
13 KLC3  
Affinity Capture-MS Homo sapiens
14 MED29  
Affinity Capture-MS Homo sapiens
15 JPH1 56704
Affinity Capture-MS Homo sapiens
16 PAICS 10606
Affinity Capture-MS Homo sapiens
17 DYNC1I1  
Two-hybrid Homo sapiens
18 STRN3 29966
Affinity Capture-MS Homo sapiens
19 VHL  
Affinity Capture-MS Homo sapiens
20 RBM12 10137
Affinity Capture-MS Homo sapiens
21 NDUFS2 4720
Affinity Capture-MS Homo sapiens
22 APP 351
Reconstituted Complex Homo sapiens
23 DECR1 1666
Affinity Capture-MS Homo sapiens
24 AGAP3 116988
Affinity Capture-MS Homo sapiens
25 ZNF3  
Two-hybrid Homo sapiens
26 PDCD10 11235
Affinity Capture-MS Homo sapiens
27 ZNF648  
Two-hybrid Homo sapiens
28 NDE1 54820
Affinity Capture-MS Homo sapiens
29 YWHAZ 7534
Affinity Capture-MS Homo sapiens
30 STRN 6801
Affinity Capture-MS Homo sapiens
31 GTF2E2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
32 CEP57L1  
Two-hybrid Homo sapiens
33 RASAL2 9462
Affinity Capture-MS Homo sapiens
34 ESRRG  
Two-hybrid Homo sapiens
35 IMP3 55272
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
36 TRIOBP 11078
Affinity Capture-MS Homo sapiens
37 POLL  
Two-hybrid Homo sapiens
38 SCRIB 23513
Affinity Capture-MS Homo sapiens
39 LTA4H 4048
Affinity Capture-MS Homo sapiens
40 CCDC112  
Two-hybrid Homo sapiens
41 BRPF3  
Affinity Capture-MS Homo sapiens
42 YWHAG 7532
Affinity Capture-MS Homo sapiens
43 PLD1 5337
Affinity Capture-MS Homo sapiens
44 ZNF35  
Two-hybrid Homo sapiens
45 ZNF202  
Two-hybrid Homo sapiens
46 STRIP1 85369
Affinity Capture-MS Homo sapiens
47 POLR1E  
Affinity Capture-MS Homo sapiens
48 SNX27 81609
Affinity Capture-MS Homo sapiens
49 POLR3A 11128
Affinity Capture-MS Homo sapiens
50 CSNK1D 1453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CEP290  
Affinity Capture-MS Homo sapiens
52 TCEANC  
Two-hybrid Homo sapiens
53 CEP131 22994
Affinity Capture-MS Homo sapiens
54 DIP2A 23181
Affinity Capture-MS Homo sapiens
55 RCOR3  
Two-hybrid Homo sapiens
56 CCDC83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 EXOC3 11336
Affinity Capture-MS Homo sapiens
58 YWHAB 7529
Affinity Capture-MS Homo sapiens
59 PTPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
60 TSHZ2  
Two-hybrid Homo sapiens
61 UBR4 23352
Affinity Capture-MS Homo sapiens
62 CEP350 9857
Affinity Capture-MS Homo sapiens
63 SNX33 257364
Affinity Capture-MS Homo sapiens
64 MOB4 25843
Affinity Capture-MS Homo sapiens
65 LUZP1 7798
Affinity Capture-MS Homo sapiens
66 GTF2H4 2968
Affinity Capture-MS Homo sapiens
67 CCAR2 57805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 TCEA2  
Two-hybrid Homo sapiens
69 MARS 4141
Affinity Capture-MS Homo sapiens
70 ZMYM1 79830
Affinity Capture-MS Homo sapiens
71 FGF16 8823
Two-hybrid Homo sapiens
72 ZBTB48  
Two-hybrid Homo sapiens
73 GTF2H1 2965
Affinity Capture-MS Homo sapiens
74 SNRNP200 23020
Affinity Capture-MS Homo sapiens
75 MCM10 55388
Affinity Capture-MS Homo sapiens
76 SP110  
Affinity Capture-MS Homo sapiens
77 YWHAE 7531
Affinity Capture-MS Homo sapiens
78 VCP 7415
Affinity Capture-MS Homo sapiens
79 CBX5 23468
Two-hybrid Homo sapiens
80 CRY2  
Affinity Capture-MS Homo sapiens
81 CSNK1E 1454
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 LRRC45  
Two-hybrid Homo sapiens
83 PRPF18  
Two-hybrid Homo sapiens
84 EFCAB7  
Affinity Capture-MS Homo sapiens
85 PCCA 5095
Two-hybrid Homo sapiens
86 IARS 3376
Affinity Capture-MS Homo sapiens
87 UTP14C  
Two-hybrid Homo sapiens
88 PSMD2 5708
Affinity Capture-MS Homo sapiens
89 AGAP2  
Affinity Capture-MS Homo sapiens
90 C8orf48  
Two-hybrid Homo sapiens
91 CD3EAP  
Affinity Capture-MS Homo sapiens
92 ZNF543  
Two-hybrid Homo sapiens
93 ZNF644  
Affinity Capture-MS Homo sapiens
94 PER2  
Affinity Capture-MS Homo sapiens
95 WHAMMP3  
Affinity Capture-MS Homo sapiens
96 GAPVD1 26130
Affinity Capture-MS Homo sapiens
97 STOX2  
Affinity Capture-MS Homo sapiens
98 KIF15 56992
Affinity Capture-MS Homo sapiens
99 CCDC185  
Two-hybrid Homo sapiens
100 ANKS1B 56899
Affinity Capture-MS Homo sapiens
101 SYT6  
Two-hybrid Homo sapiens
102 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 KCMF1 56888
Affinity Capture-MS Homo sapiens
104 CERK 64781
Affinity Capture-MS Homo sapiens
105 DAB2IP 153090
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
107 DACH1  
Affinity Capture-MS Homo sapiens
108 MTNR1A  
Two-hybrid Homo sapiens
109 RNF138  
Affinity Capture-MS Homo sapiens
110 KANSL2  
Affinity Capture-MS Homo sapiens
111 EPRS 2058
Affinity Capture-MS Homo sapiens
112 ARRB2 409
Affinity Capture-MS Homo sapiens
113 SLTM 79811
Two-hybrid Homo sapiens
114 SYT17  
Two-hybrid Homo sapiens
115 Csnk1e  
Affinity Capture-MS Mus musculus
116 DYX1C1  
Two-hybrid Homo sapiens
117 CBY1  
Affinity Capture-MS Homo sapiens
118 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
119 ZNF12  
Two-hybrid Homo sapiens
120 FAM208A  
Affinity Capture-MS Homo sapiens
121 MGC50722  
Two-hybrid Homo sapiens
122 MYO9B 4650
Affinity Capture-MS Homo sapiens
123 KAT5  
Two-hybrid Homo sapiens
124 HPRT1 3251
Affinity Capture-MS Homo sapiens
125 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
126 BBX 56987
Affinity Capture-MS Homo sapiens
127 CCNA1  
Affinity Capture-MS Homo sapiens
128 VDAC1 7416
Affinity Capture-MS Homo sapiens
129 CLTC 1213
Affinity Capture-MS Homo sapiens
130 SLU7  
Two-hybrid Homo sapiens
131 UACA 55075
Affinity Capture-MS Homo sapiens
132 ASH1L 55870
Affinity Capture-MS Homo sapiens
133 MYH10 4628
Affinity Capture-MS Homo sapiens
134 FOXK1 221937
Affinity Capture-MS Homo sapiens
135 ZNF417  
Two-hybrid Homo sapiens
136 TPM3 7170
Affinity Capture-MS Homo sapiens
137 PFAS 5198
Affinity Capture-MS Homo sapiens
138 KRT18 3875
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 RBM14 10432
Affinity Capture-MS Homo sapiens
140 C8orf33 65265
Two-hybrid Homo sapiens
141 STK24 8428
Affinity Capture-MS Homo sapiens
142 STX16 8675
Affinity Capture-MS Homo sapiens
143 RAB11FIP5 26056
Affinity Capture-MS Homo sapiens
144 DFNB31  
Affinity Capture-MS Homo sapiens
145 IQCE 23288
Affinity Capture-MS Homo sapiens
146 CCDC146  
Two-hybrid Homo sapiens
147 STRN4 29888
Affinity Capture-MS Homo sapiens
148 EZR 7430
Affinity Capture-MS Homo sapiens
149 DFFA 1676
Affinity Capture-MS Homo sapiens
150 PLCD3 113026
Affinity Capture-MS Homo sapiens
151 CBR1 873
Affinity Capture-MS Homo sapiens
152 PSME3 10197
Affinity Capture-MS Homo sapiens
153 CAPZB 832
Affinity Capture-MS Homo sapiens
154 HSP90AA1 3320
Cross-Linking-MS (XL-MS) Homo sapiens
155 MTHFD1 4522
Affinity Capture-MS Homo sapiens
156 TARS 6897
Affinity Capture-MS Homo sapiens
157 ZNF792 126375
Two-hybrid Homo sapiens
158 MAGEE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
159 THAP7  
Two-hybrid Homo sapiens
160 ERCC3  
Affinity Capture-MS Homo sapiens
161 ZNF497  
Two-hybrid Homo sapiens
162 HOXC9  
Affinity Capture-MS Homo sapiens
163 NEK2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
164 KRT38 8687
Affinity Capture-MS Homo sapiens
165 AMOTL2 51421
Affinity Capture-MS Homo sapiens
166 WDR76  
Affinity Capture-MS Homo sapiens
167 FAM161A  
Two-hybrid Homo sapiens
168 PCGF6  
Affinity Capture-MS Homo sapiens
169 CBX8 57332
Two-hybrid Homo sapiens
170 SLC9A3R1 9368
Affinity Capture-MS Homo sapiens
171 CEP78 84131
Affinity Capture-MS Homo sapiens
172 BRD1 23774
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 CFAP58 159686
Two-hybrid Homo sapiens
174 HOXB9  
Affinity Capture-MS Homo sapiens
175 DZIP1  
Affinity Capture-MS Homo sapiens
176 NFKBIB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 PTRF 284119
Affinity Capture-MS Homo sapiens
178 FAM92A1  
Affinity Capture-MS Homo sapiens
179 ZNF865  
Affinity Capture-MS Homo sapiens
180 ZNF770 54989
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MCC is involved
No pathways found





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