Gene description for INADL
Gene name InaD-like (Drosophila)
Gene symbol INADL
Other names/aliases Cipp
InaD-like
PATJ
hINADL
Species Homo sapiens
 Database cross references - INADL
ExoCarta ExoCarta_10207
Vesiclepedia VP_10207
Entrez Gene 10207
HGNC 28881
MIM 603199
UniProt Q8NI35  
 INADL identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 19056867    
 Gene ontology annotations for INADL
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    establishment of apical/basal cell polarity GO:0035089 ISS
    intracellular signal transduction GO:0035556 NAS
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 NAS
    tight junction assembly GO:0120192 IBA
    tight junction assembly GO:0120192 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    bicellular tight junction GO:0005923 IBA
    bicellular tight junction GO:0005923 IDA
    apical plasma membrane GO:0016324 ISS
    apical plasma membrane GO:0016324 NAS
    cell junction GO:0030054 IDA
    centriolar satellite GO:0034451 IDA
    apical junction complex GO:0043296 NAS
    apical part of cell GO:0045177 IBA
    perinuclear region of cytoplasm GO:0048471 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified INADL in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
7
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
8
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for INADL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PARD3 56288
Proximity Label-MS Homo sapiens
2 ARHGAP17 55114
Affinity Capture-MS Homo sapiens
3 HOMER1  
Two-hybrid Homo sapiens
4 HOMER3 9454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SNCA 6622
Affinity Capture-MS Homo sapiens
6 C2CD4B  
Affinity Capture-MS Homo sapiens
7 Tmed2 56334
Affinity Capture-MS Mus musculus
8 Wwtr1  
Affinity Capture-MS Mus musculus
9 GJB2  
Affinity Capture-MS Homo sapiens
10 Lin7c 22343
Affinity Capture-MS Mus musculus
11 NECAB2  
Two-hybrid Homo sapiens
12 AMOT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
13 CEP170P1  
Affinity Capture-MS Homo sapiens
14 OCLN 100506658
Proximity Label-MS Homo sapiens
15 RNF166  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ANLN 54443
Affinity Capture-MS Homo sapiens
17 CINP  
Two-hybrid Homo sapiens
18 AMOTL2 51421
Affinity Capture-MS Homo sapiens
19 EPB41L4A 64097
Proximity Label-MS Homo sapiens
20 ANAPC15  
Affinity Capture-MS Homo sapiens
21 FAM124A  
Affinity Capture-MS Homo sapiens
22 RAB32 10981
Affinity Capture-MS Homo sapiens
23 GBA 2629
Affinity Capture-MS Homo sapiens
24 CAPZB 832
Co-fractionation Homo sapiens
25 METTL21B  
Affinity Capture-MS Homo sapiens
26 PHYH 5264
Two-hybrid Homo sapiens
27 MPP5 64398
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 WWC1  
Affinity Capture-MS Homo sapiens
29 GIPC2 54810
Two-hybrid Homo sapiens
30 LATS1  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
31 PSMD14 10213
Affinity Capture-MS Homo sapiens
32 HSF2  
Affinity Capture-MS Homo sapiens
33 LIN7A 8825
Affinity Capture-MS Homo sapiens
34 TJP3  
Reconstituted Complex Homo sapiens
35 RNF146  
Affinity Capture-Luminescence Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
36 RNASEH2A 10535
Affinity Capture-MS Homo sapiens
37 CDH1 999
Proximity Label-MS Homo sapiens
38 MLLT4 4301
Proximity Label-MS Homo sapiens
39 YAP1 10413
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 Tpx2  
Affinity Capture-MS Mus musculus
41 C16orf72 29035
Affinity Capture-MS Homo sapiens
42 FLOT1 10211
Proximity Label-MS Homo sapiens
43 SAV1  
Proximity Label-MS Homo sapiens
44 LIN7C 55327
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 Kif13b  
Affinity Capture-MS Mus musculus
46 CIT 11113
Affinity Capture-MS Homo sapiens
47 DTX2 113878
Proximity Label-MS Homo sapiens
48 TP53RK 112858
Affinity Capture-MS Homo sapiens
49 PRC1 9055
Affinity Capture-MS Homo sapiens
50 CEP57L1  
Two-hybrid Homo sapiens
51 Yap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Reconstituted Complex Mus musculus
52 RHOB 388
Proximity Label-MS Homo sapiens
53 Nedd1  
Affinity Capture-MS Mus musculus
54 CLDN1 9076
Reconstituted Complex Homo sapiens
55 Ufl1  
Affinity Capture-MS Mus musculus
56 LATS2 26524
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
57 FHL2 2274
Affinity Capture-MS Homo sapiens
58 LIN7B  
Affinity Capture-MS Homo sapiens
59 Plekhg5  
Affinity Capture-MS Mus musculus
60 SLC33A1 9197
Affinity Capture-MS Homo sapiens
61 LURAP1  
Affinity Capture-MS Homo sapiens
62 PCDHAC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 BAI1  
Protein-peptide Homo sapiens
View the network image/svg+xml
 Pathways in which INADL is involved
No pathways found





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