Gene description for AMOTL2
Gene name angiomotin like 2
Gene symbol AMOTL2
Other names/aliases LCCP
Species Homo sapiens
 Database cross references - AMOTL2
ExoCarta ExoCarta_51421
Vesiclepedia VP_51421
Entrez Gene 51421
HGNC 17812
MIM 614658
UniProt Q9Y2J4  
 AMOTL2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for AMOTL2
Molecular Function
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    angiogenesis GO:0001525 IBA
    endothelial cell morphogenesis GO:0001886 ISS
    establishment of cell polarity involved in ameboidal cell migration GO:0003365 IBA
    Wnt signaling pathway GO:0016055 IEA
    actin cytoskeleton organization GO:0030036 IBA
    regulation of cell migration GO:0030334 IBA
    hippo signaling GO:0035329 IBA
    positive regulation of protein localization GO:1903829 IDA
Subcellular Localization
    podosome GO:0002102 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    bicellular tight junction GO:0005923 IBA
    cell junction GO:0030054 ISS
    cytoplasmic vesicle GO:0031410 IBA
    cell projection GO:0042995 IEA
    recycling endosome GO:0055037 IEA
 Experiment description of studies that identified AMOTL2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AMOTL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAPPC9 83696
Affinity Capture-MS Homo sapiens
2 KRT1 3848
Two-hybrid Homo sapiens
3 SOGA1 140710
Two-hybrid Homo sapiens
4 WWP1 11059
Affinity Capture-MS Homo sapiens
5 YWHAE 7531
Affinity Capture-MS Homo sapiens
6 NUP62 23636
Affinity Capture-MS Homo sapiens
7 FAM184A 79632
Two-hybrid Homo sapiens
8 CCHCR1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 SMARCE1 6605
Two-hybrid Homo sapiens
10 BYSL 705
Two-hybrid Homo sapiens
11 USP9X 8239
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 FAM168A  
Affinity Capture-MS Homo sapiens
13 NFIL3 4783
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 EIF4E2  
Two-hybrid Homo sapiens
15 SNRPD2 6633
Affinity Capture-MS Homo sapiens
16 DZIP1L  
Two-hybrid Homo sapiens
17 APEX1 328
Affinity Capture-RNA Homo sapiens
18 MYO5B 4645
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
19 MPP5 64398
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
20 NME7 29922
Two-hybrid Homo sapiens
21 COPS6 10980
Affinity Capture-MS Homo sapiens
22 RASAL3 64926
Two-hybrid Homo sapiens
23 RNF8  
Two-hybrid Homo sapiens
24 YES1 7525
Two-hybrid Homo sapiens
25 MAGOHB 55110
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 PSMD9 5715
Affinity Capture-MS Homo sapiens
27 ZGPAT  
Two-hybrid Homo sapiens
28 YWHAG 7532
Affinity Capture-MS Homo sapiens
29 KRT31 3881
Two-hybrid Homo sapiens
30 DYNLL1 8655
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 RASSF5 83593
Two-hybrid Homo sapiens
32 YWHAH 7533
Affinity Capture-MS Homo sapiens
33 MPP1 4354
Two-hybrid Homo sapiens
34 INADL 10207
Affinity Capture-MS Homo sapiens
35 KRTAP4-2  
Two-hybrid Homo sapiens
36 Wwtr1  
Affinity Capture-MS Mus musculus
37 MYCN  
Affinity Capture-MS Homo sapiens
38 CARD9 64170
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 AMOT  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
40 TRAPPC10 7109
Affinity Capture-MS Homo sapiens
41 PSMC3 5702
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
42 KIF14 9928
Affinity Capture-MS Homo sapiens
43 CINP  
Two-hybrid Homo sapiens
44 YWHAB 7529
Affinity Capture-MS Homo sapiens
45 GSTM5 2949
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 SPAG5 10615
Two-hybrid Homo sapiens
47 NF2 4771
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
48 FCRL5  
Two-hybrid Homo sapiens
49 TSGA10IP  
Two-hybrid Homo sapiens
50 MCC 4163
Affinity Capture-MS Homo sapiens
51 HTATIP2 10553
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 ZBTB16  
Two-hybrid Homo sapiens
53 CHCHD3 54927
Two-hybrid Homo sapiens
54 TCEA2  
Two-hybrid Homo sapiens
55 GOLGA2 2801
Two-hybrid Homo sapiens
56 RNF146  
Affinity Capture-Luminescence Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
57 GCC1 79571
Two-hybrid Homo sapiens
58 YAP1 10413
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
59 WDYHV1  
Two-hybrid Homo sapiens
60 DTNB 1838
Two-hybrid Homo sapiens
61 LIN7C 55327
Affinity Capture-MS Homo sapiens
62 YWHAQ 10971
Affinity Capture-MS Homo sapiens
63 PRPF18  
Two-hybrid Homo sapiens
64 Tnks2  
Affinity Capture-MS Mus musculus
65 GALNS 2588
Affinity Capture-MS Homo sapiens
66 LMNB2 84823
Two-hybrid Homo sapiens
67 LATS2 26524
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
68 GNG5 2787
Two-hybrid Homo sapiens
69 LINC00238  
Two-hybrid Homo sapiens
70 MPDZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 DAXX  
Two-hybrid Homo sapiens
72 ZBED1  
Two-hybrid Homo sapiens
73 SP100 6672
Two-hybrid Homo sapiens
74 PARD3 56288
Affinity Capture-MS Homo sapiens
75 RNF40 9810
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
76 Lin7c 22343
Affinity Capture-MS Mus musculus
77 CCDC185  
Two-hybrid Homo sapiens
78 XPO1 7514
Affinity Capture-MS Homo sapiens
79 TNKS 8658
Affinity Capture-Luminescence Homo sapiens
80 MAD1L1  
Two-hybrid Homo sapiens
81 CCDC57 284001
Two-hybrid Homo sapiens
82 PRKAA2 5563
Two-hybrid Homo sapiens
83 ANXA1 301
Affinity Capture-MS Homo sapiens
84 MEX3A  
Affinity Capture-RNA Homo sapiens
85 GNG11 2791
Two-hybrid Homo sapiens
86 MTNR1A  
Two-hybrid Homo sapiens
87 BFSP2  
Two-hybrid Homo sapiens
88 SH3RF2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
89 TNKS2 80351
Affinity Capture-Luminescence Homo sapiens
Biochemical Activity Homo sapiens
90 FAM90A1  
Two-hybrid Homo sapiens
91 BRMS1L  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
92 THRA  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
93 RAD51D  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
94 KRT15 3866
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
95 SAAL1 113174
Two-hybrid Homo sapiens
96 MFAP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
97 MYC  
Affinity Capture-MS Homo sapiens
98 HECW2  
Affinity Capture-Western Homo sapiens
99 FXR2 9513
Two-hybrid Homo sapiens
100 FBXO2 26232
Affinity Capture-MS Homo sapiens
101 MAGEA4 4103
Two-hybrid Homo sapiens
102 TRIM27  
Two-hybrid Homo sapiens
103 NDC80 10403
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
104 Yap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
105 NEDD4 4734
Affinity Capture-MS Homo sapiens
106 KRT19 3880
Two-hybrid Homo sapiens
107 KRTAP10-5  
Two-hybrid Homo sapiens
108 LMO4  
Two-hybrid Homo sapiens
109 RALBP1 10928
Two-hybrid Homo sapiens
110 TP53BP2  
Affinity Capture-MS Homo sapiens
111 C7orf43  
Affinity Capture-MS Homo sapiens
112 SPOP  
Two-hybrid Homo sapiens
113 DYNLL2 140735
Affinity Capture-MS Homo sapiens
114 TRAF2 7186
Two-hybrid Homo sapiens
115 MKNK1  
Affinity Capture-MS Homo sapiens
116 SPP1 6696
Two-hybrid Homo sapiens
117 BLZF1  
Two-hybrid Homo sapiens
118 CDC37 11140
Two-hybrid Homo sapiens
119 CYTH4  
Two-hybrid Homo sapiens
120 MORF4L2  
Two-hybrid Homo sapiens
121 RNF20 56254
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
122 WWP2 11060
Affinity Capture-MS Homo sapiens
123 DDIT3 1649
Two-hybrid Homo sapiens
124 E2F4  
Affinity Capture-MS Homo sapiens
125 KRT20 54474
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
126 KRT38 8687
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
127 AMOTL2 51421
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
128 TRAPPC3 27095
Affinity Capture-MS Homo sapiens
129 CDR2  
Two-hybrid Homo sapiens
130 KRT13 3860
Two-hybrid Homo sapiens
131 TMCC2  
Two-hybrid Homo sapiens
132 MTMR6 9107
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which AMOTL2 is involved
PathwayEvidenceSource
Signal Transduction TAS Reactome
Signaling by Hippo TAS Reactome





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