Gene description for MX2
Gene name MX dynamin-like GTPase 2
Gene symbol MX2
Other names/aliases MXB
Species Homo sapiens
 Database cross references - MX2
ExoCarta ExoCarta_4600
Vesiclepedia VP_4600
Entrez Gene 4600
HGNC 7533
MIM 147890
UniProt P20592  
 MX2 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MX2
Molecular Function
    GTPase activity GO:0003924 IBA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IMP
    microtubule binding GO:0008017 IBA
Biological Process
    defense response GO:0006952 TAS
    response to virus GO:0009615 IDA
    protein transport GO:0015031 IEA
    synaptic vesicle budding from presynaptic endocytic zone membrane GO:0016185 IBA
    receptor internalization GO:0031623 IBA
    response to interferon-alpha GO:0035455 IDA
    innate immune response GO:0045087 IEA
    regulation of nucleocytoplasmic transport GO:0046822 IMP
    mRNA transport GO:0051028 IEA
    defense response to virus GO:0051607 IBA
    defense response to virus GO:0051607 IMP
    regulation of cell cycle GO:0051726 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nuclear pore GO:0005643 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    microtubule GO:0005874 IBA
    plasma membrane GO:0005886 IBA
    synapse GO:0045202 IBA
 Experiment description of studies that identified MX2 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TXN2 25828
Co-fractionation Homo sapiens
2 NUP214 8021
Affinity Capture-MS Homo sapiens
3 PIAS2  
Two-hybrid Homo sapiens
4 TXN 7295
Co-fractionation Homo sapiens
5 PRDX5 25824
Co-fractionation Homo sapiens
6 MX2 4600
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 FXN  
Co-fractionation Homo sapiens
8 RHOA 387
Co-fractionation Homo sapiens
9 AK2 204
Co-fractionation Homo sapiens
10 ATRIP  
Two-hybrid Homo sapiens
11 TXNDC12 51060
Co-fractionation Homo sapiens
12 XPO1 7514
Affinity Capture-MS Homo sapiens
13 EHMT2 10919
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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