Gene description for CFAP58
Gene name cilia and flagella associated protein 58
Gene symbol CFAP58
Other names/aliases C10orf80
CCDC147
bA127L20.4
bA127L20.5
bA554P13.1
Species Homo sapiens
 Database cross references - CFAP58
ExoCarta ExoCarta_159686
Vesiclepedia VP_159686
Entrez Gene 159686
HGNC 26676
UniProt Q5T655  
 CFAP58 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for CFAP58
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    Notch signaling pathway GO:0007219 ISS
    sperm axoneme assembly GO:0007288 IMP
    flagellated sperm motility GO:0030317 IMP
    cilium assembly GO:0060271 ISS
    protein localization to motile cilium GO:0120229 IMP
    sperm flagellum assembly GO:0120316 ISS
    sperm mitochondrial sheath assembly GO:0120317 IMP
Subcellular Localization
    extracellular space GO:0005615 HDA
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 ISS
    cytoskeleton GO:0005856 IBA
    sperm flagellum GO:0036126 IDA
    sperm midpiece GO:0097225 IMP
 Experiment description of studies that identified CFAP58 in sEVs
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CFAP58
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
2 COPS5 10987
Affinity Capture-MS Homo sapiens
3 KRT27 342574
Two-hybrid Homo sapiens
4 RIPPLY1  
Two-hybrid Homo sapiens
5 POT1  
Affinity Capture-MS Homo sapiens
6 TERF1 7013
Affinity Capture-MS Homo sapiens
7 MCC 4163
Two-hybrid Homo sapiens
8 XRN2 22803
Co-fractionation Homo sapiens
9 CAND1 55832
Affinity Capture-MS Homo sapiens
10 PARK2  
Affinity Capture-MS Homo sapiens
11 NAV2  
Two-hybrid Homo sapiens
12 BACH2 60468
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CFAP58 is involved
No pathways found





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