ExoCarta: Gene summary

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Gene description for ZNF770
Gene name	zinc finger protein 770
Gene symbol	ZNF770
Other names/aliases	PRO1914
Species	Homo sapiens
Database cross references - ZNF770
ExoCarta	ExoCarta_54989
Entrez Gene	54989
HGNC	26061
UniProt	Q6IQ21
ZNF770 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for ZNF770

Molecular Function
	DNA binding	GO:0003677	IEA
	sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:0000981	IBA
	metal ion binding	GO:0046872	IEA
Biological Process
	transcription from RNA polymerase II promoter	GO:0006366	IBA
	regulation of transcription from RNA polymerase II promoter	GO:0006357	IBA
Subcellular Localization
	nucleus	GO:0005634	IBA

Experiment description of studies that identified ZNF770 in exosomes

Experiment ID

235

ISEV standards
✔ EM	EV Biophysical techniques
✔ TSG101\|Alix\|HSC70\|GAPDH	EV Cytosolic markers
✘	EV Membrane markers
✔ HSP90B1	EV Negative markers
✔ qNano	EV Particle analysis

Identified molecule

mRNA

Identification method

RNA Sequencing

PubMed ID

26054723

Organism

Homo sapiens

Experiment description

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

Authors

He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N

Journal name

Carcinogenesis

Publication year

2015

Sample

Hepatocellular carcinoma cells

Sample name

HKCI-8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient

Flotation density

1.13-1.19 g/mL

Molecules identified in the study

Protein
RNA

Methods used in the study

Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing