Gene description for FGF16
Gene name fibroblast growth factor 16
Gene symbol FGF16
Other names/aliases FGF-16
MF4
Species Homo sapiens
 Database cross references - FGF16
ExoCarta ExoCarta_8823
Vesiclepedia VP_8823
Entrez Gene 8823
HGNC 3672
MIM 300827
UniProt O43320  
 FGF16 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for FGF16
Molecular Function
    fibroblast growth factor receptor binding GO:0005104 IBA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IBA
Biological Process
    regulation of endothelial cell proliferation GO:0001936 IDA
    signal transduction GO:0007165 TAS
    cell-cell signaling GO:0007267 TAS
    positive regulation of cell population proliferation GO:0008284 IBA
    fibroblast growth factor receptor signaling pathway GO:0008543 IBA
    response to temperature stimulus GO:0009266 TAS
    animal organ morphogenesis GO:0009887 TAS
    neurogenesis GO:0022008 IBA
    regulation of cell migration GO:0030334 IBA
    regulation of MAP kinase activity GO:0043405 IDA
    positive regulation of MAPK cascade GO:0043410 IBA
    regulation of sprouting angiogenesis GO:1903670 IDA
    positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified FGF16 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for FGF16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 TMED7 51014
Affinity Capture-MS Homo sapiens
3 INCA1  
Two-hybrid Homo sapiens
4 MCC 4163
Two-hybrid Homo sapiens
5 CLP1  
Two-hybrid Homo sapiens
6 DVL3 1857
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FGF16 is involved
PathwayEvidenceSource
Activated point mutants of FGFR2 TAS Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream signaling of activated FGFR2 TAS Reactome
Downstream signaling of activated FGFR3 TAS Reactome
Downstream signaling of activated FGFR4 TAS Reactome
FGFR2 ligand binding and activation TAS Reactome
FGFR2 mutant receptor activation TAS Reactome
FGFR2c ligand binding and activation TAS Reactome
FGFR3 ligand binding and activation TAS Reactome
FGFR3 mutant receptor activation TAS Reactome
FGFR3c ligand binding and activation TAS Reactome
FGFR4 ligand binding and activation TAS Reactome
FRS-mediated FGFR2 signaling TAS Reactome
FRS-mediated FGFR3 signaling TAS Reactome
FRS-mediated FGFR4 signaling TAS Reactome
IGF1R signaling cascade TAS Reactome
Insulin receptor signalling cascade TAS Reactome
Intracellular signaling by second messengers TAS Reactome
IRS-mediated signalling TAS Reactome
IRS-related events triggered by IGF1R TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Negative regulation of FGFR2 signaling TAS Reactome
Negative regulation of FGFR3 signaling TAS Reactome
Negative regulation of FGFR4 signaling TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Phospholipase C-mediated cascade; FGFR2 TAS Reactome
Phospholipase C-mediated cascade; FGFR3 TAS Reactome
Phospholipase C-mediated cascade; FGFR4 TAS Reactome
PI-3K cascade:FGFR2 TAS Reactome
PI-3K cascade:FGFR3 TAS Reactome
PI-3K cascade:FGFR4 TAS Reactome
PI3K Cascade TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
RAF/MAP kinase cascade TAS Reactome
SHC-mediated cascade:FGFR2 TAS Reactome
SHC-mediated cascade:FGFR3 TAS Reactome
SHC-mediated cascade:FGFR4 TAS Reactome
Signal Transduction TAS Reactome
Signaling by activated point mutants of FGFR3 TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR in disease TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR2 in disease TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR3 in disease TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) TAS Reactome





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