Gene description for GNG11
Gene name guanine nucleotide binding protein (G protein), gamma 11
Gene symbol GNG11
Other names/aliases GNGT11
Species Homo sapiens
 Database cross references - GNG11
ExoCarta ExoCarta_2791
Vesiclepedia VP_2791
Entrez Gene 2791
HGNC 4403
MIM 604390
UniProt P61952  
 GNG11 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for GNG11
Molecular Function
    GTPase activity GO:0003924 TAS
    signal transducer activity GO:0004871 IEA
Biological Process
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    small molecule metabolic process GO:0044281 TAS
    cellular response to glucagon stimulus GO:0071377 TAS
    energy reserve metabolic process GO:0006112 TAS
    signal transduction GO:0007165 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    heterotrimeric G-protein complex GO:0005834 IEA
 Experiment description of studies that identified GNG11 in exosomes
1
Experiment ID 275
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
EV Enriched markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for GNG11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZHX1  
Two-hybrid Homo sapiens
2 GNB1 2782
Reconstituted Complex Homo sapiens
3 AMOTL2 51421
Two-hybrid Homo sapiens
View the network image/svg+xml



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