Gene description for PTBP3
Gene name polypyrimidine tract binding protein 3
Gene symbol PTBP3
Other names/aliases ROD1
Species Homo sapiens
 Database cross references - PTBP3
ExoCarta ExoCarta_9991
Entrez Gene 9991
HGNC 10253
MIM 607527
UniProt O95758  
 PTBP3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for PTBP3
Molecular Function
    nucleotide binding GO:0000166 IEA
    RNA binding GO:0003723 TAS
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    mRNA processing GO:0006397 IEA
    negative regulation of mRNA splicing, via spliceosome GO:0048025 IEA
    erythrocyte maturation GO:0043249 IEA
    RNA splicing GO:0008380 IEA
    negative regulation of RNA splicing GO:0033119 IDA
    regulation of cell differentiation GO:0045595 IEA
    anatomical structure morphogenesis GO:0009653 TAS
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified PTBP3 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTBP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PTBP3 is involved
No pathways found





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