Gene description for RECK
Gene name reversion-inducing-cysteine-rich protein with kazal motifs
Gene symbol RECK
Other names/aliases ST15
Species Homo sapiens
 Database cross references - RECK
ExoCarta ExoCarta_8434
Entrez Gene 8434
HGNC 11345
MIM 605227
UniProt O95980  
 RECK identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RECK
Molecular Function
    protein binding GO:0005515 IPI
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    endopeptidase inhibitor activity GO:0004866 IDA
    metalloendopeptidase inhibitor activity GO:0008191 TAS
Biological Process
    extracellular matrix organization GO:0030198 IEA
    negative regulation of endopeptidase activity GO:0010951 IEA
    embryo implantation GO:0007566 IEA
    blood vessel maturation GO:0001955 IEA
Subcellular Localization
    membrane GO:0016020 TAS
    anchored component of membrane GO:0031225 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified RECK in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RECK
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RECK is involved
No pathways found





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