Gene description for TXN2
Gene name thioredoxin 2
Gene symbol TXN2
Other names/aliases MT-TRX
MTRX
TRX2
Species Homo sapiens
 Database cross references - TXN2
ExoCarta ExoCarta_25828
Vesiclepedia VP_25828
Entrez Gene 25828
HGNC 17772
MIM 609063
UniProt Q99757  
 TXN2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TXN2
Molecular Function
    protein binding GO:0005515 IPI
    peptide-methionine (S)-S-oxide reductase activity GO:0008113 IEA
    protein-disulfide reductase activity GO:0015035 IEA
    peptide-methionine (R)-S-oxide reductase activity GO:0033743 IEA
    protein-containing complex binding GO:0044877 IEA
Biological Process
    response to hypoxia GO:0001666 IEA
    response to oxidative stress GO:0006979 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    response to hormone GO:0009725 IEA
    response to glucose GO:0009749 IEA
    response to organic cyclic compound GO:0014070 IEA
    cellular response to nutrient levels GO:0031669 IEA
    cell redox homeostasis GO:0045454 IBA
    response to axon injury GO:0048678 IEA
Subcellular Localization
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
 Experiment description of studies that identified TXN2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TXN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYRM2  
Co-fractionation Homo sapiens
2 AP2B1 163
Two-hybrid Homo sapiens
3 GUK1 2987
Co-fractionation Homo sapiens
4 TRIAP1  
Co-fractionation Homo sapiens
5 TMEM205 374882
Co-fractionation Homo sapiens
6 HSPA1L 3305
Co-fractionation Homo sapiens
7 C2orf50  
Affinity Capture-MS Homo sapiens
8 TIGAR 57103
Co-fractionation Homo sapiens
9 IL36RN  
Affinity Capture-MS Homo sapiens
10 ANXA6 309
Co-fractionation Homo sapiens
11 ILF2 3608
Co-fractionation Homo sapiens
12 HADH 3033
Co-fractionation Homo sapiens
13 MAP3K5 4217
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
14 MRFAP1L1  
Two-hybrid Homo sapiens
15 C2orf73  
Affinity Capture-MS Homo sapiens
16 MX2 4600
Co-fractionation Homo sapiens
17 KRT40  
Two-hybrid Homo sapiens
18 PTRHD1 391356
Co-fractionation Homo sapiens
19 MRPL23 6150
Co-fractionation Homo sapiens
20 RECK 8434
Affinity Capture-MS Homo sapiens
21 WDR12 55759
Co-fractionation Homo sapiens
22 FMNL2 114793
Affinity Capture-MS Homo sapiens
23 DCTD 1635
Two-hybrid Homo sapiens
24 MYO1B 4430
Affinity Capture-MS Homo sapiens
25 FAM98B 283742
Co-fractionation Homo sapiens
26 UCHL5 51377
Reconstituted Complex Homo sapiens
27 ZBTB14  
Two-hybrid Homo sapiens
28 COX17  
Co-fractionation Homo sapiens
29 PPCDC  
Two-hybrid Homo sapiens
30 SOD1 6647
Co-fractionation Homo sapiens
31 PRNP 5621
Affinity Capture-MS Homo sapiens
32 PSME3 10197
Two-hybrid Homo sapiens
33 GOLIM4 27333
Co-fractionation Homo sapiens
34 RABGEF1 27342
Two-hybrid Homo sapiens
35 MTUS2 23281
Two-hybrid Homo sapiens
36 PRDX5 25824
Co-fractionation Homo sapiens
37 RPL9 6133
Co-fractionation Homo sapiens
38 AGTRAP 57085
Two-hybrid Homo sapiens
39 UBR5 51366
Affinity Capture-Western Homo sapiens
40 VCP 7415
Co-fractionation Homo sapiens
41 TRIM21 6737
Two-hybrid Homo sapiens
42 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
43 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
44 FAM9B  
Two-hybrid Homo sapiens
45 LYPLA1 10434
Co-fractionation Homo sapiens
46 ANLN 54443
Affinity Capture-MS Homo sapiens
47 CCDC114  
Two-hybrid Homo sapiens
48 AK2 204
Co-fractionation Homo sapiens
49 BAX 581
Co-fractionation Homo sapiens
50 GIMAP8 155038
Co-fractionation Homo sapiens
51 MAGEA11  
Two-hybrid Homo sapiens
52 ANXA1 301
Co-fractionation Homo sapiens
53 ALDOB 229
Two-hybrid Homo sapiens
54 NR3C1 2908
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
55 FAHD1 81889
Co-fractionation Homo sapiens
56 AK3 50808
Co-fractionation Homo sapiens
57 GPRASP2  
Two-hybrid Homo sapiens
58 SPTBN1 6711
Co-fractionation Homo sapiens
59 THAP1  
Two-hybrid Homo sapiens
60 MAPRE3  
Two-hybrid Homo sapiens
61 RABAC1 10567
Two-hybrid Homo sapiens
62 SSNA1 8636
Two-hybrid Homo sapiens
63 MSRB3 253827
Co-fractionation Homo sapiens
64 RBM45  
Two-hybrid Homo sapiens
65 RPIA 22934
Two-hybrid Homo sapiens
66 TBCA 6902
Co-fractionation Homo sapiens
67 HINT1 3094
Co-fractionation Homo sapiens
68 TPM4 7171
Co-fractionation Homo sapiens
69 REEP6  
Two-hybrid Homo sapiens
70 RPS16 6217
Co-fractionation Homo sapiens
71 STUB1 10273
Two-hybrid Homo sapiens
72 COA4  
Co-fractionation Homo sapiens
73 KRT18 3875
Two-hybrid Homo sapiens
74 RELA 5970
Affinity Capture-Western Homo sapiens
75 TRIP6 7205
Two-hybrid Homo sapiens
76 SUMF2 25870
Co-fractionation Homo sapiens
77 TIFA  
Two-hybrid Homo sapiens
78 ILF3 3609
Co-fractionation Homo sapiens
79 SCYL3 57147
Two-hybrid Homo sapiens
80 TOMM22 56993
Co-fractionation Homo sapiens
81 VPS52 6293
Two-hybrid Homo sapiens
82 COX5A 9377
Co-fractionation Homo sapiens
83 GABARAPL2 11345
Co-fractionation Homo sapiens
84 MAPRE2 10982
Two-hybrid Homo sapiens
85 PTBP3 9991
Co-fractionation Homo sapiens
86 MLH1 4292
Two-hybrid Homo sapiens
87 CAPZB 832
Affinity Capture-MS Homo sapiens
88 NUDT19 390916
Co-fractionation Homo sapiens
89 TXN 7295
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
90 MOV10 4343
Affinity Capture-RNA Homo sapiens
91 SNRNP70 6625
Co-fractionation Homo sapiens
92 ACOT1 641371
Co-fractionation Homo sapiens
93 RPL8 6132
Co-fractionation Homo sapiens
94 SHARPIN  
Two-hybrid Homo sapiens
95 TXNIP 10628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
96 VIM 7431
Two-hybrid Homo sapiens
97 AK1 203
Co-fractionation Homo sapiens
View the network image/svg+xml



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