Gene description for GCC1
Gene name GRIP and coiled-coil domain containing 1
Gene symbol GCC1
Other names/aliases GCC1P
GCC88
Species Homo sapiens
 Database cross references - GCC1
ExoCarta ExoCarta_79571
Vesiclepedia VP_79571
Entrez Gene 79571
HGNC 19095
MIM 607418
UniProt Q96CN9  
 GCC1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GCC1
Molecular Function
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 ISS
Subcellular Localization
    Golgi trans cisterna GO:0000138 ISS
    Golgi membrane GO:0000139 IEA
    Golgi apparatus GO:0005794 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified GCC1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GCC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP6V1B2 526
Co-fractionation Homo sapiens
2 Cdk1 12534
Affinity Capture-MS Mus musculus
3 NECAB2  
Two-hybrid Homo sapiens
4 XIAP  
Two-hybrid Homo sapiens
5 COIL  
Two-hybrid Homo sapiens
6 ATG9A 79065
Proximity Label-MS Homo sapiens
7 GJA1 2697
Proximity Label-MS Homo sapiens
8 AES 166
Two-hybrid Homo sapiens
9 BRCA1 672
Two-hybrid Homo sapiens
10 DISC1 27185
Two-hybrid Homo sapiens
11 PPP1R27  
Two-hybrid Homo sapiens
12 GAS8  
Two-hybrid Homo sapiens
13 LNPEP 4012
Affinity Capture-MS Homo sapiens
14 ATN1  
Two-hybrid Homo sapiens
15 APP 351
Reconstituted Complex Homo sapiens
16 XRCC1 7515
Affinity Capture-MS Homo sapiens
17 B3GAT1  
Proximity Label-MS Homo sapiens
18 CEP70  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
19 KATNAL1  
Two-hybrid Homo sapiens
20 NAV1 89796
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 KIF5B 3799
Two-hybrid Homo sapiens
22 PPP1R18 170954
Two-hybrid Homo sapiens
23 TRIM50  
Two-hybrid Homo sapiens
24 CPSF7 79869
Two-hybrid Homo sapiens
25 FBXO28  
Two-hybrid Homo sapiens
26 OIP5  
Two-hybrid Homo sapiens
27 TFIP11  
Two-hybrid Homo sapiens
28 TINF2  
Affinity Capture-MS Homo sapiens
29 STX6 10228
Proximity Label-MS Homo sapiens
30 FIGNL1 63979
Two-hybrid Homo sapiens
31 CEP57  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 ARL1 400
Two-hybrid Homo sapiens
33 EBAG9 9166
Proximity Label-MS Homo sapiens
34 MED4 29079
Two-hybrid Homo sapiens
35 NINL  
Two-hybrid Homo sapiens
36 GTF2I 2969
Two-hybrid Homo sapiens
37 RUNX1  
Two-hybrid Homo sapiens
38 AMOTL2 51421
Two-hybrid Homo sapiens
39 KIAA1217 56243
Two-hybrid Homo sapiens
40 SMARCD1 6602
Two-hybrid Homo sapiens
41 CCDC33 80125
Two-hybrid Homo sapiens
42 ATF4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
43 HDX  
Two-hybrid Homo sapiens
44 SMC1A 8243
Affinity Capture-MS Homo sapiens
45 PRPF18  
Two-hybrid Homo sapiens
46 SCOC 60592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PAK7  
Two-hybrid Homo sapiens
48 LCA5  
Two-hybrid Homo sapiens
49 UTP14C  
Two-hybrid Homo sapiens
50 ELOVL5 60481
Proximity Label-MS Homo sapiens
51 BIRC2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 Myh9 17886
Affinity Capture-MS Mus musculus
53 Pank4  
Affinity Capture-MS Mus musculus
54 JPH4 84502
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 ZC4H2 55906
Two-hybrid Homo sapiens
56 GLI1  
Two-hybrid Homo sapiens
57 LZTS2 84445
Two-hybrid Homo sapiens
58 PRPF19 27339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TMEM132A 54972
Affinity Capture-MS Homo sapiens
60 Mis12  
Affinity Capture-MS Mus musculus
61 CCDC85B  
Two-hybrid Homo sapiens
62 GOLGA1  
Proximity Label-MS Homo sapiens
63 C1orf94  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 USHBP1  
Two-hybrid Homo sapiens
65 FBF1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
66 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
67 TMEM170A  
Affinity Capture-MS Homo sapiens
68 RALBP1 10928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 MTHFD2 10797
Co-fractionation Homo sapiens
70 LLGL2 3993
Affinity Capture-MS Homo sapiens
71 TP53BP2  
Two-hybrid Homo sapiens
72 SPOP  
Two-hybrid Homo sapiens
73 ITSN1 6453
Two-hybrid Homo sapiens
74 KIAA0753  
Two-hybrid Homo sapiens
75 FOSL1  
Two-hybrid Homo sapiens
76 IKBKG 8517
Two-hybrid Homo sapiens
77 ZNF276 92822
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 DNAJA3 9093
Two-hybrid Homo sapiens
79 Ckap5 75786
Affinity Capture-MS Mus musculus
80 Rassf1  
Affinity Capture-MS Mus musculus
81 ZFP90  
Two-hybrid Homo sapiens
82 ABI2 10152
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
83 NAB2 4665
Two-hybrid Homo sapiens
84 RAB7A 7879
Proximity Label-MS Homo sapiens
85 FAM83A  
Two-hybrid Homo sapiens
86 ICA1L  
Two-hybrid Homo sapiens
87 TRIM29 23650
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
88 CAV1 857
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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