Gene description for SLC25A31
Gene name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
Gene symbol SLC25A31
Other names/aliases AAC4
ANT4
SFEC35kDa
Species Homo sapiens
 Database cross references - SLC25A31
ExoCarta ExoCarta_83447
Vesiclepedia VP_83447
Entrez Gene 83447
HGNC 25319
MIM 610796
UniProt Q9H0C2  
 SLC25A31 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for SLC25A31
Molecular Function
    ATP:ADP antiporter activity GO:0005471 IEA
    protein binding GO:0005515 IPI
Biological Process
    male meiosis I GO:0007141 ISS
    spermatogenesis GO:0007283 ISS
    cell differentiation GO:0030154 IEA
    regulation of mitochondrial membrane permeability GO:0046902 ISS
    mitochondrial ADP transmembrane transport GO:0140021 IEA
    negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901029 IBA
    mitochondrial ATP transmembrane transport GO:1990544 IEA
Subcellular Localization
    nucleus GO:0005634 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial permeability transition pore complex GO:0005757 ISS
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IDA
    motile cilium GO:0031514 IEA
 Experiment description of studies that identified SLC25A31 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC25A31
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZC4H2 55906
Affinity Capture-MS Homo sapiens
2 TFCP2 7024
Affinity Capture-MS Homo sapiens
3 PPP4C 5531
Affinity Capture-MS Homo sapiens
4 CHN1  
Affinity Capture-MS Homo sapiens
5 RPS11 6205
Cross-Linking-MS (XL-MS) Homo sapiens
6 SLC25A6 293
Cross-Linking-MS (XL-MS) Homo sapiens
7 C1orf43 25912
Affinity Capture-MS Homo sapiens
8 TGFBR2 7048
Affinity Capture-MS Homo sapiens
9 GGT1 2678
Affinity Capture-MS Homo sapiens
10 RPL6 6128
Cross-Linking-MS (XL-MS) Homo sapiens
11 DNAJB2 3300
Affinity Capture-MS Homo sapiens
12 TBC1D17 79735
Affinity Capture-MS Homo sapiens
13 LRRCC1  
Affinity Capture-MS Homo sapiens
14 ZDHHC17 23390
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
15 SEC16B  
Affinity Capture-MS Homo sapiens
16 CENPH  
Affinity Capture-MS Homo sapiens
17 KRT39  
Affinity Capture-MS Homo sapiens
18 PTBP3 9991
Affinity Capture-MS Homo sapiens
19 CXorf21  
Affinity Capture-MS Homo sapiens
20 HNRNPK 3190
Cross-Linking-MS (XL-MS) Homo sapiens
21 ZC3H10  
Affinity Capture-MS Homo sapiens
22 FBXL3  
Affinity Capture-MS Homo sapiens
23 HLX  
Affinity Capture-MS Homo sapiens
24 CHCHD4  
Affinity Capture-MS Homo sapiens
25 GAPDH 2597
Cross-Linking-MS (XL-MS) Homo sapiens
26 SLC25A4 291
Cross-Linking-MS (XL-MS) Homo sapiens
27 INF2 64423
Affinity Capture-MS Homo sapiens
28 FGF12  
Affinity Capture-MS Homo sapiens
29 WWC1  
Affinity Capture-MS Homo sapiens
30 PINK1  
Affinity Capture-MS Homo sapiens
31 LPAR2 9170
Affinity Capture-MS Homo sapiens
32 C4orf3  
Affinity Capture-MS Homo sapiens
33 MEOX2  
Two-hybrid Homo sapiens
34 DNAJC3 5611
Cross-Linking-MS (XL-MS) Homo sapiens
35 PSMB5 5693
Affinity Capture-MS Homo sapiens
36 CCBE1 147372
Affinity Capture-MS Homo sapiens
37 SLC31A1 1317
Affinity Capture-MS Homo sapiens
38 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
39 UPK1A 11045
Affinity Capture-MS Homo sapiens
40 RABIF  
Affinity Capture-MS Homo sapiens
41 KRTAP10-8  
Two-hybrid Homo sapiens
42 YAP1 10413
Affinity Capture-MS Homo sapiens
43 SCN3B  
Affinity Capture-MS Homo sapiens
44 TXNDC2  
Affinity Capture-MS Homo sapiens
45 FRMPD2  
Affinity Capture-MS Homo sapiens
46 SLC25A5 292
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which SLC25A31 is involved
No pathways found





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