Gene description for MX2
Gene name MX dynamin-like GTPase 2
Gene symbol MX2
Other names/aliases MXB
Species Homo sapiens
 Database cross references - MX2
ExoCarta ExoCarta_4600
Entrez Gene 4600
HGNC 7533
MIM 147890
UniProt P20592  
 MX2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MX2
Molecular Function
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IMP
    GTPase activity GO:0003924 IEA
Biological Process
    cytokine-mediated signaling pathway GO:0019221 TAS
    defense response GO:0006952 TAS
    response to interferon-alpha GO:0035455 IDA
    protein transport GO:0015031 IEA
    response to virus GO:0009615 IDA
    metabolic process GO:0008152 TAS
    regulation of cell cycle GO:0051726 IMP
    defense response to virus GO:0051607 IMP
    type I interferon signaling pathway GO:0060337 TAS
    regulation of nucleocytoplasmic transport GO:0046822 IMP
    mRNA transport GO:0051028 IEA
Subcellular Localization
    nuclear pore GO:0005643 IDA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 TAS
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified MX2 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MX2 4600
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MX2 is involved
PathwayEvidenceSource
Interferon alpha/beta signaling TAS Reactome
ISG15 antiviral mechanism TAS Reactome





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