Gene description for ZC4H2
Gene name zinc finger, C4H2 domain containing
Gene symbol ZC4H2
Other names/aliases HCA127
KIAA1166
WRWF
WWS
Species Homo sapiens
 Database cross references - ZC4H2
ExoCarta ExoCarta_55906
Vesiclepedia VP_55906
Entrez Gene 55906
HGNC 24931
MIM 300897
UniProt Q9NQZ6  
 ZC4H2 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ZC4H2
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    noradrenergic neuron development GO:0003358 IEA
    protein monoubiquitination GO:0006513 IGI
    nervous system development GO:0007399 IDA
    neuromuscular junction development GO:0007528 ISS
    spinal cord motor neuron differentiation GO:0021522 ISS
    positive regulation of neuron differentiation GO:0045666 IBA
    positive regulation of neuron differentiation GO:0045666 IMP
    positive regulation of DNA-binding transcription factor activity GO:0051091 IGI
    regulation of transcription regulatory region DNA binding GO:2000677 IGI
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    protein-containing complex GO:0032991 IDA
    neuronal cell body GO:0043025 IEA
    postsynaptic membrane GO:0045211 IDA
 Experiment description of studies that identified ZC4H2 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ZC4H2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CMIP 80790
Two-hybrid Homo sapiens
2 ZNF669  
Two-hybrid Homo sapiens
3 SLC25A31 83447
Affinity Capture-MS Homo sapiens
4 KRT37 8688
Affinity Capture-MS Homo sapiens
5 RNF220  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 COLEC12 81035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RNF151  
Two-hybrid Homo sapiens
8 DIDO1  
Affinity Capture-MS Homo sapiens
9 SYCE1  
Affinity Capture-MS Homo sapiens
10 HOXB5  
Two-hybrid Homo sapiens
11 RLIM 51132
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 TMEM214 54867
Affinity Capture-MS Homo sapiens
13 VAMP3 9341
Affinity Capture-MS Homo sapiens
14 PARS2 25973
Affinity Capture-MS Homo sapiens
15 FAM161B  
Two-hybrid Homo sapiens
16 PRPH 5630
Two-hybrid Homo sapiens
17 ZNF250  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 HOOK3 84376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ZNF490  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 ATP4B  
Two-hybrid Homo sapiens
21 ZNF223  
Two-hybrid Homo sapiens
22 PMF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ANGPT4  
Affinity Capture-MS Homo sapiens
24 GEM  
Two-hybrid Homo sapiens
25 KRT38 8687
Affinity Capture-MS Homo sapiens
26 ZNF408  
Two-hybrid Homo sapiens
27 ZNF524  
Two-hybrid Homo sapiens
28 KRT75 9119
Affinity Capture-MS Homo sapiens
29 DGCR6  
Two-hybrid Homo sapiens
30 KXD1 79036
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
31 AGGF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SORBS3 10174
Two-hybrid Homo sapiens
33 TCEB2 6923
Affinity Capture-MS Homo sapiens
34 GCC1 79571
Two-hybrid Homo sapiens
35 SREBF2 6721
Positive Genetic Homo sapiens
36 HMG20A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PLEKHN1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZC4H2 is involved
No pathways found





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